dbPTM

TTKA_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TTKA_DROME
UniProt AC	P42282
Protein Name	Protein tramtrack, alpha isoform
Gene Name	ttk
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	813
Subcellular Localization	Nucleus .
Protein Description	Binds to a number of sites in the transcriptional regulatory region of ftz. Isoform alpha is required to repress genes that promote the R7 cell fate. Probable repressor of the transcription of the segmentation genes ftz, eve, h, odd, run, and en. May bind to the region 5'-AGGG[CT]GG-3'. Degradation of ttk is directed by binding of sinah or sina, via the adapter molecule phyl which binds to the BTB domain of ttk..
Protein Sequence	MKMASQRFCLRWNNHQSNLLSVFDQLLHAETFTDVTLAVEGQHLKAHKMVLSACSPYFNTLFVSHPEKHPIVILKDVPYSDMKSLLDFMYRGEVSVDQERLTAFLRVAESLRIKGLTEVNDDKPSPAAAAAGAGATGSESTATTPQLQRIQPYLVPQRNRSQAGGLLASAANAGNTPTLPVQPSLLSSALMPKRKRGRPRKLSGSSNGTGNDYDDFDRENMMNDSSDLGNGKMCNESYSGNDDGSDDNQPNAGHTDDLNESRDSLPSKRSKNSKDHRVVSHHEDNSTSVTPTKATPELSQRLFGSSSTTISATAPGGSSTGPSETISLLEISDERESAPVHLPTILGLKIRAINTTTPAQQGSPQTPTKSKPKIRQATGSNNSNSLLKQQLRGGAKDPEVPPATRITGAVTPNAALNAEEQSKEMPKKNQDEVNACIGLHSLANAAEQQAAQVASTGNLHHQLLLHMAANNSMLNTTDYYQQQQQESPSSAGQFMDDDLELLSLNDQQDKSDEPDHEMVTLADENAGLPGYQGNEAEATPAQEDSPAAETATAPPPAPRSGKKGAKRPIQRRRVRRKAQSTLDDQAEHLTEMSVRGLDLFRYASVVEGVYRCTECAKENMQKTFKNKYSFQRHAFLYHEGKHRKVFPCPVCSKEFSRPDKMKNHLKMTHENFTPPKDIGAFSPLKYLISAAAAGDMHATIYQQQQDHYHRQLAEQLEQQNASFDSRDSSLILPDVKMEHAEDQDAEQEAELSDGGYDASNPAAAAAAMLSLQQDVIIKDEIQISPSPSPTPPASCAVAEGKSLALASTAQTAT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
203	Phosphorylation	RGRPRKLSGSSNGTG CCCCCCCCCCCCCCC	39.40	22817900
205	Phosphorylation	RPRKLSGSSNGTGND CCCCCCCCCCCCCCC	19.77	22817900
206	Phosphorylation	PRKLSGSSNGTGNDY CCCCCCCCCCCCCCC	42.69	22817900
209	Phosphorylation	LSGSSNGTGNDYDDF CCCCCCCCCCCCHHC	36.74	29892262
682	Phosphorylation	PKDIGAFSPLKYLIS CHHCCCCCHHHHHHH	28.87	18327897
722	Phosphorylation	QLEQQNASFDSRDSS HHHHHCCCCCCCCCC	36.82	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	sina	P21461	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TTKA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TTKA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LOLAL_DROME	lolal	physical	14605208
PP4C_DROME	Pp4-19C	physical	14605208
STAT_DROME	Stat92E	physical	14605208
DEI_DROME	tx	physical	14605208
ARRA_DROME	Arr1	physical	14605208
JMJD4_DROME	CG7200	physical	14605208
KU70_DROME	Irbp	physical	22036573
RFC1_DROME	Gnf1	physical	22036573
SINA_DROME	sina	physical	12215542
PHYL_DROME	phyl	physical	12215542
LOZEN_DROME	lz	genetic	20003234
AFF4_DROME	lilli	genetic	11171404
UBPE_DROME	Ubp64E	genetic	18160715
CHDM_DROME	Mi-2	genetic	11743021
CTBP_DROME	CtBP	genetic	10978285
MPIP_DROME	stg	genetic	12447387
GIANT_DROME	gt	physical	23935523
HANG_DROME	hang	physical	25242320
PHYL_DROME	phyl	physical	9267026
OTP_DROME	otp	physical	25242320
DICH_DROME	D	physical	23935523
TTKB_DROME	ttk	physical	23847101
TTKA_DROME	ttk	physical	23847101
TTKB_DROME	ttk	physical	12204250
TTKA_DROME	ttk	physical	12204250
TTKB_DROME	ttk	physical	12384587
TTKA_DROME	ttk	physical	12384587

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TTKA_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203; SER-205; SER-206;THR-209 AND SER-682, AND MASS SPECTROMETRY.	18327897 [Abstract]