UBPE_DROME - dbPTM
UBPE_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UBPE_DROME
UniProt AC Q24574
Protein Name Ubiquitin carboxyl-terminal hydrolase 47 {ECO:0000250|UniProtKB:Q96K76}
Gene Name Usp47 {ECO:0000303|PubMed:27552662, ECO:0000312|FlyBase:FBgn0016756}
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1556
Subcellular Localization Nucleus .
Protein Description Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways. [PubMed: 10949024]
Protein Sequence MTDKESEQCTVSVFDQTPGSEQKKINVVVRSHFTVKRVIDLIGTQFSYEKFELLLQPHDNKDLVNLNALESQLMYEVAGFEPQLKNHLILLPSGSWDGDVTKRFELPIKRVVVKKVMKSDGEKAKSPATGEKKKRVVGEKTKKKPASGSSSPSKAKTTSEDSLAKTSISSESSPEKTSKIKTTAAKISKPGSEKAPRASPEECPELSTEINSKNTSSESPVAKKTAKVTSKPTLELLSPIKPSSPIKELDCEPVDTLSKQQLSEQLQLYPQGRNLISPVDDAPSDLFISDAEQLSDDDLALGASASPTMLGPGYDYGAPTGDSDVEGVTGVTDPSTIGTDDGTYPALSNFYRRKYGGDELRAWQRVNTTGADFVSSATTETEAEARQASLGPRGYVGLVNQAMTCYLNSLLQALFMTPEFRNALYRWEFDNDNEAKNIPYQLQKLFLNLQTSPKAAVETTDLTRSFGWDSTEAWQQHDIQELCRVMFDALEHKFKNTKQANLISNLYEGKMNDYVKCLECNTEKTREDTFLDIPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYLCEKCKKKCDAHKGLHFKSFPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQNSQLNGTVDDCSTADSGSAMEDDNLSSGVVTTASSSQHENDLNDEDEGIDMSSSTSKSAKQGSGPYLYELFAIMIHSGSASGGHYYAYIKDFDNNEWFCFNDQNVTSITQEDIQRSFGGPNGSYYSSAYTSSTNAYMLMYRQVDAKRNELVAKVADFPEHIKTLLPKLHSEEETRVSRLGRHITVTDLALPDLYKPRVYFYNPSLKKMKITRVYVSQSFNINLVLMSAYEMLNVEQFAPLSRCRLVAYNSSMDTIIQSLESCTDPALTELRAAQNYSLDFLLEYRAEDQEFEVYPPNGITWYVFKVDLSTMAMDGPFLVYSAAREREASDVLRRSIALRLHISEQQFLLATVRATVPKAFVSYDPHPTPEALQHLQNMANTQFKSITYFYLNVPNTDAATLEMLGVPTVESVECASGGDVVDAAMMNGVAPGHMSSSNDYDWRRYKRDLVEPMSQPSPSHGHESNSEDSSLSDGDRTLVETDNMAHRGGGDSQVSSTSHSPQLSSPEDEAASHDAMMRVHAYCNGNGSYAAADVVDPLLLPTSTNHFFYATKVECVDVVGTGSSSGHQSDEEAQLRKPTRAYKLLVGTHMRMGAFKKHIEQLIQVPAAHFKLQRKHDNNLSNNQNNSLVHLIEGETLTVELGKTLEPDEFKAKIHFLRLADIDNETSKLPCVCEWVYNANTTAEQAKKELVAKLHRIDAKYATLSVQNCRIWLKGGRIPIKILSDDETLYCDMRSSIAAEFIVQECEEEVDPQPKDDSLTLFVRRWCPAKLEFGKFQEITLDQDSEIRLSLSQISDIPIDKLSYMKLNSNFPCTSISALSVNESSSWYSVPTTLDKYPLNSTQTGNIYLYKDRTVPARELTLEERRLMNAREKARLDRVGCVSTTRYAQRRERALKIYLDSPEKSSNVTASAPMDVHVNN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
126PhosphorylationSDGEKAKSPATGEKK
CCCCCCCCCCCCCCH		25.3227626673
147PhosphorylationKTKKKPASGSSSPSK
CCCCCCCCCCCCCCC		47.9719429919
149PhosphorylationKKKPASGSSSPSKAK
CCCCCCCCCCCCCCC		25.7519429919
150PhosphorylationKKPASGSSSPSKAKT
CCCCCCCCCCCCCCC		50.2019429919
151PhosphorylationKPASGSSSPSKAKTT
CCCCCCCCCCCCCCC		34.5819429919
153PhosphorylationASGSSSPSKAKTTSE
CCCCCCCCCCCCCCH		47.3919429919
169PhosphorylationSLAKTSISSESSPEK
HHHHHCCCCCCCHHH		28.0227794539
172PhosphorylationKTSISSESSPEKTSK
HHCCCCCCCHHHHCC		53.8119429919
173PhosphorylationTSISSESSPEKTSKI
HCCCCCCCHHHHCCC		32.7819429919
199PhosphorylationSEKAPRASPEECPEL
CCCCCCCCHHHCCCC		33.8428490779
217PhosphorylationINSKNTSSESPVAKK
CCCCCCCCCCCCCHH		39.8029892262
219PhosphorylationSKNTSSESPVAKKTA
CCCCCCCCCCCHHHC		26.9925749252
229PhosphorylationAKKTAKVTSKPTLEL
CHHHCCCCCCCCHHH		30.2628490779
230PhosphorylationKKTAKVTSKPTLELL
HHHCCCCCCCCHHHC		39.3628490779
233PhosphorylationAKVTSKPTLELLSPI
CCCCCCCCHHHCCCC		36.2828490779
238PhosphorylationKPTLELLSPIKPSSP
CCCHHHCCCCCCCCC		36.8819429919
243PhosphorylationLLSPIKPSSPIKELD
HCCCCCCCCCCCCCC		43.6819429919
244PhosphorylationLSPIKPSSPIKELDC
CCCCCCCCCCCCCCC		38.8919429919
256PhosphorylationLDCEPVDTLSKQQLS
CCCCCCCCCCHHHHH		32.9221082442
389PhosphorylationEAEARQASLGPRGYV
HHHHHHHCCCCCCHH		26.0627626673
820PhosphorylationSRLGRHITVTDLALP
HHHCCCEEEECCCCC		15.9521082442
1093PhosphorylationVEPMSQPSPSHGHES
CCCCCCCCCCCCCCC		31.2530478224
1131PhosphorylationGGGDSQVSSTSHSPQ
CCCCCCCCCCCCCCC		21.9122817900
1132PhosphorylationGGDSQVSSTSHSPQL
CCCCCCCCCCCCCCC		34.7622817900
1134PhosphorylationDSQVSSTSHSPQLSS
CCCCCCCCCCCCCCC		24.7422668510
1136PhosphorylationQVSSTSHSPQLSSPE
CCCCCCCCCCCCCCC		17.7022817900
1140PhosphorylationTSHSPQLSSPEDEAA
CCCCCCCCCCCHHHH		38.3022817900
1141PhosphorylationSHSPQLSSPEDEAAS
CCCCCCCCCCHHHHC		40.6822817900
1197PhosphorylationECVDVVGTGSSSGHQ
EEEEEECCCCCCCCC		23.4529892262
1199PhosphorylationVDVVGTGSSSGHQSD
EEEECCCCCCCCCCH		22.5922817900
1200PhosphorylationDVVGTGSSSGHQSDE
EEECCCCCCCCCCHH		41.5029892262
1201PhosphorylationVVGTGSSSGHQSDEE
EECCCCCCCCCCHHH		41.8329892262
1205PhosphorylationGSSSGHQSDEEAQLR
CCCCCCCCHHHHHHC		41.1222817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UBPE_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UBPE_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UBPE_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TTKB_DROMEttkgenetic
18160715
TTKA_DROMEttkgenetic
18160715
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UBPE_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172; SER-173; SER-238;SER-1131; SER-1132; SER-1140; SER-1141; SER-1199; SER-1201 ANDSER-1205, AND MASS SPECTROMETRY.

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