ASH1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASH1_DROME
• UniProt AC: Q9VW15
• Protein Name: Histone-lysine N-methyltransferase ash1
• Gene Name: ash1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 2226
• Subcellular Localization: Nucleus. Chromosome . Localizes at the promoter of active genes.
• Protein Description: Trithorax group (TrxG) protein that has histone methyltransferase activity. [PubMed: 13679578]
• Protein Sequence: MSCSQNETAAAKVLETQRAQESGSENEETDSITDQSSQSKSIKSATQFSVQRSDTDGLRMRISAIRPTLGVVATKKPPKSRKMSTQDTESGCSEAKNRAVSKKVKVKRKKLASSSGISKSDKVSKSKKSQISAFSSDSEDDLPLKVHQQRAPRVLLSAIIQAAQSASKPTLDIGISSSDNELPNLVQAAIKRVESDTEDTTVEGSFRKAAKDKNLPQYQSTLLQDFMEKTQMLGQTVNAKLAEEKVAKAKEETLVQTAVPRKRRGRPKKVVPTVPAPGNSGPAINESADSGVISTTSTTQSTTPSPKMQNENAVPTGSLPIASSSKPKIDMAYLDKRMYATERVLYPPPRSKRRQNNKKTACSSSNKEELQLDPLWREIDVNKKFRLRSMSVGAASGTGASTTICSKVLAAKSGYVSDYGSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRASMLLKSSADDTVEDQDILQLAGLSLGQSSEESNEYISKPSLKSLPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPDNFISKMMNQRKETPAPSKSSCKIKSRRSSAASMCSSYVSGVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLLADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLSASASGTPNGSGSSNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANGKLNAEAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSALDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQAGEARETFVARTNQKAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAEAAPQPPPKSEPEIRPAKKRGRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEHDPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNKKPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDHPTCNCKNQGEKSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGGKSQRVKPLPAVEAKPSGEGLSGRNGRQRKQKAKKHAQRQAGKDISSAVAVAKLQPLSEKEKKLVRQFNTFLVRNFEKIRRCKAKRASDAAATASSPALGTTNGDIPGRRPSTPSSPSLAAQISALCSPRNIKTRGLTQAVHDPELEKMAKMAVVLRDICSAMETLKMSDLLTTVSSKKKKPIKTTLSGKLGSTAATSKVEFRSIQAQVEQGHYKTPQEFDDHMQQLFVEAKQQHGDDEGKEKALQSLKDSYEQQKIASYVQLVEILGDSESLQSFKPKEVLSSEEEPGKIAVKKSPGAKERDSPIVPLKVTPPPLLPIEASPDEDVIRCICGLYKDEGLMIQCSKCMVWQHTECTKADIDADNYQCERCEPREVDREIPLEEFTEEGHRYYLSLMRGDLQVRQGDAVYVLRDIPIKDESGKVLPTKKHTYETIGAIDYQECDIFRVEHLWKNELGKRFIFGHHFLRPHETFHEPSRRFYPNEVVRVSLYEVVPIELVIGRCWVLDRTTFCKGRPMECNDEDHCYICELRVDKTARFFSKAKANHPACTKSYAFRKFPEKIKISKSYAPHDVDPSLLKTRKQKTELDVGAGPTTMHKVSGRQEQHQAKMVGRKPRGISAPADATAVHVVTPVAPNKQMLKKRKSRLENVLITMKLKCLDAQTAQEQPIDLSYLLSGRGARQRKTQQSSSSSTANST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
135	Phosphorylation	KSQISAFSSDSEDDL HHHHHCCCCCCCCCC	32.71	19429919
136	Phosphorylation	SQISAFSSDSEDDLP HHHHCCCCCCCCCCC	38.41	19429919
138	Phosphorylation	ISAFSSDSEDDLPLK HHCCCCCCCCCCCCH	44.89	19429919
200	Phosphorylation	VESDTEDTTVEGSFR HHCCCCCCCCCCHHH	26.89	22817900
201	Phosphorylation	ESDTEDTTVEGSFRK HCCCCCCCCCCHHHH	28.96	22817900
417	Phosphorylation	AAKSGYVSDYGSVRH HHCCCCCCCCCHHCC	19.34	25749252
483	Phosphorylation	MRRKRRASMLLKSSA HHHHHHHHHHHHCCC	14.25	27626673
740	Phosphorylation	KKSQSNDSSSPDDHK CCCCCCCCCCCCCCC	36.65	22817900
741	Phosphorylation	KSQSNDSSSPDDHKL CCCCCCCCCCCCCCC	49.07	22817900
742	Phosphorylation	SQSNDSSSPDDHKLP CCCCCCCCCCCCCCC	35.98	22817900
827	Phosphorylation	SVSGAGSSASNSPLR CCCCCCCCCCCCCCE	34.50	22817900
831	Phosphorylation	AGSSASNSPLRIVVD CCCCCCCCCCEEEEE	23.86	22817900
868	Acetylation	QRRGGAAKQKVSAAK HHCCCHHHHHHHHHH	50.55	-
868	Acetylation	QRRGGAAKQKVSAAK HHCCCHHHHHHHHHH	50.55	21791702
870	Acetylation	RGGAAKQKVSAAKDL CCCHHHHHHHHHHHH	37.13	21791702
870	Acetylation	RGGAAKQKVSAAKDL CCCHHHHHHHHHHHH	37.13	-
977	Phosphorylation	RRKKRKVSVEQQTTA CCCCCCCCHHHHHEE	23.99	22817900
1826	Phosphorylation	GKIAVKKSPGAKERD CCEEEECCCCCCCCC	23.89	27794539
1952	Acetylation	PIKDESGKVLPTKKH CCCCCCCCCCCCCCC	50.29	21791702
1952	Acetylation	PIKDESGKVLPTKKH CCCCCCCCCCCCCCC	50.29	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASH1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASH1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASH1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JHD1_DROME	Kdm2	genetic	18923078
DOM_DROME	dom	genetic	11262242
FSH_DROME	fs(1)h	physical	23442797
TRX_DROME	trx	physical	10454589

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135; SER-136; SER-138;THR-200; THR-201; SER-740; SER-831 AND SER-977, AND MASS SPECTROMETRY.
PubMed: 18327897