DOM_DROME - dbPTM
DOM_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DOM_DROME
UniProt AC Q9NDJ2
Protein Name Helicase domino
Gene Name dom
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 3198
Subcellular Localization Nucleus .
Protein Description Mediates the ATP-dependent exchange of unmodified histone H2AV for its phosphorylated and acetylated form H2AVK5acS138ph, leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in Notch signaling. Represses E2F target genes. Required for somatic stem cell self-renewal but not for germline stem cell self-renewal. Involved in oogenesis..
Protein Sequence MNEGNSAGGGHEGLSPAPPAVPDRVTPHSTEISVAPANSTSTTVRAAGSVGAALPATRHHQHIATQVKGIASSSSKQQKQLASAQLPVPLSPLPQQQQQTAEATAAAAAPAHSNVSVSSSTIEASVLPPQAKRQRLDDNEDRTSAASIVGPAESSNIVSSLLPASVASSSEVGGLSSTALQDLNALKKRILQQKLQILRNLKERHLENVSEYFYLQNGGSMMDYPAWRKKTPTPQFISYSNANRIDQLIHEDKPSTSAAAAAAQNQKYTTQQTDSVESSLVSGIGTGATKGAPLDGNISNSTVKTNTQSQVPSKIGSFTESTPAATESNSSTTVPGTATSGAATSTSATSAEASGNVLAVEAEIKIPAVGATPVAISTKLPAAVVQLTQQGGTPLLPCNTSAGSTALRRPQGQNNASSGSAAASGGGGSLTPTPLYTGNGPAALGGSGGLTPGTPTSGSLLSPALGGGSGTPNSAAQEFSFKAKQEVYVMQRISELQREGLWTERRLPKLQEPSRPKAHWDYLLEEMVWLAADFAQERKWKKNAAKKCAKMVQKYFQDKATAAQRAEKAQELQLKRVASFIAREVKSFWSNVEKLVEYKHQTKIEEKRKQALDQHLSFIVDQTEKFSQQLVEGMNKSVADTPSLNSSRLTSPKRESDDDFRPESGSEDDEETIAKAEEDAADVKEEVTALAKESEMDFDDFLNDLPPGYLENRDKLMKEEQSSAIKTETPDDSDDSEFEAKEASDDDENTISKQEEAEQEIDHKKEIDELEADNDLSVEQLLAKYKSEQPPSPKRRKLAPRDPELDSDDDSTAVDSTEESEDAATEDEEDLSTVKTDTDMEEQDEQEDGLKSLMADADATSGAAGSGSTAGASGNKDDMLNDAAALAESLQPKGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIVVPSSVMLNWEMEFKKWCPGFKILTYYGSQKERKLKRVGWTKPNAFHVCITSYKLVVQDQQSFRRKKWKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKEWFSNPMTGMIEGNMEYNETLITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSRAKTRETLQTGNLLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQINLETLNLLLLHLEQTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVGASPAMRLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPTGALSVLSNSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTTSRTTVTASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKVQELIQMRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLLKSFEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALLHPIISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLDGSTRVEQRQILMERFNGDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQSEQDESSQEKSENKDRIVATTTLSDTPSTVVETEKQSLRAFEHALAAAEDEQDVQATKTAKAEVAADLAEFDENIPIATEDPNAEGGPQVELSKADLEMQNLVKQLSPIERYAMRFVEETGAAWTAEQLRAAEAELEAQKREWEANRLAAMHKEEELLKQETEAEEMLTYSRKDSSNQVWISRNTMEQMPMWCPPTPPQDNDNDIYIDYSLSFMYELEPIAETDLPPVYVRKEHKRSRTDAGYDGSRRPNKMRREDNYVPPRSLFDRPTPQLARLRRELKSQRFRGSFKPNMPIPGLKPQLPTKPLTEPEAMAEWCVFEDMAILHVLVNLQGLPCSLMLLSPGQTPNWDLVSEMVNFCSKTYRSARQCRWRYETHIQPREEGKVVESPKKQKKLKPTLRTEYLKSPLRYLRTTQLYVSDNNASFYKTMRSRFDSIKTAYLKKAPPPKRQFSAPSLMNPKHMEVLQEFGILNYDQPVSPQNIAAMKANKIREKQRGQQMSQPPVGVGVVQQMQQQSQQQQQPAPPPLPQQQQPQQVVQQVQQQQQQQQQQQQQQVVQQQLPTVSNVQQTLPVQQTVELVQQQPTTTTTVAVPAAGGQLQQLQIQHLTSSNVSPGQQTAILLHQPQQQLRTHPGQGGQSNTQQLVKTIVGTSSSLTAGQLQQLAQQSAVASGGQSSVSVVLTTPVQTLPSVVQPQIGSGAQIVSISSQTLPVNSSPQLGSIVQTQSLPQVVSVSTLPTVGTVLTTTANQPQQQHQTTAVTTLNTTMLRGQRIVSTAAGNTLQQRTTAGGQSIVSMPNLGQGASPSQFQTQLRLAAVPTSPATQTTQLVTTKGIPVSALQQGGKTTVIPVTQQSGGAHIQLYRQRSLKVLQTTTQAVPSGSAGATGATANLVQAGGTIIQASNMATHVTSQKVAVSGMPGTSTTVQAGNVVSSVQMHGQARTQFIKQMAAGKQQLQRQVVSADGTTTTTAAGDMLLVKRHNILAAQKAQQASGALFTTTTGQQQQQQQQQGQLPVAGQPQQVTQHQIASLVKASTAAAASGSSVNAGGVTVSATNPTVQAGSVNMTLPQLKPGSQIKVTMPNQMRHLQMQQQLTMPRKISRMTQLVSASGQPTATNIITTTGPQQQQQGVTVSGGGTLPTVASQQQQQQHQQKVGGGNSVQAQLLHIQNTKGLSNSVTMQQIQQVMRSGQQGTLATTNLVLGKTSVGRVIPVSVASQANQRQTIQVVSAASAQALAAGNLRTHVAGPSIASTLKVAAPGSAGGQTTQQTLIAALQHNQRQNASPVRLQTTAGGNLLAVVQQQQQQQHTSIAGPTAGPAEVMTITQTTTTLPTVGSLQQQQQQQQQQGGISQPTTQQVRKLVQKKILIRSEKE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
643PhosphorylationKSVADTPSLNSSRLT
HHHCCCCCCCCCCCC		42.1319429919
656PhosphorylationLTSPKRESDDDFRPE
CCCCCCCCCCCCCCC		50.8219429919
664PhosphorylationDDDFRPESGSEDDEE
CCCCCCCCCCCCHHH		50.7519429919
666PhosphorylationDFRPESGSEDDEETI
CCCCCCCCCCHHHHH		47.3219429919
672PhosphorylationGSEDDEETIAKAEED
CCCCHHHHHHHHHHH		24.9619429919
729PhosphorylationSSAIKTETPDDSDDS
HHCCCCCCCCCCCCC		36.9322817900
733PhosphorylationKTETPDDSDDSEFEA
CCCCCCCCCCCHHCH		51.1819429919
736PhosphorylationTPDDSDDSEFEAKEA
CCCCCCCCHHCHHHC		49.5319429919
744PhosphorylationEFEAKEASDDDENTI
HHCHHHCCCCCCCCC		42.5419429919
792PhosphorylationYKSEQPPSPKRRKLA
HHCCCCCCCCCCCCC		50.1425749252
836PhosphorylationEDLSTVKTDTDMEEQ
HHHHCCCCCCCHHHH		39.5319429919
838PhosphorylationLSTVKTDTDMEEQDE
HHCCCCCCCHHHHHH		42.3419429919
1297PhosphorylationRFHIRVRSAELAQRI
EEEEEECCHHHHHHH		24.2027626673
1323AcetylationAMRLEGSKIMPMRNL
HHCCCCCCCCCHHHC		54.61-
1398AcetylationINAPTPAKVAKTMQD
CCCCCCHHHHHHCCC		43.88-
1407AcetylationAKTMQDGKPFFYLTP
HHHCCCCCEEEEEEC		47.11-
1461AcetylationLIRDPIVKDLATHVK
HHCCHHHHHHHHHHH		47.98-
1473AcetylationHVKSTVQKQSIANGK
HHHHHHHHHHHHCCC		41.50-
1480AcetylationKQSIANGKTEPEEET
HHHHHCCCCCCHHHC		49.90-
2041 (in isoform 2)Phosphorylation-11.3019429919
2042 (in isoform 2)Phosphorylation-7.9819429919
2044 (in isoform 2)Phosphorylation-18.4919429919
2114 (in isoform 2)Phosphorylation-41.8718327897
2185 (in isoform 2)Phosphorylation-30.7827626673
2195 (in isoform 2)Phosphorylation-37.0618327897
2216PhosphorylationEEGKVVESPKKQKKL
CCCCCCCCHHHHCCC		30.3422817900
2365 (in isoform 2)Phosphorylation-2.6118327897
2368 (in isoform 2)Phosphorylation-2.8718327897
2371 (in isoform 2)Phosphorylation-26.4218327897
2646PhosphorylationRLAAVPTSPATQTTQ
HEEECCCCCCCCEEE		13.3821082442
2772AcetylationQARTQFIKQMAAGKQ
HHHHHHHHHHHCCHH		35.00-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DOM_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DOM_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DOM_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AGT2L_DROMECG8745physical
22036573
AN32A_DROMEMapmodulinphysical
22036573
VPS72_DROMEYL-1physical
22036573
NOTCH_DROMENgenetic
23550128
TIP60_DROMETip60genetic
23550128
ATG5_DROMEAtg5genetic
23550128
SBNO_DROMEsnogenetic
23550128
TOP1_DROMETop1genetic
26555684
AFF4_DROMElilligenetic
23550128
CHD1_DROMEChd1genetic
26555684
SMAL1_DROMEMarcal1genetic
26555684
SOSSB_DROMECG5181genetic
26555684
SMRCD_DROMEEtl1genetic
26555684
TRA1_DROMENipped-Agenetic
23550128
ECR_DROMEEcRgenetic
23550128
PABP2_DROMEPabp2genetic
23550128
ISWI_DROMEIswigenetic
26555684
MAM_DROMEmamgenetic
23550128
PCNA_DROMEPCNAgenetic
26555684
EMC_DROMEemcgenetic
23550128
HDAC1_DROMERpd3genetic
26555684
RS9_DROMERpS9genetic
26555684
APG12_DROMEAtg12genetic
23550128
BRM_DROMEbrmgenetic
26555684
RUVB2_DROMEreptgenetic
23550128
ASF1_DROMEasf1genetic
26555684
CHDM_DROMEMi-2genetic
26555684
PUM_DROMEpumgenetic
23550128
CAF1_DROMECaf1genetic
26555684
EAF3_DROMEMRG15genetic
23550128
DL_DROMEDlgenetic
23550128
INO80_DROMEIno80genetic
26555684
BECN1_DROMEAtg6genetic
23550128
ATRX_DROMEXNPgenetic
26555684
DCO_DROMEdcogenetic
23550128
LOLA1_DROMElolagenetic
23550128
LOLA2_DROMElolagenetic
23550128
LOLA3_DROMElolagenetic
23550128
LOLA4_DROMElolagenetic
23550128
LOLA6_DROMElolagenetic
23550128
LOLA5_DROMElolagenetic
23550128
PP2A_DROMEmtsgenetic
23550128
2ABA_DROMEtwsgenetic
23550128
2AAA_DROMEPp2A-29Bgenetic
23550128
ISWI_DROMEIswiphysical
18454204
E2F1_DROMEE2fphysical
17517653
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DOM_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-656; SER-664; SER-666;THR-729; SER-733; SER-736; SER-744 AND THR-838, AND MASS SPECTROMETRY.

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