CHD1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHD1_DROME
• UniProt AC: Q7KU24
• Protein Name: Chromodomain-helicase-DNA-binding protein 1
• Gene Name: Chd1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1883
• Subcellular Localization: Nucleus . Chromosome . Colocalizes with elongating RNA polymerase II (Pol II) on polytene chromosomes (PubMed:18202396).
• Protein Description: ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin remodeling, but also required to maintain a specific chromatin configuration across the genome (By similarity). Involved in assembly of active chromatin. Required for maintaining open chromatin and pluripotency in embryonic stem cells and is important for wing development and fertility. Is essential for the incorporation of histone H3.3 and assembly of paternal chromatin. Required for replication-independent nucleosome assembly in the decondensing male pronucleus..
• Protein Sequence: MSQALNESANSIGSDEQDDTREEANGTDHSGSGSGSGSSGSDSDSDSSSGNSSDGRSSPEPEDKSLSVAGFPPTAAAAQADSKTNGFTDDQEDSSSDGSSGSDSDSDAEGPSDQRNQSINNANTSSSLPKPEQNEEEDNETEAGQQQPASDASADESSDSSANVSPTSSSSSSEEEEEDYRPKRTRQARKPPTAAEKSKKAPAPKNKKKTWDSDESDESEDSDDEVSTAQKRKPAATTSRSKLAQQQQRRRVKPFSSEDSDDDDASKRCATRRKGAAVSYKEASEDEATDSEDLLEFEYDESQAATTAATAEEEEKCETIERILAQRAGKRGCTGNQTTIYAIEENGFDPHAGFDEKQTPDAETEAQFLIKWKGWSYIHNTWESEATLRDMKAKGMKKLDNFIKKEKEQAYWRRYAGPEDIDYFECQLELQHELLKSYNNVDRIIAKGSKPDDGTEEYLCKWQSLPYAESTWEDAALVLRKWQRCAEQFNDRESSKCTPSRHCRVIKYRPKFSRIKNQPEFLSSGLTLRDYQMDGLNWLLHSWCKENSVILADEMGLGKTIQTICFLYSLFKIHHLYGPFLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQYEWQFESSKRLKFNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDTNHRLLITGTPLQNSLKELWALLHFIMPDKFDTWENFEVQHGNAEDKGYTRLHQQLEPYILRRVKKDVEKSLPAKVEQILRVEMTSLQKQYYKWILTKNFDALRKGKRGSTSTFLNIVIELKKCCNHAALIRPSEFELMGLQQDEALQTLLKGSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLADYLQKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWNPQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMDTTGRTVLDKSGNGHSSNSNPFNKDDLSAILKFGAEELFKDEQEHDDDLVCDIDEILRRAETRNEDPEMPADDLLSAFKVASIAAFEEEPSDSVSKQDQNAAGEEDDSKDWDDIIPEGFRKAIDDQERAKEMEDLYLPPRRKTAANQNEGKRGAGKGGKGKQQADDSGGDSDYELGSDGSGDDGRPRKRGRPTMKEKITGFTDAELRRFIRSYKKFPAPLHRMEAIACDAELQEKPLAELKRLGEMLHDRCVQFLHEHKEEESKTAATDETPGAKQRRARATFSVKLGGVSFNAKKLLACEQELQPLNEIMPSMPEERQQWSFNIKTRAPVFDVDWGIEEDTKLLCGIYQYGIGSWEQMKLDPTLKLTDKILLNDTRKPQAKQLQTRAEYLLKIIKKNVELTKGGQRRQRRPRASRANDAKAASQSASSTIDAKPHDGEDAAGDARTVAESSNSQVDPSTASPHNAPATEQHGDPAKKAKKSKARSKKTSASDNNGNKPMHFTANNEPRALEVLGDLDPSIFNECKEKMRPVKKALKALDQPDVSLSDQDQLQHTRDCLLQIGKQIDVCLNPYAETEKKEWRSNLWYFVSKFTELDAKRLFKIYKHALKQKAGGDGEAKGKDKGSSGSPAKSKPNGVTTEEKEKERDRSGGKKKKKDKDKERSGQARYPETGIPTSGRYADPPLKRKRDENDADASSGLAGAPGGGIGDNLKSMSFKRLNMDRHEDRKKHHRGPDYYGGSGPPMGSGSYEGGSNSRRQGPTSPSTPRTGRGGYDPPPAPSGYTPEMERWQSRDRYSQDYKRDRYDGYGRSGGGQGSYHRERDRRPEKRRYPSGLPPHPYSSHYLPPNYYGLPNGAVPGLPPPSSVYRSDPRGYPVMPRDYPADYRRSDYERRTQT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	Phosphorylation	SPEPEDKSLSVAGFP CCCCCCCCCCCCCCC	37.89	22817900
67	Phosphorylation	EPEDKSLSVAGFPPT CCCCCCCCCCCCCCC	19.60	22817900
256	Phosphorylation	RRRVKPFSSEDSDDD HHCCCCCCCCCCCCC	41.15	19429919
257	Phosphorylation	RRVKPFSSEDSDDDD HCCCCCCCCCCCCCH	45.89	19429919
260	Phosphorylation	KPFSSEDSDDDDASK CCCCCCCCCCCHHHH	38.60	19429919
266	Phosphorylation	DSDDDDASKRCATRR CCCCCHHHHHHHHHH	27.85	18327897
1096	Phosphorylation	AAGEEDDSKDWDDII CCCCCCCCCCHHHHC	44.85	19429919
1155	Phosphorylation	GKQQADDSGGDSDYE CCCCCCCCCCCCCCC	45.27	18327897
1159	Phosphorylation	ADDSGGDSDYELGSD CCCCCCCCCCCCCCC	45.42	18327897
1165	Phosphorylation	DSDYELGSDGSGDDG CCCCCCCCCCCCCCC	51.96	18327897
1168	Phosphorylation	YELGSDGSGDDGRPR CCCCCCCCCCCCCCC	44.00	18327897
1749	Phosphorylation	NSRRQGPTSPSTPRT CCCCCCCCCCCCCCC	61.16	25749252
1750	Phosphorylation	SRRQGPTSPSTPRTG CCCCCCCCCCCCCCC	21.71	22817900
1784	Phosphorylation	WQSRDRYSQDYKRDR HHCCCCCCHHHHCCC	19.92	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHD1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHD1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHD1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SSRP1_HUMAN	SSRP1	physical	10199952

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.