SBNO_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SBNO_DROME
• UniProt AC: A8JUV0
• Protein Name: Protein strawberry notch
• Gene Name: sno {ECO:0000312|FlyBase:FBgn0265630}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1653
• Subcellular Localization: Nucleus .
• Protein Description: Notch pathway component, may contribute to the specificity between lateral and inductive Notch signaling pathways in the wing disk. Required during many developmental stages including oogenesis, embryogenesis and imaginal development of the eye, wing and leg. Ebi and sno regulate EGFR-dependent Delta transcription in the developing eye, by antagonizing a repressor function of Suppressor of Hairless (Su(H)). They are required in the R-cells for normal cone cell development..
• Protein Sequence: MTSKKRKTLLDADDDNDNFDEDDSGSDFDDDEDPDQIEVPGGGRDLNTAVTYAQNIRSGVGVAPKGGIPIPISGAKIVVGNNKIKPISLLRINNNNNNIVTSVNNRNNNNIISTNGSSNNNNNSINNNSQIIKTTTVTTTPTTVGATPTVGGVALGGKLTVIPIAGRNVALDNNLSNMPKKLNNMVTAMGSPAARSSGNAGTTGSSQGGAIGSTSSYLNSLTTNELMNLAAYVAAKGSNAPPPPPPSTAANSVRHSPTGGIPNPGGNFFGGSAAASTSASAANFNMAASLLAQMSYAGGASQIRALKVAGNIGGVGNNQKPPPIATTPGSGGPAGGAPGSGVKGNNSMMEAVQKLIAMNPEYLTSGIPNTVFQMFMQSMQRPQATPSPNQPMNPGAMVTSAAAAAAHASAVAYVQQEEDEVDYEEMGVAETYADYWPAKLKLGKKHPDAVVETASLSSVEPCDVYYKLSLPLETINSGHLSALQLESITYASQAHDHLLPDGSRAGFLIGDGAGVGKGRTIAGIIYENYLKGRKKALWISVSNDLKYDAERDLSDIGATRIEVHALNKFKYAKISSDVNNNCKRGVIFSTYSALIGESNNKTGKYRSRFRQLLQWCGEDFEGLIIFDECHKAKNLCPVGSGKPTKTGQTVLELQQKLPKARVVYASATGASEPKNMAYMVRLGLWGQGTAFGNFNDFITAVERRGVGAMEIVAMDMKLRGMYIARQLSFKGVSFKIEEVPLSKEFRKIYDQSVELWVEAMQKFTEAAELIDAESRMKKTMWGQFWSSHQRFFKYLCIAAKVNHAVLVARESIKYGKCVVIGLQSTGEARTLDQLERDDGELTDFVSTAKGVFQSFVERHFPAPDRNRINRILGLYDETPSLSSVADSTSSLSNNSNITTAAGKRKGSNNNDNRSTKIKKKKRSGSWECSDSEDENTDMKRNRKRDGGNSNSDSDEANSDDDLKSDIDDEDEDHDVDSDQRSVASDASSDFNPFFSGSDSDIDPWVNARSKKSKKAQKKSKKKVKKEKTKKEITTSSATDPSGSTAMSATVVAALNAVKNRKSQLSTQDKIQDLLQKKQELKGTVTPVGVNGVKLNYGPPPKDAIERACTMKEELLRKIERLGARLPPNTLDQLIDELGGPDNVAEMTGRRGRVVQTDDGSIQYESRTESDVPLETLNITEKQRFMDGEKDVAIISEAASSGISLQSDRRVFNQRRRVHITLELPWSADRAIQQFGRTHRSNQVNAPEYIFLISDLAGERRFASTVAKRLESLGALTHGDRRATETRDLSQFNIDNKYGRQALETVMRTIMGYESPLVPPPTDYSGEFFKDIAGALVGVGIIVNSESHPGVLSLDKDYNNISKFLNRILGCPVDLQNRLFKYFTDTMTAIIQQAKRGGRFDLGILDLGAAGENVTRVRLIRFVRKHATGVAPTEMHTVRVERGMIWQEAIDKYADLFNENEGFYLSHQLRNQKRTAIMVVILESRNSSSTSSTTDLDSGSKKKKTHSKKEIMCQIYRPNTGLQVRHESLFELEKKYRKVASEEAEPHWTEQYDASVNTCSHAYWNGNCRNVSLGNDCEVGLRQRLYHVLAGSVLSVWGRVEHILNTRSNSKMQVIRMKTTEGEKIVGTLIPKSCFEPLVADLRSDSEKQEEFNY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	DNFDEDDSGSDFDDD CCCCCCCCCCCCCCC	53.14	22817900
26	Phosphorylation	FDEDDSGSDFDDDED CCCCCCCCCCCCCCC	38.77	22817900
85	Acetylation	VVGNNKIKPISLLRI EECCCCCCCEEEEEE	37.60	21791702
326	Phosphorylation	QKPPPIATTPGSGGP CCCCCCCCCCCCCCC	5.11	21082442
327	Phosphorylation	KPPPIATTPGSGGPA CCCCCCCCCCCCCCC	23.76	21082442
506	Phosphorylation	LPDGSRAGFLIGDGA CCCCCCCCEEECCCC	33.95	19060867
507	Phosphorylation	PDGSRAGFLIGDGAG CCCCCCCEEECCCCC	19.34	19060867
929	Phosphorylation	RSGSWECSDSEDENT CCCCCCCCCCCCCCC	15.80	22817900
931	Phosphorylation	GSWECSDSEDENTDM CCCCCCCCCCCCCCC	32.19	22817900
964	Phosphorylation	NSDDDLKSDIDDEDE CCCCCHHHCCCCCCC	6.35	19429919
977	Phosphorylation	DEDHDVDSDQRSVAS CCCCCCCHHHHHHHH	3.74	19429919
1109	Phosphorylation	DAIERACTMKEELLR HHHHHHHHCHHHHHH	32.43	22817900
1111	Phosphorylation	IERACTMKEELLRKI HHHHHHCHHHHHHHH	30.56	22817900
1144	Phosphorylation	LGGPDNVAEMTGRRG HCCCCCHHHHHCCCC	47.28	22817900
1157	Phosphorylation	RGRVVQTDDGSIQYE CCCEEECCCCCEEEE	35.18	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SBNO_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SBNO_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SBNO_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOTCH_DROME	N	genetic	8287794
EBI_DROME	ebi	genetic	12230979
WNTG_DROME	wg	genetic	9171377
VG_DROME	vg	genetic	9171377
DL_DROME	Dl	genetic	12230979
HLES_DROME	H	genetic	8287794
HLES_DROME	H	genetic	9171377
CUT_DROME	ct	genetic	9171377

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24; SER-26; SER-1109 ANDSER-1111, AND MASS SPECTROMETRY.
PubMed: 18327897