EBI_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EBI_DROME
• UniProt AC: Q95RJ9
• Protein Name: F-box-like/WD repeat-containing protein ebi
• Gene Name: ebi
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 700
• Subcellular Localization: Nucleus .
• Protein Description: F-box-like component of E3 ubiquitin ligase complexes; involved in R7 photoreceptor cell differentiation, cone cell development and neuronal cell cycle control. E3 ubiquitin ligase complexes mediate ubiquitination and subsequent proteasomal degradation of target proteins. Required for specification of R7 photoreceptor cell fate in the eye by participating in the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk), a general inhibitor of photoreceptor differentiation. Required to block the S phase entry in the peripheral nervous system and central nervous system in a process that does not involve the degradation of ttk. Involved in cone cell development by preventing the transcriptional repression mediated by Su(H) on Dl, probably by participating in a E3 complex that contains sno and mediates the ubiquitination and subsequent proteasomal degradation of some component of the Su(H) repressor complex..
• Protein Sequence: MSFSSDEVNFLVYRYLQESGFLHSAYVFGIESHISQSNINGALVPPAALLTILQKGLLYTEVEWSVGEDGEVARPIEGLSLIDAVMPEVKPLKPIVKTEPGKPGAVDSSAPAGGNQNNNAKPEIKIEPGTGVAGSAGGNKIAGSTTGTSTPTDQSASEVDSSGNAANNAGGTYAGNNGAGGNQASTGGSNSTSTPAGGDLAAPGASQKKSQNSNEAGSSSSGNAGNANATSTDDAASSTSTNGNSSTSSSVEQPTSGLTPAGGTVSTSNPDAAASGGASTATGSKAPSGAVTIRVGAQGNNVQSGSSNAQSSAPSGTISSSTSGGAGTPAALVPMDIDENIEIPESKARVLRGHESEVFICAWNPSRDLLASGSGDSTARIWDMSDANTNSNQLVLRHCIQKGGAEVPSNKDVTSLDWNCDGSLLATGSYDGYARIWKTDGRLASTLGQHKGPIFALKWNKCGNYILSAGVDKTTIIWDASTGQCTQQFAFHSAPALDVDWQTNQAFASCSTDQRIHVCRLGVNEPIKTFKGHTNEVNAIKWCPQGQLLASCSDDMTLKIWSMNRDRCCHDLQAHSKEIYTIKWSPTGPGTNNPNTNLILASASFDSTVRLWDVERGSCIHTLTKHTEPVYSVAFSPDGKHLASGSFDKCVHIWSTQTGQLVHSYKGTGGIFEVCWNSKGTKVGASASDGSVFVLDLRKF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
102	Acetylation	IVKTEPGKPGAVDSS CEECCCCCCCCCCCC	51.50	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EBI_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EBI_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EBI_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PHYL_DROME	phyl	physical	11032805
MED17_DROME	MED17	physical	22036573
CPSF6_DROME	CG7185	physical	22036573
MED18_DROME	MED18	physical	22036573
MED8_DROME	MED8	physical	22036573
MED14_DROME	MED14	physical	22036573
MED6_DROME	MED6	physical	22036573
MED11_DROME	MED11	physical	22036573
MED7_DROME	MED7	physical	22036573
MED16_DROME	MED16	physical	22036573
MED23_DROME	MED23	physical	22036573
BAP60_DROME	Bap60	physical	22036573
MED15_DROME	MED15	physical	22036573
MED27_DROME	MED27	physical	22036573
MED4_DROME	MED4	physical	22036573
MED30_DROME	MED30	physical	22036573
MED10_DROME	MED10	physical	22036573
Y1505_DROME	CG11505	physical	22036573
MED25_DROME	MED25	physical	22036573
SINAL_DROME	sinah	physical	17561381
SINA_DROME	sina	physical	17561381
TTKB_DROME	ttk	physical	11032805
TTKA_DROME	ttk	physical	11032805
SINA_DROME	sina	physical	11032805
HEP_DROME	hep	genetic	22666340
JRA_DROME	Jra	genetic	22666340
RNO_DROME	rno	genetic	14704181
DIAP1_DROME	th	genetic	22666340
DL_DROME	Dl	genetic	12230979
OSA_DROME	osa	physical	22036573
CRB_DROME	crb	physical	27702784

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.