RNO_DROME - dbPTM
RNO_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RNO_DROME
UniProt AC Q7YZH1
Protein Name PHD finger protein rhinoceros
Gene Name rno
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 3241
Subcellular Localization Nucleus .
Protein Description May function as a negative regulator of the EGFR/Ras/MAPK signaling pathway during eye development..
Protein Sequence MSQRGKRGNQQHHQSHHPPPQQHQRKDVEPQPPPTKRRKGRPPNGATTAAVAEVTGSGPATGSERVPVLPLCKSKHEEPGAEAGGGGQGRAAAGATSTSKSKSTKLAKSASKCKSQGASSSSSWQARSVADIKMSSIYNRSSTEAPAELYRKDLISAMKLPDSEPLANYEYLIVTDPWKQEWEKGVQVPVNPDSLPEPCVYVLPEPVVSPAHDFKLPKNRYLRITKDEHYSPDLHYLTNVVALAENTCAYDIDPIDEAWLRLYNSDRAQCGAFPINATQFERVIEELEVRCWEQIQVILKLEEGLGIEFDENVICDVCRSPDSEEANEMVFCDNCNICVHQACYGITAIPSGQWLCRTCSMGIKPDCVLCPNKGGAMKSNKSGKHWAHVSCALWIPEVSIGCVDRMEPITKISSIPQSRWSLICVLCRKRVGSCIQCSVKPCKTAYHVTCAFQHGLEMRAIIEEGNAEDGVKLRSYCQKHSMSKGKKENAGSHGGGSASVASAMQKANRYGSGAGGGADDGNNACGTTGEDPRRRKNHRKTELTSEERNQARAQRLQEVEAEFDKHVNFNDISCHLFDVDDDAIVAIYNYWKLKRKSRHNRELIPPKSEDVEMIARKQEQQDMENHKLVVHLRQDLERVRNLCYMVSRREKLSRSLFKLREQVFYKQLGVLDEMRLEKQQTKQEQQQPVMDLNAVIYANDGPTLYDRFYSSVGGQTVPAQYQDLKYILEQLMGKLQSGKQGRGRASQSPNKRKQPAKASPNKKLNNGILSSRTSSPEKTVAGSKVGTTTSKVRSPPGKNPTGRRASKSSAAAATSTHNKSQFHSNIRSSTTSHSSSGTISSGNSSSANGTSSSDSSSGSDSGSESGSSSAGSGVSKRKSSSGSPLKKQSYARSVEQRQKQRQRRQNEAVAGASATYPDSRSASSSSDGEDERCRNRQEPERGARRGPIQSKSVPNRSQASRSKPTTEADVGEGTGASARRKLSTTTRGLAQMDKDADESVSSDESEELLPLRGERQRESTTTSGLATTGSAIGRNLGQHIYSDSESSSSEQEKDQEEQATVESNVSDSQNQQTIRTKAAMKEFVPGTAATTSSTSQAASSTSKAKNTREGKEGAASIGNSTKTKPNPNAKLYPADLLVVPQRQAAKKASENMRSTNLATTLQPDVSDRVREPDINSISGTAKSKVKDSSSRVSNEADKSSLEKVRPKEHLQKTVGKTSESAPAERGKRGRPPKVPKDARPPSITENDKPALPTHTQSKPPSVVATPVSAKSNFAVSLVPQRQAAKKAAEQLKSSKPVLESFSTGNDISDKETVTSATISGSGSSVPAASTPVKPTRRSSIKEAPITPKEPLSGRRKSKEDLLATPIKTTPLVKRRVVVPNLSSSSSGDSESSSSSSSSGSSSSSGGSDSDSESQASNSENPSSREPPVAPAKVPSDSSLVPKRSPRKSMDKPSALTIAPASVNVLNIPSTRSRQNSTTKSTKVALQKAVQSVEDDVKCTPKTNRLQGSMDECGKQVQLEQATKRATRGSKSRPPSPTAKSSPEKTVSRCKSRAEESPKKVANLEQEISQRKVASGKGTSSLDKLLNKKQQQMNHSAQATPPPISPTPPASETRIVKDQCDLKPDEVSIQQINLGADAQPEPDLDPESAAEAGELPMDIDEELTTAPTRTQLSASASKLADIIDDERPPAAPLPASPTPTPTSNDEMSDAGSDLSERRRMRWRSRRRRRRRSHEPDEEHTHHTQHLLNEMEMARELEEERKNELLANASKYSASTSSPAVTVIPPDPPEIIELDSNSAEQQQQHLHDQPLPPPLVVQSPAADVVPTVMQQQLLPSQRPLIEQLPVEHLPIVETILEMEDSKFANNFASNLASVLNPPNQMSLIGSSIDRSKQISEEDSIQATRNLLEKLRKTKRKAQDDCSSKEAVDLLPPTPAIPSVFPFHNAADPEDIIHAQKEQQHQQQQQLQSSQTCIYGNSSGPNSVASLTIKDSPMTANSGSYANSLTNTPNATPTNATMNNLGYQVNFPNSQPPPTLGLFLEKSPHQKGACPLSSNGGANVGQPAPTPDFVDLAAAAVKNTLGSFRGAATVPTQSGTGVNAKINDYDESTRMQSPFGGMPWNESDLIAERRSSSPSSVSESNDPPQPPPVVTATATTARSLAQLESCKNFFNSYPSGNAGPGTAANATAPFNHPPMVNGIDSIPMFNNTNTTQHQPTTPAHQQQQQRTPNNQYNGTIYPQLAGIMHPQTTPTEPPSSLYGNGGVGGAVQSTTLPPPAQVNQYPGTPYSATTLGMISVQQPALSTVPVQTATTPNNPFTLTSPIDGKMPTYPAQLLSSCAEAVVASMMPPTPPVTATAKDSPSKRTSVSGSNLSKKQTHKSPQLPQGKSPGKSPRQPLQPPTPPAPVPVVALPPTKYDPQTHTLQGKPRQRAPRGSGGSGAPGRGRGRGRGRGRGGGVTSGMAMVLPPPMSDYGSNTHIVNNLVGTPFEFNNEFDDMAGPGVENLQSLRDRRRSFELRAPRVQNKPTTTPTTATTTNPLLHPVLPGPVDMRTYNLGFEAPHSTASQEAYQNNLLGAFDSGTADQTLSEFNEEDERQFQSALRATGTGTSPSKQHSGPTALVAPPTGPNPTPAPNLLLHCTEANQMAPNVAATGAATHLVEGSLVEASLEATSEEVSIDSDSTIPHSKTSTSDARSQIKLKIKSPMAYPEHYNAMTNSSSLTLTSTLVQSSNVVQTTVSTSTVVSASSAVSGNSRRMRKKELLSLYVVQKDNHNDDSSCGLPAASDTLPLENLRKSEEEDELSGGNGTKRFKKNSSSRELRALDANLALVEEQLLSSGAGACGGGSSGDGRRRSACSSGSNNDNNGKTGAASSAGKRRGRSKTLESSEDDHQAPKLKIKIRGLTANETPSGVSSVDEGQNYSYEMTRRACPPKKRLTSNFSTLTLEEIKRDSMNYRKKVMQDFVKGEDSNKRGVVVKDGESLIMPQPPTKRPKSSKPKKEKKEKKRQKQQQLILSSSTTTMTTTLIENTASASPGDKPKLILRFGKRKAETTTRTASLEQPPTLEAPAPLRFKIARNSSGGGYIIGTKAEKKDESTADNTSPITELPLISPLREASPQGRLLNSFTPHSQNANTSPALLGKDTGTPSPPCLVIDSSKSADVHDSTSLPESGEAAMGVQSSLVNATTPLCVNVGNYENSNNSLPSASGTGSASSNSCNSNSINNNGSGGGRASGEGGLLPLKKDCEVR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
105AcetylationTSKSKSTKLAKSASK
CCCCHHHHHHHHHHH		54.2421791702
105AcetylationTSKSKSTKLAKSASK
CCCCHHHHHHHHHHH		54.24-
108AcetylationSKSTKLAKSASKCKS
CHHHHHHHHHHHHHH		57.92-
108AcetylationSKSTKLAKSASKCKS
CHHHHHHHHHHHHHH		57.9221791702
112AcetylationKLAKSASKCKSQGAS
HHHHHHHHHHHCCCC		45.45-
112AcetylationKLAKSASKCKSQGAS
HHHHHHHHHHHCCCC		45.4521791702
133AcetylationARSVADIKMSSIYNR
HHHHHHHCHHHHCCC		33.02-
133AcetylationARSVADIKMSSIYNR
HHHHHHHCHHHHCCC		33.0221791702
746PhosphorylationKQGRGRASQSPNKRK
CCCCCCCCCCCCCCC		29.8125749252
748PhosphorylationGRGRASQSPNKRKQP
CCCCCCCCCCCCCCC		28.1325749252
794PhosphorylationTTTSKVRSPPGKNPT
CCCCCCCCCCCCCCC		38.1322817900
1346PhosphorylationSIKEAPITPKEPLSG
CCCCCCCCCCCCCCC		27.5222817900
1352PhosphorylationITPKEPLSGRRKSKE
CCCCCCCCCCCCCHH		40.7522817900
1357PhosphorylationPLSGRRKSKEDLLAT
CCCCCCCCHHHHCCC		39.1922817900
1364PhosphorylationSKEDLLATPIKTTPL
CHHHHCCCCCCCCCC		26.0522817900
1456PhosphorylationMDKPSALTIAPASVN
CCCCCCEEECCCEEE		18.1418327897
1535PhosphorylationGSKSRPPSPTAKSSP
CCCCCCCCCCCCCCC		37.2527794539
1537PhosphorylationKSRPPSPTAKSSPEK
CCCCCCCCCCCCCCH		51.5622668510
1540PhosphorylationPPSPTAKSSPEKTVS
CCCCCCCCCCCHHHH		48.9722668510
1556PhosphorylationCKSRAEESPKKVANL
HHHHHHHCHHHHHCH		33.2622817900
1731PhosphorylationRRRRRRRSHEPDEEH
HHHHHHHCCCCCHHH		30.3222668510
2509PhosphorylationSLRDRRRSFELRAPR
HHHHHHHHCCCCCCC		22.6622668510
2880PhosphorylationGRSKTLESSEDDHQA
CCCCCCCCCCCCCCC		41.9825749252
2881PhosphorylationRSKTLESSEDDHQAP
CCCCCCCCCCCCCCC		35.3525749252
3089PhosphorylationKAEKKDESTADNTSP
ECCCCCCCCCCCCCC		38.7419429919
3090PhosphorylationAEKKDESTADNTSPI
CCCCCCCCCCCCCCC		35.6619429919
3094PhosphorylationDESTADNTSPITELP
CCCCCCCCCCCCCCC		36.1119429919
3095PhosphorylationESTADNTSPITELPL
CCCCCCCCCCCCCCC		22.1319429919
3104PhosphorylationITELPLISPLREASP
CCCCCCCCCCCCCCC		26.0919429919
3110PhosphorylationISPLREASPQGRLLN
CCCCCCCCCCCCCCC		17.0122817900
3129PhosphorylationHSQNANTSPALLGKD
CCCCCCCCHHHCCCC		14.1621082442
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RNO_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RNO_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RNO_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RBF_DROMERbfgenetic
19744473
DL_DROMEDlgenetic
19744473
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RNO_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1346; SER-1352;THR-1364; THR-1456; SER-2880; SER-2881; SER-3104 AND SER-3110, ANDMASS SPECTROMETRY.

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