dbPTM

DEL_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DEL_DROME
UniProt AC	Q9VIF5
Protein Name	Protein deadlock
Gene Name	del
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	981
Subcellular Localization	Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with the oocyte nucleus at midstages of oogenesis and with the centrosomes of early embryos (PubMed:16616913). Expressed in nuclear foci (PubMed:28847004).
Protein Description	Developmental protein involved in oogenesis. [PubMed: 16616913 Required for germline maintenance, stability of mitotic spindles, localization of patterning determinants, oocyte growth and fusome biogenesis in males and females]
Protein Sequence	MEKLDKIRMSQKLSCWQHILTTLGTSSKTEQEWNTFFKGFLESWRKPYCIQTSCDPSIPLRKELLVRPRKALQENPHGPGSTLPESPVFLEPINSTAPREHPSPSKSHSTGSTGCDPGNGERSPSVSNKNSKYKNPGNSKYAKIWKRSNNHTTSIFSKAQISKRRDKLSSTKKRPDTCAPTDDSRKNREPRACAPNKNIFKTRETNAPNLTKNSCALPNVLILSPNSASKITQRGHSVGQTQDYKASPGKIIKRVPRYSLQCLKKKTEKVHNKIMDKPKNKQQPQTPPPFLLNNEYTESSDDSDDQLPLSELSQKMKSNKLNTLFLSRNEDCSPAPEKVKLKGERPAQNKKEQLTWEPSILTNLTDLGKQVAEPLRKSVKKSAKQQKPRVRAPPQGKKTLPQLQTGLKTQDKQSTHEMISEQAKTISEASGQQTSQVQSSLSPNNIRNNSVKLISAKTLMPAQRSQDYSPNKMQVGQPLGFAIELPSPVDGKEASVEIDTQLVHTSKFLENMTRPSTVEVHKFDLMDIFMGENEKLDYEYDDDDVLSVAASWNGLDDENVPEDEPRKEAKTAEQLPKPEPSTETLKPIEKENAQKMQSIKSFQIPKLNAKNLKTQPSVMRSIYENEELEKNKVLAKPAPPSLVHQPLAESNRNQRDEATAARRAKETFPVFAPLYRVAPESAATLVSANSQQVIPQVYFSTSNQDGVNWIKDVFGIRCMQSVDNKCISINCDHTMNSLGEVQKRLMRMDEDTLLSLYRQTIRSFFLFQTYYTSFVDIFKFRNLWQYLLIMLVDCRLYKSISAPLLAHVYEALSKCGMQKEAVKRIMEHVWLPCKAHKYRDLMLTTLNILSNANWEDYCDKLTQLDKDYNFEIPHKNLITILKSSVDCSDKFANALKLITLHPNSIRTNETIMSILSNASKSYSYMHNESASASQGPPGAASFLAPPAAIQPPHTTVPNFGYLPNPSFHYSNEYAINIHNFD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
224	Phosphorylation	LPNVLILSPNSASKI CCCEEEECCCCCHHH	18.29	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DEL_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DEL_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DEL_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
TBA1_DROME	alphaTub84B	genetic	16616913
CUFF_DROME	cuff	physical	24906153

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DEL_DROME

Related Literatures of Post-Translational Modification