dbPTM

SEM1A_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SEM1A_DROME
UniProt AC	Q24322
Protein Name	Semaphorin-1A
Gene Name	Sema1a {ECO:0000312\|FlyBase:FBgn0011259}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	899
Subcellular Localization	Cell membrane Multi-pass membrane protein .
Protein Description	Involved in growth cone guidance through its role in axonal repulsion..
Protein Sequence	MLNSHNTNHNNNSASNSNYNKGHKMHLKSATAKATIMKHKLSKFYGYGWMQVFLLLTVLVIGNQSAWQENIRPKLYVELGPEDVLKFVGNESVVDHFKLVTKDGNSLLIGARNTVFNLSIHDLVEQQRLVWTSPEDDTKMCLVKGKDEEACQNYIRIMVVPSPGRLFVCGTNSFRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSDPIIYREPLQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINCGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSCHNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEENYFYQNVATGQHAACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNFEDIINAQYTVETLVMAVLAGSIFSLLVGFFTGYFCGRRCHKDEDDNLPYPDTEYEYFEQRQNVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPPPPNKMHSPKNTLRKPPMHQMHQGPNSETLFQFQPDGYNTQQSYRGRDNFGTLRSHQVMGDNYRRGDGFSTTRSVKKAVNNTNTRNRSLGRARRQPPRHGIVTQHRSNSPQQQQQQSQQPHSSSGSSPVMSNSSSSPAPPSSSPSPQESPKNCSYIYRD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	N-linked_Glycosylation	LTVLVIGNQSAWQEN HHHHHHCCCHHHHHC	33.85	-
90	N-linked_Glycosylation	DVLKFVGNESVVDHF HHHHHHCCCCHHCCE	34.31	-
117	N-linked_Glycosylation	GARNTVFNLSIHDLV ECCCEEEEEEHHHHH	4.71	-
187	N-linked_Glycosylation	TYIISDSNYTLEATK EEEEECCCEEEEECC	22.29	-
207	N-linked_Glycosylation	CPYDPRHNSTSVLAD CCCCCCCCCCCEEEC	4.62	-
311	N-linked_Glycosylation	SFLKSRLNCSIPGDY HHHHHHHCCCCCCCC	2.31	-
404	N-linked_Glycosylation	PRPGSCHNDSRALPD CCCCCCCCCCCCCCC	32.99	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SEM1A_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SEM1A_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SEM1A_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CADN2_DROME	CadN2	physical	21447707
CL190_DROME	CLIP-190	physical	21447707
TOR_DROME	Tor	physical	21447707
MPND_DROME	CG4751	physical	21447707
C2D1_DROME	l(2)gd1	physical	21447707
POE_DROME	poe	physical	21447707
EIF3A_DROME	eIF3-S10	physical	21447707
TONSL_DROME	CG7457	physical	21447707
CHRB_DROME	chrb	physical	21447707
EXOC1_DROME	Sec3	physical	21447707
FAT2_DROME	kug	physical	21447707
STUM_DROME	CG30263	physical	21447707
CAPZA_DROME	cpa	physical	21447707
RTEL1_DROME	CG4078	physical	21447707
FUTSC_DROME	futsch	physical	21447707
NDKA_DROME	awd	physical	21447707
MYSN_DROME	zip	physical	21447707
LAMA_DROME	LanA	physical	21447707
TENM_DROME	Ten-m	physical	21447707
CLOCK_DROME	Clk	physical	21447707
INSR_DROME	InR	physical	21447707
PH4H_DROME	Hn	physical	21447707
PPIA_DROME	Cyp1	physical	21447707
EXU_DROME	exu	physical	21447707
1433Z_DROME	14-3-3zeta	physical	21447707
CYA1_DROME	rut	physical	21447707
FAT_DROME	ft	physical	21447707
PTP10_DROME	Ptp10D	physical	21447707
TNNI_DROME	wupA	physical	21447707
LA_DROME	La	physical	21447707
GSTS1_DROME	GstS1	physical	21447707
CADF_DROME	tsr	physical	21447707
DIA_DROME	dia	physical	21447707
TAF1_DROME	Taf1	physical	21447707
HYD_DROME	hyd	physical	21447707
ISWI_DROME	Iswi	physical	21447707
RYR_DROME	RyR	physical	21447707
XPC_DROME	mus210	physical	21447707
VATA2_DROME	Vha68-2	physical	21447707
ATM_DROME	tefu	physical	21447707
TRA1_DROME	Nipped-A	physical	21447707
TRR_DROME	trr	physical	21447707
LVA_DROME	lva	physical	21447707
DOM_DROME	dom	physical	21447707
APLP_DROME	Rfabg	physical	21447707
PREP_DROME	CG3107	physical	21447707
SRRT_DROME	Ars2	physical	21447707
ANKHM_DROME	mask	physical	21447707
FAS2_DROME	Fas2	genetic	11014819
FAS2_DROME	Fas2	genetic	16611816
ITA2_DROME	if	genetic	23028146
PTK7_DROME	otk	genetic	11604138
RHO1_DROME	Rho1	genetic	20826677
NDST_DROME	sfl	genetic	23028146
UGDH_DROME	sgl	genetic	23028146
DALY_DROME	dally	genetic	23028146
ITBX_DROME	mys	genetic	23028146
DYN_DROME	shi	genetic	12835384
RG190_DROME	RhoGAPp190	physical	23177958

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SEM1A_DROME

Related Literatures of Post-Translational Modification