dbPTM

PTK7_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PTK7_DROME
UniProt AC	Q6AWJ9
Protein Name	Tyrosine-protein kinase-like otk {ECO:0000303\|PubMed:11604138, ECO:0000303\|PubMed:1371458, ECO:0000303\|PubMed:15456725}
Gene Name	otk {ECO:0000312\|EMBL:AAT94478.1, ECO:0000312\|FlyBase:FBgn0004839}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1033
Subcellular Localization	Cell membrane Single-pass type I membrane protein .
Protein Description	Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in the adult visual system to innervate the lamina layer; specific targeting of R1-R6 axons..
Protein Sequence	MTARMISICGLVMALMMASVLASSSRFQRVPQSQSVVENESVKFECESTDSYSELHYDWLHNGHRIAYDKRVHQIGSNLHIEAVRRTEDVGNYVCIATNLASGAREASPPAKLSVIYLESASVQLLGSNRNELLLKCHVEGASGDLEPLEIEWYRNSEKLSTWKNVQLDQHRLIIRQPGSEDDGLYRCTASNAAGRVMSKQGYVYQSSVKCLPRLPRRKNEKMMESWDKQTFLCRGKRGGAAGLEALPAAPEDLRIVQGPIGQSIIKEGEPTALTCLYELPDELKNQRIQLRWRKDGKLLRQVELGGSAPIPGHSFDSGKDALLREDARLVLHKQNGTLSFASIIASDAGQYQCQLQLEAHAPINSSPGILEVIEQLKFVPQPTSKNLELDAVVAKVHCKAQGTPTPQVQWVRDGENTTLPDHVEVDANGTLIFRNVNSEHRGNYTCLATNSQGQINATVAINVVVTPKFSVPPVGPIETSEQGTVVMHCQAIGDPKPTIQWDKDLKYLSENNTDRERFRFLENGTLEIRNVQVEDEGSYGCTIGNSAGLKREDVQLVVKTTGDGFAPEESGGDGFLVTRAVLITMTVALAYIVLVVGLMLWCRYRRQARKARLNDLSTKEAGGDQPDVAGNGKGSEQEPCLSKQHNGHSKSRSKSSGDAQKSDDTACSQQSRASKKSAHIYEQLALPRSGLSELIQIGRGEFGDVFVGKLKATLVTSPSDKDADTEKQHSNSENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSGLEQLVLVKALNKVKDEQACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFLLATAGKVNTATAGSSSPPPLTTSQVLAVAYQIARGMDAIYRARFTHRDLATRNCVISSEFIVKVSYPALCKDKYSREYHKHRNTLLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQATKLPHEELTNEQVVQRSQAGSLEWSVAEATPDSLREILLSCWVSNPKERPSFSQLGAALSKAMQSAEK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	N-linked_Glycosylation	QSQSVVENESVKFEC CCCCCCCCCCEEEEE	34.92	-
336	N-linked_Glycosylation	RLVLHKQNGTLSFAS EEEEECCCCCEEEEE	50.66	-
417	N-linked_Glycosylation	QWVRDGENTTLPDHV EEEECCCCCCCCCCE	43.84	-
429	N-linked_Glycosylation	DHVEVDANGTLIFRN CCEEECCCCCEEECC	39.25	-
444	N-linked_Glycosylation	VNSEHRGNYTCLATN CCCCCCCEEEEEEEC	28.97	-
457	N-linked_Glycosylation	TNSQGQINATVAINV ECCCCCEEEEEEEEE	22.98	-
512	N-linked_Glycosylation	DLKYLSENNTDRERF CHHHHHCCCCCHHHH	54.01	-
514	Phosphorylation	KYLSENNTDRERFRF HHHHCCCCCHHHHHH	48.27	22817900
524	N-linked_Glycosylation	ERFRFLENGTLEIRN HHHHHHHCCCEEEEE	51.39	19349973
663	Phosphorylation	SSGDAQKSDDTACSQ CCCCCCCCCCHHHHH	28.74	25749252
678	Phosphorylation	QSRASKKSAHIYEQL HHHHHHHHHHHHHHH	28.90	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PTK7_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PTK7_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PTK7_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SEM1A_DROME	Sema-1a	genetic	11604138
DSH_DROME	dsh	physical	21772251
WNT2_DROME	Wnt2	physical	25010066
PTK7_DROME	otk	physical	25010066
FRIZ2_DROME	fz2	physical	25010066
FRIZ_DROME	fz	physical	25010066

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PTK7_DROME

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."; Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.; Nat. Biotechnol. 27:378-386(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-524, AND MASSSPECTROMETRY.	19349973 [Abstract]
Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-678, AND MASSSPECTROMETRY.	18327897 [Abstract]