| UniProt ID | WNT2_DROME | |
|---|---|---|
| UniProt AC | P28465 | |
| Protein Name | Protein Wnt-2 | |
| Gene Name | Wnt2 | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 352 | |
| Subcellular Localization | Secreted, extracellular space, extracellular matrix. | |
| Protein Description | Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May function in gonadogenesis and limb development. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation.. | |
| Protein Sequence | MWKIHNKLLIYILWIMEIRLVSSFTSVMLCGRIPGLTPGQRNMCREMPDALIALGEGHQLGAQECQHQFRGHRWNCSEVWQRNVFAHVIPTASREAAYTYAIASAGAAYAVTAACARGNISTCGCDVRHKATPTGGGTPDEPWKWGGCSADVDFGMRYARRFMDARELERDSRTLMNLHNNRAGRTLVKKMLRTDCKCHGVSGSCVMKTCWKSLPPFRLVGDRLMLKYQKAKTVQAVKGKRGLRLVLSRKKHAGTARAQKPVLDWPKRMELIYLEASPNYCERSLQTGSQGTSGRTCQRTGHGPQSCDLLCCGRGHNTQHIRRTTQCRCQFRWCCEVKCDECDESYEEFTCK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 75 | N-linked_Glycosylation | QFRGHRWNCSEVWQR HHCCCCCCHHHHHHH | 21.28 | - | |
| 119 | N-linked_Glycosylation | TAACARGNISTCGCD HHHHHCCCCCCCCCC | 21.34 | - | |
| 202 | O-palmitoleoylation | DCKCHGVSGSCVMKT CCCCCCCCCCHHHHC | 29.58 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of WNT2_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WNT2_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WNT2_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| AXN_DROME | Axn | genetic | 10457025 | |
| PANG1_DROME | pan | genetic | 10457025 | |
| PANG2_DROME | pan | genetic | 10457025 | |
| FRIZ3_DROME | fz3 | physical | 12205098 | |
| FRIZ2_DROME | fz2 | physical | 12205098 | |
| FRIZ_DROME | fz | physical | 12205098 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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