TONSL_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TONSL_DROME
• UniProt AC: Q9VSA4
• Protein Name: Tonsoku-like protein
• Gene Name: CG7457
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1405
• Protein Sequence: MEEKRYLKRKEKARSDGNRDQVAVSCNQLGDFYNQQGKYTDAVREYVQEAQIYASMGKELETAKAKRMVGEMYTLLCDYDAAKDHINDYLKIAKRLKNQVEEQRAYATLGRVHLLHGQSLADSSASGSMEQLKLAEKNFLRSLLLIKDLSGQISKLEQLDMQARCYLNIGVVKEHMEAFQESIEYIDKAIKISKTHELWDLTHLCYISMSLLYICKKNDATAALRFCNMALEVAKRFPNKVKKICETLITKAEILIKAGDFASAKQILTKAYKKNTPDENDRVNIEKQLRIVVKVCQTLDELVLTSSVDYAKLKGLYEKLGDGCCHLMNYEKALTYYQKMLENAELNQESGKSLVPIYVSLYQTYRDNGQFDKALEYLWKEFELNQDAPSEAFTTLCTIAEICEQQSHPFWTVHDVYQKALRQADKAGSCSDKLVKIAMVRLRRLMLKHNMQVLVENLEADATAKGIDLDQEESVGDDEEESDGGGTAVQQNTPDWDDDFDLATLTDSDASDLDETEKPRPQRTTRGNRTLVIKKNNKGETQLHQACISGNLELVRRLIDQGHTVNVRDHAGWLPLHEACNHGYREIVELLLDKGAASAINDKGGTSCDGITPLFDACSNGFLDVAELLLDRGADATVRTDYNETCIAGLDKWRQGAQLVDGEQAQYAQLRERLLRTLSKVGICSDKNARPLTNFNAKRISREERGSMSEEEDEEEALHESNRRSLSHNRSGSEYGAKKSKSSTQPSASKEYRSVMAHLKRPNRLNDDPPSTSTLNKHKRNAFLSEDEVDADNWLIDDVGPERKRKRINSGDLSRRTSKENFQDTALSLPANWEDDLLQATPENEYSQRQKQMRKLTLSRSSSMSSNHSSSATSSRKKHQATLLDSGFSRFRSESPLGSESSQDGTTSLISVRTIEPDSTTSTIQVLISPAKSSPIKVQATPVLATTVSFKVKIQDELLLVPIERKKLQDINIRWLAEEAGRRYNKLTGLTPLLRLKTADGFAYEETDPVSVALEQNMLMASILDWKISPLSQRYEEMCLQMQKTVDNKVKLLLERSQNNNMLELSGLWMRAEKTEPIFKALLHQARLTVLDLSCNFIGNEGCQQLAKSLPTLLQLKALRLQCNAIGSHGLEALLCGQGMDKLELLEELNLNQNPLGNASVRILSKYCASPAGQALTCLQLAQCELTELQDFDLGFNKLTRFDISFNQLTQQSVRRLTDQLNSCRLEQLNLSYVRWPLDDASGFALSERLVTLFEGGTCERFVGVQLAGCGLNDAHMYNISQHLAKAKQLQMLDISDNSNLSGTTLGYILDELPQLRDLLAVNCTNLLDDIRLQKLEQLKQLPRRLELTVDEQVFSMPGALETLQSIWQLQFGDKAKMLTTSNSRKIGRRYKGLLKLLADGSDAE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
707	Phosphorylation	ISREERGSMSEEEDE CCHHHCCCCCCCHHH	25.92	19429919
709	Phosphorylation	REERGSMSEEEDEEE HHHCCCCCCCHHHHH	43.48	19429919
721	Phosphorylation	EEEALHESNRRSLSH HHHHHHHHHHHHCCC	25.53	19429919
810	Phosphorylation	RKRKRINSGDLSRRT HHCCCCCCCCCCCCC	31.17	19429919
814	Phosphorylation	RINSGDLSRRTSKEN CCCCCCCCCCCCHHH	25.18	22817900
863	Phosphorylation	LTLSRSSSMSSNHSS HHHHCCHHCCCCCCC	24.75	21082442
893	Phosphorylation	SGFSRFRSESPLGSE CCCCCCCCCCCCCCC	39.45	19429919
895	Phosphorylation	FSRFRSESPLGSESS CCCCCCCCCCCCCCC	27.03	19429919
899	Phosphorylation	RSESPLGSESSQDGT CCCCCCCCCCCCCCC	41.82	19429919
901	Phosphorylation	ESPLGSESSQDGTTS CCCCCCCCCCCCCEE	34.69	19429919
902	Phosphorylation	SPLGSESSQDGTTSL CCCCCCCCCCCCEEE	28.39	19429919
906	Phosphorylation	SESSQDGTTSLISVR CCCCCCCCEEEEEEE	22.85	19429919
907	Phosphorylation	ESSQDGTTSLISVRT CCCCCCCEEEEEEEE	27.37	19429919
908	Phosphorylation	SSQDGTTSLISVRTI CCCCCCEEEEEEEEE	24.44	19429919
911	Phosphorylation	DGTTSLISVRTIEPD CCCEEEEEEEEECCC	15.73	19429919
929	Phosphorylation	STIQVLISPAKSSPI CEEEEEEECCCCCCC	18.04	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TONSL_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TONSL_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TONSL_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of TONSL_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-707; SER-709; SER-893;SER-895; SER-899 AND SER-902, AND MASS SPECTROMETRY.
PubMed: 18327897