| UniProt ID | EXOC1_DROME | |
|---|---|---|
| UniProt AC | Q9VVG4 | |
| Protein Name | Exocyst complex component 1 | |
| Gene Name | Sec3 {ECO:0000312|FlyBase:FBgn0266669} | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 889 | |
| Subcellular Localization | ||
| Protein Description | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.. | |
| Protein Sequence | MLSIGAMANIKHTLQKELFLASGERLLSVVTVVKKKDKKPCYLCVVTTAPPVPVVTLCLIKQSEQREGEYKRKRSWQLDEIKWVDGRNEQFETHEFDLQLEKLYKWYALNPHERQNFLAVLNRQIQKSVRGQRAEFRNVPAAWLSEKSPEKVALGRAVQKTQHMDDEEDEEEEAQEFTALTDKEANELGKLFSECDFAIKDAEQFIEQLSRELHDLDGANMQSVLASEQKVLKMMEHIDNAISEADKFENRLDSYEDILGHVKETMEKIGGKNAMIEIANNNNIKLMKELNKVISQLDLPHSQQQALDEPDLKTANGRKAAIAAAQCLQQAMNSDIDPALLRLEAVQDQRKRFEKWKQKFSATVSRFMNNLFIHLGNEIGDMQVTSTELTLPNHSNVHRELTPYTELMHWTKAMDRKTYDGLMRVYTASLSKIYDRDVRNFFNLAKIQVTEKLRNSREDLDMSTSSRKSAVSTIPYGTLGINRDQWGPGVETADRMRFDALLEKVLAELEPIALQEQLFCINFFQMDVISPTTKNTQTTLEMEKAVDMTQSIISGAVSPSGDGVPQKRIDRQINEDVRKLMMGLFGCLEPELVSFIQSFERVDSFYSLYVFVRLTQHVMSAQDTHSFLSMTFASALVQVKRSFDRFMQNQLLSIREAKLHKRSKAILPYVENFENFAQTAEGIFRKSDRRTDMEKWYLQLVNAIFEGIQLHSQEHPKTPVQVVRMENYHHMYALLAQLKVPGLDALKKEAKKCYNDALKAYVTQYFGRPLEKLNQFFEGVQLKVAQGVKETEISYQMAFSKQELRKVIAQYPAREVKKGLENLYKKVEKHLSEEENLLQVVWHAMQEEFIAQYNYLEERIQKCYAGAMINLEFNIQDILAFFSDIARSH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 75 | Phosphorylation | GEYKRKRSWQLDEIK CCCCCCHHCCCCEEE | 23.39 | 19429919 | |
| 145 | Phosphorylation | NVPAAWLSEKSPEKV CCCHHHHCCCCHHHH | 32.07 | 19429919 | |
| 148 | Phosphorylation | AAWLSEKSPEKVALG HHHHCCCCHHHHHHH | 33.95 | 19429919 | |
| 456 | Phosphorylation | VTEKLRNSREDLDMS HHHHHHCCHHHHCCC | 30.52 | 19429919 | |
| 466 | Phosphorylation | DLDMSTSSRKSAVST HHCCCCCCCHHCCCC | 43.76 | 22668510 | |
| 469 | Phosphorylation | MSTSSRKSAVSTIPY CCCCCCHHCCCCCCC | 32.56 | 19429919 | |
| 472 | Phosphorylation | SSRKSAVSTIPYGTL CCCHHCCCCCCCCCC | 21.97 | 19429919 | |
| 551 | Phosphorylation | KAVDMTQSIISGAVS HHHHHHHHHHHCCCC | 16.84 | 21082442 | |
| 558 | Phosphorylation | SIISGAVSPSGDGVP HHHHCCCCCCCCCCC | 16.89 | 21082442 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EXOC1_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EXOC1_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EXOC1_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RG68F_DROME | RhoGAP68F | physical | 14605208 | |
| ACOX1_DROME | CG5009 | physical | 14605208 | |
| CCD22_DROME | CG9951 | physical | 14605208 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-145; SER-148 ANDSER-456, AND MASS SPECTROMETRY. | |
