POE_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: POE_DROME
• UniProt AC: Q9VLT5
• Protein Name: Protein purity of essence
• Gene Name: poe {ECO:0000312|EMBL:AAF52598.1, ECO:0000312|FlyBase:FBgn0011230}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 5322
• Protein Description: Has a role in growth of the perineurial glial layer of the larval peripheral nerve. [PubMed: 27552662 May have a role in male fertility and eye development or function]
• Protein Sequence: MSAHSGGTDWNSVVKALILNRTGALNKNEVVNLLKAITRCEHDFFEEESNFTQFYTAFAALAADKLMQIKTICQTQICQLHDATAVLIRFIIYRLPRVSVYETKWLLGALKMLCEGRECPASASSSMFDYNAVANVLKSCKHPESTTKSIMPSSSSSGSGASNDKESPKSEIKRSRSDLSSVILQQLIAPLEPGKMTWVPLSEEVTDCTEQILAANVEYFQEQNGVDTLLDVCVSLPILNRYRSKYMETINGGKSLYLPLTQVEATAVKSSMNHMLTDLTILSQAQALIEMQPLTPSRIERLSMCGIAALYNAVLTSIATSVLGMSQASSSQKQTASTSQGSGVGGSSGGQSNKDHDDFEDQACSIVNKALEIYSNIGHMFKTSARIHVYQNHLCYGSWLLISGIQGAMGASGSGGSSSDSASKSASKATKSGSEAGTAPTTPIARVNLFKVQQGFGELNAAIANHSIKLLSELIEDLKVEAACGQSLESTELPEPAQFDILQNYSSLERIVRVLNTATLHQLFTFLATVAYRKACTLKRASAKDRTECEPISYSDSTTYFNDSLSCSDNSEEDDSESYLGHWFKETLSPETHDDNANTSTQERAEQKSALVPKLDEPHEYLDLAADIFCFLDQFLANRHAYMQRYVKAGVSDQQMLLMANIIKDFDRDVMRNESDQGSGNAPAASAGAGTSAGASTKWQTSMIRFSGAAGRYIHNLISTSLLSEQLQSNLLQHLSISPWSTDTNTWPLQVYPSTLSVLVQILLLKPTQEKEAACLSVWHRLINTLVEGVCSSNTASDSDYEDLNIEHAQLLLFLFHSLNLMQKKSILLLTAGGVIRCAEVCRGISEDRPVKNSQIMLLSRLLLFLEYLMKHLYNAPPELLDQVRWNLFSVSSMPDTQKITDLLNCRTKLNSYCRHDIEENFRKSAGEYGSSIRPTFYSLVMGDPEISYWAQEFKLDGLAWNFILCTPDKLKYPLLVDALTDILSITDMSMYSKEKDKEASMHNLCAIQYCFTIAWKLNLGLPPSTSHVESLKAERSPNLHSLMWSIRLPLASSHYLVVSSLIKQGMYTQYAETLWTHVGDIGADIKYSLKQTILGVEAFNSQMNGNGTPRLSDLILFDSLVAHMQAVAWANKEGLKWPRKESEDAAGEQSAGTSLTSSSNDPELYSSNESIDDQKLKQDDDGKLSSDLQKYNQLVNELMVKLMNSYQLLSVIVRGQMLKQLSSSTPEKALNLIVPIVSDKPAIMLELHAAFLKLLPNEDKQLIANEWPKCLMVNDFAFNGKQHPVEPYILNVIDAHIIELTRGSNYSTLHTLKHCLKSILQLFELLLPHRTANAEVETQLKQLLISSMLDMRTDYLQGHSEHCLREILSGLTQEAQKLLLYEHMVGYCYRMLKEFAADLRQPQSAGPSGGAPLDQDRAMFNESMLFAVLKTMFKMLEKPVAVQAMRQFFKDQRSGSLTTLLLSFTGTSLPVSYARKMLQFVNRLFQLSLQADSQFQHEDLVECFSELATVDVARLKQWLGHIIYGPNVSTDVSTSEALDTTCRMLTSILQPSSSSSSNAQTPTNMATVSAMPSISDQLDPMEIEYDCGTAAGGGESNPGTGGAAANTSQILSLWQAAQPNPSEESSQACDHSDSERNGALLLSFVKSLVKDQSKASQIAPPLFQALLQLGQTLISPPQEGCDFADVLQIMITLADASPARGHVALFNTTLLWLELAKLQLPDKHLKHAENVSAQLRYLSELLQSIGFRGSRQHNPPWDDELQTDIDELYDELAEEGEQDSLLDDSDEDTLNNKLCTFSQTQKEFMNQHWYHCHTCNMINTVGVCSVCARVCHKGHDVSYAKYGNFFCDCGAKEDGSCQALSRRIGSNEVRDSAGIGSYLPSHMSLLAGKKRSSLPVGQPVLTRKDSLTNERIAVLTKLLEPYRETLQHQDQWLLVVRCILEYFDLLLPSINENCMLYSIVGCHKRATAALERLHLLEQSFQVTDQLMFATLGSQEGAFENVRMNYSGDQGQTIKHLLSSGVVRRVAFCCLSSPHGRRQQLAVSHEKGKVTILQLSALLKQADASKRKLTLTQLSSAPIACTVISLAANPCNEDCLAVCGLKECHILTFSSSGSTNEHIVVNPQLENGNYIKKAVWLPGSQTLLAVVTSDYVKIYDLAVDTYSPKYYYLVAVGKIRDCTFVYQDGNYNMLTFASSGYIYTQQLDQQSLAVHGDFYVTNTLELSHQHIKDIAGHIGGGGVSIYYSHTLQLLFYSYSCGRSFFSPLTNVSEGVKGIYHLDTNSASKSASKGPLQPLVQWTEVTGHPGLVYASMQTSNNPIILMITPERIYLQEIKAQSAKSRIMDVVGIRHAVAGVEKTTLLLLCEDGSLRIFSAQPEYTSFWLSPQVQPFGNQLYSSTLMAKGGGSGSTSKSKSNTASGKMTSRKASQQQKQPTAGGQPVFPIDFFEHCNMLADVEFGGNDLLQIYNKQKLKTRLFSTGMFVASTRSNGFTLEVINNDPNVVIVGIRVLIGTQDVQRAPQSVTILGRTIPTPVRRARWFDIPLTREEMLQSDKLLKVVFAKAPDPEHVTLLDCIEVYGKSKELVGWPDESEDVTVPGSSAPAVSSSQASSANFGEGFNCITQLDRMANHLLEVMDCALHLLGSGVPASMRQKAVKTASALLLLPTPNPVQTQARYVLATLYGTRALYHNYKDGVLLQFVNRELQSMQPKLEKLETLREIDPEAFYRLVLMVRGIANARPQSLAKICVENNYDIVPTLMGIVLELHKVTPTLDEPVNIVKRGLCQPETIVHCLVEIMYGFALADPGQVGRMTKYFIDLLKHDASVISHSAKEALILLLSPRMKRRKVAIVTPPACSTPTPSTSTMQALQAAASSAASDIIEEAAGVVVDGSVGGGGLPEPNADAEGAAVGVGGVGQQQMLNLEAFMGGGFPRLLGLPEDADDEAIMDIAIALSLQQHGGDANALQSLQQGLANLQGIRQATAMAAAVNAAANVSLGGSDDDEGSNVATDGSTLRTSPAEPAGSGGSESGGSGVESIGGTSARSSNFGDHANASPPRQGSTKDDQEQPGPSGVAGSGGVAVLSAMSSSEDNEANEDDKLSKLHDLRIAVLESIIQHLGTFDLCNGLQAIPLIQVILMLTTDLNGNNERDQQVLHDLLTALVDYVEIGKRGAAARMETKCPGNEVRLALLSLFGVLMGKTKSKQTGTTSPPHQFKDNSSFVASTTANVLSKSGAFVYALEALNTLLVHWKNVLGDPYAAGGGLASQSAQASGGASGPGVQLLKPIKHGPKPDISILIPHNYLKNYPDIFESYDGLLTEIIVRLPYQILRLSSAHPDNYDSGFCEAMTFTLCEYMMLNLNTLLRRQVRKLLMYICGSKEKFRMYRDGHSLDAHFRVVKRVCNIVSSKTGAPYNANPPMLSYDALVELTEHLRTCQEISQMRTGNWQKFCVVHEDALAMLMEIACYQLDDGVSPIIIQLLQAAVCNLPPPSGSKQAQPQPSTSSASGKLRTDREKSEDTDAYYSKFDPAQCGTFVHQIFRYACDALIIRFVRIFLLENNITQLRWQAHSFMTGLFEHANERQREKLLNIFWNLWPLVPTYGRRTAQFVDLLGYLTLSTRSITERLPEFVSRAVDVLRQQNELLCKHPNAPIYTTLESILQVNGYYLESEPCLVCNNPEVPMANIKLPSVKSDSKYTTTTMIYKLVQCHTISKLIVRIADLKRTKMVRTINVYYNNRSVQAVVELKNRPALWHKARSVSLQSAQTELKIDFPLPITACNLMIEFADFFETVSGSSENLQCPRCSAAVPAYPGVCGNCGENVFQCHKCRAINYDEKDPFLCHSCGFCKYAKFDFSMYARVCCAVDPIESAEDRVKTVSLIHSSLERADRNYRQLLTNKQMLELLIQKVAEHRSSDRMVEDNMASVHSTSQVNKIIQLLAQKYCVESRTSFEELSKIVQKVKACRSELVAYDRQQQDQPPVNPGSTTGAENPTTNRCYGCALASTEQCLTLLRAMAYNYDCRVCLYSQGLVSELAEHNLRRGTPLIQEEVRNLLVVLTKDNAEACMHLLQLVTTRVKNALMGSIPLISLEAAVHQEMTLLEVLLGQDDICWEYKLKVIFELFISNCRLPRGPVTAVLHPCLRIMQNLICPVLPGSKPNQKVATTDLCSMKMFEGNTVDYRAWLNSDRNHEYAAWSKRMPSNNQAKLKNAKDQNVAASGGSDAPPKSRREVRVAFLSEKYGKRWRERVLDKQRVIKPLVFNAKWIQPLLFNANSRFGRQLACSLLSSLSRTNERRQQALNMLTSFLKHVGEAGEASAEYLMLYKNMATEQPWLQYLVLKGVLSQISQLLAIEISKVHRMEEYSLSSDLSLGYALRQYVELLWLLLECPNIRRTYKTRMLGPVLESYLALRSLVVQRTRLIDDAQEKLLEMLEDMTSGTEEETRAFMEILIDTVEKTRMNDIKTPVFVFERLYSIIHPEEHDESEFYMTLEKDPQQEDFLQGRMLGNPYPSSEMGLGPLMRDVKNKICTDCELIALLEDDNGMELLVNNKIISLDLPVKDVYKKVWLAEGGDRDAMRIVYRMRGLLGDATEEFVETLNNKSQEQVDTEQLYRMANVLADCNGLRVMLERIGSLQRISRNRELIQVLLKLFLICVKVRRCQEVLCQPEIGAINTLLKVLQMCLQSENDSIQSAVTEQLLEIMETILSKAASDTLDSFLQFSLTFGGPEYVSALISCTDCPNVRNNPSVLRHLIRVLAALVYGNEVKMALLCEHFKDTLNFNRFDNERTPEEEFKLELFCVLTNQIEHNCIGGTLKDYIVSLGIVERSLAYITEHAPCVKPTLLRTDSDELKEFISRPSLKYILRFLTGLSNHHEATQVAISKDIIPIIHRLEQVSSDEHVGSLAENLLEALSTDSATAARVQQVRDFTRAEKKRLAMATREKQLDALGMRTNEKGQVTAKGSILQKIEKLRDETGLTCFICREGYACQPDKVLGIYTFTKRCNVEEFELKSRKTIGYTTVTHFNVVHVDCHTSAIRLTRGRDEWERASLQNANTRCNGLLPLWGPAVGEAAFSACMTRHSSYMQESTQRCDISYTSSVHDLKLLLVRFAWERSFHDDAGGGGPQSNMHFVPYLLFYSVYLLLSSRSAARDSKTLLTYLQAPPSEKWLECGYEVDGPLFMATISLSLHSRELWNKHKLAHLKRMIAVAQGRHVSPAVLCKALLAPADRQVKDYTVYKPFLMMWALVDLIYDNLFKTVSTPKEEDWPISLFDYLRKNDEALLKSTDSILQTLTEEFLPCTSFVEFCDVAGLLHLIEHPDNFIEEILAALPSTSSSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Acetylation	NRTGALNKNEVVNLL CCCCCCCHHHHHHHH	56.16	21791702
167	Phosphorylation	GASNDKESPKSEIKR CCCCCCCCCHHHHHC	43.28	30478224
175	Phosphorylation	PKSEIKRSRSDLSSV CHHHHHCCHHHHHHH	31.00	21082442
177	Phosphorylation	SEIKRSRSDLSSVIL HHHHCCHHHHHHHHH	44.12	19429919
180	Phosphorylation	KRSRSDLSSVILQQL HCCHHHHHHHHHHHH	27.78	21082442
441	Phosphorylation	SEAGTAPTTPIARVN CCCCCCCCCCCEEEE	42.62	28490779
442	Phosphorylation	EAGTAPTTPIARVNL CCCCCCCCCCEEEEE	16.19	21082442
587	Phosphorylation	LGHWFKETLSPETHD HHHHHHHCCCCCCCC	32.88	28490779
589	Phosphorylation	HWFKETLSPETHDDN HHHHHCCCCCCCCCC	28.27	28490779
599	Phosphorylation	THDDNANTSTQERAE CCCCCCCCHHHHHHH	30.64	29892262
600	Phosphorylation	HDDNANTSTQERAEQ CCCCCCCHHHHHHHH	28.09	22817900
1167	Phosphorylation	SNDPELYSSNESIDD CCCHHHHCCCCCCCH	39.03	22817900
1168	Phosphorylation	NDPELYSSNESIDDQ CCHHHHCCCCCCCHH	30.93	22817900
1171	Phosphorylation	ELYSSNESIDDQKLK HHHCCCCCCCHHHCC	35.25	22817900
1867	Phosphorylation	ALSRRIGSNEVRDSA HHHHHCCCCCCCCCC	27.69	21082442
1873	Phosphorylation	GSNEVRDSAGIGSYL CCCCCCCCCCCCCCC	20.17	21082442
1882	Phosphorylation	GIGSYLPSHMSLLAG CCCCCCHHHHHHHCC	29.27	21082442
1885	Phosphorylation	SYLPSHMSLLAGKKR CCCHHHHHHHCCCCC	18.14	21082442
1893	Phosphorylation	LLAGKKRSSLPVGQP HHCCCCCCCCCCCCC	45.14	19429919
1894	Phosphorylation	LAGKKRSSLPVGQPV HCCCCCCCCCCCCCC	40.50	19429919
2070	Phosphorylation	DASKRKLTLTQLSSA CHHHCCCCHHHHCCC	30.69	21082442
3013	Phosphorylation	TDGSTLRTSPAEPAG CCCCCEECCCCCCCC	42.02	18327897
3014	Phosphorylation	DGSTLRTSPAEPAGS CCCCEECCCCCCCCC	18.71	29892262
3042	Phosphorylation	GGTSARSSNFGDHAN CCCCCCCCCCCCCCC	30.53	21082442
3051	Phosphorylation	FGDHANASPPRQGST CCCCCCCCCCCCCCC	34.93	19429919
3057	Phosphorylation	ASPPRQGSTKDDQEQ CCCCCCCCCCCCCCC	24.76	22817900
3083	Phosphorylation	VAVLSAMSSSEDNEA HHHEECCCCCCCCCC	30.35	22817900
3203	Phosphorylation	TKSKQTGTTSPPHQF CCCCCCCCCCCCCCC	27.73	19429919
3204	Phosphorylation	KSKQTGTTSPPHQFK CCCCCCCCCCCCCCC	40.35	19429919
3205	Phosphorylation	SKQTGTTSPPHQFKD CCCCCCCCCCCCCCC	35.95	19429919
3510	Phosphorylation	LRTDREKSEDTDAYY CCCCHHHCCCCCHHH	35.63	19429919
3947	Acetylation	TSFEELSKIVQKVKA CCHHHHHHHHHHHHH	60.57	21791702
4590	Phosphorylation	VETLNNKSQEQVDTE HHHHCCCCHHHCCHH	40.86	19429919
4835	Phosphorylation	PTLLRTDSDELKEFI CEECCCCHHHHHHHH	32.16	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of POE_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of POE_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of POE_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
INE_DROME	ine	genetic	11517334

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-167; THR-599; SER-600;SER-1167; SER-1168; SER-1171; SER-1894; THR-3013; SER-3014; SER-3051;SER-3057 AND SER-3510, AND MASS SPECTROMETRY.
PubMed: 18327897

"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1894, AND MASSSPECTROMETRY.
PubMed: 17372656