| UniProt ID | NDST_DROME | |
|---|---|---|
| UniProt AC | Q9V3L1 | |
| Protein Name | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase | |
| Gene Name | sfl | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 1048 | |
| Subcellular Localization |
Golgi apparatus membrane Single-pass type II membrane protein. |
|
| Protein Description | Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in diffusion of morphogen wingless (wg) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis, HSPGs being required for movement of wg morphogens. Required for wg signaling during both embryonic and imaginal disk development. Also required for FGF receptor signaling.. | |
| Protein Sequence | MTISGGNQHNNNANRKYEKLIKQPQMQFGSSVTGTQTDVDSCRDADADANAVRQDFSNFNKHFGNGHAITDRTMLLRLEDDVTTAAGIVTYKGKSNGNGNGNGNGSIGSISLDFNGSPTSSTSIGIASGSSSNTHLASGGGVGGIGGSEPAGWMCHCCNLIARRCFGINVRRCVLALLAITMVSIFYYTHYVDTGVFNGLIQRDTHPAPIINCRMINSGGKHIRNASPAPDHRSEARLRIDPKVLVFVETTYSGLGRDIAELLVYNRIKYKIEVAGKSLPVLTNLDKGRYGVIVFENLDKYLNMDKWNRELLDKYCREYSVGIVGFVSPSEETLVGAQLRDFPLFVNTNLRLRDASLNPLSSVLRLTRAGETAWGALPGDDWAVFQHNHSTYEPVEWAQRNTQEYPADSVGQVQLPLTTVLQDRGQLDGIQRVLFGSSLRFWLHRLVFLDALSYLSHGQLSLNLERMILVDIDDIFVGEKGTRLRPDDVRALIATQKNIAAMVPGFRFNLGFSGKYYHHGTREENLGDDFLLQNVQEFNWFSHMWKHQQPHLYDNLTLLMAEMHLNYAFAVDHNIPTDSGYSISPHHSGVYPAHELLYMAWKKVWNVKVTSTEEYPHLRPARLRRGFIHRNIMVLPRQTCGLFTHTMYIDRYPGGRDKLDESIQGGELFQTIVYNPINIFMTHMSNYGSDRLALYTFQSVIKFLQCWTNLKLASAPPVQLAEMYFRLHPEEVDPVWGNPCDDVRHKKIWSKTKNCDSLPKFLVIGPQKTGTTALYTFLSMHGSIASNIASPETFEEVQFFNGNNYYRGLDWYMDFFPSESLPNTSSPMPTQLGSPRFMFEKSATYFDGEAVPKRSHALLPHAKIVTILISPAKRAYSWYQHQRSHGDVIANNYSFYQVITASDSAPRALKDLRNRCLNPGKYAQHLEHWLAYYPAQQLHIIDGEQLRLNPIDVMNELQRFLKIQPLLDYSNHLRYDVKKGFYCQAVSEKRNKCLGKSKGRQYPAMDERSAKLLQRYYLNHNTALVKLLKKLGSRPIPQWLKDDLSTGT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 388 | N-linked_Glycosylation | DWAVFQHNHSTYEPV CCEEEECCCCCCCCC | 21.74 | - | |
| 555 | N-linked_Glycosylation | QQPHLYDNLTLLMAE CCCHHHHHHHHHHHH | 22.74 | - | |
| 823 | N-linked_Glycosylation | FPSESLPNTSSPMPT CCCCCCCCCCCCCCC | 58.86 | - | |
| 892 | N-linked_Glycosylation | HGDVIANNYSFYQVI CCCEEECCCCEEEEE | 25.46 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NDST_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NDST_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NDST_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| FGFR1_DROME | htl | genetic | 10433902 | |
| HS2ST_DROME | Hs2st | genetic | 21147759 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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