| UniProt ID | FGFR1_DROME | |
|---|---|---|
| UniProt AC | Q07407 | |
| Protein Name | Fibroblast growth factor receptor homolog 1 | |
| Gene Name | htl | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 729 | |
| Subcellular Localization |
Membrane Single-pass type I membrane protein. |
|
| Protein Description | May be required for patterning of muscle precursor cells. May be essential for generation of mesodermal and endodermal layers, invaginations of various types of cells and CNS formation.. | |
| Protein Sequence | MAAAWSWRASHSTITMTSGSLVVLFLLLSIWQPAVQVEGRRQMANSQEMIKDHLGARSQNKTPAITNNANQSSTSSADLDDGAADDDDNKADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIANLDTPPSTSDEEEDETDNLQKWCNY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 70 | N-linked_Glycosylation | PAITNNANQSSTSSA CCCCCCCCCCCCCCC | 44.37 | - | |
| 96 | N-linked_Glycosylation | NKADLPVNVSSKPYW CCCCCCCCCCCCCCC | 26.47 | - | |
| 134 | N-linked_Glycosylation | ALGNPEPNITWYRNG ECCCCCCCEEEEECC | 42.53 | - | |
| 140 | N-linked_Glycosylation | PNITWYRNGTVDWTR CCEEEEECCEEEECC | 34.49 | - | |
| 171 | N-linked_Glycosylation | LVPGDCGNYTCKVCN CCCCCCCCEEEHHCC | 34.96 | - | |
| 207 | N-linked_Glycosylation | ILMTGPLNLTLVVNS EEEECCEEEEEEECC | 33.83 | - | |
| 213 | N-linked_Glycosylation | LNLTLVVNSTGSMHC EEEEEEECCCCCCCC | 26.78 | - | |
| 242 | N-linked_Glycosylation | VPCHGMTNCSNNRSI EECCCCCCCCCCCCE | 20.51 | - | |
| 246 | N-linked_Glycosylation | GMTNCSNNRSIIAED CCCCCCCCCCEECCC | 23.84 | - | |
| 282 | N-linked_Glycosylation | SNSLGQSNSTAYLRV CCCCCCCCCHHHHHH | 35.18 | - | |
| 587 | Phosphorylation | DIQSTDYYRKNTNGR CCCCCCCCCCCCCCC | 20.23 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FGFR1_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FGFR1_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FGFR1_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| USH_DROME | ush | genetic | 10861002 | |
| EGFR_DROME | Egfr | genetic | 11163263 | |
| SPY_DROME | sty | genetic | 10457022 | |
| FGFR2_DROME | btl | genetic | 15634694 | |
| SMN_DROME | Smn | genetic | 21300852 | |
| RAS1_DROME | Ras85D | genetic | 8957001 | |
| RAS1_DROME | Ras85D | genetic | 9621429 | |
| RAS1_DROME | Ras85D | genetic | 10597291 | |
| RAS1_DROME | Ras85D | genetic | 11124118 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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