EXU_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EXU_DROME
• UniProt AC: P28750
• Protein Name: Maternal protein exuperantia
• Gene Name: exu
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 532
• Protein Description: Ensures the proper localization of the mRNA of the bicoid gene to the anterior regions of the oocyte thus playing a fundamental role in the establishment of the polarity of the oocyte. May bind the bcd mRNA..
• Protein Sequence: MVADNIDAGVAIAVADQSSSPVGDKVELPAGNYILVGVDIDTTGRRLMDEIVQLAAYTPTDHFEQYIMPYMNLNPAARQRHQVRVISIGFYRMLKSMQTYKIIKSKSEIAALKDFLNWLEQLKTKAGPSSDGIVLIYHEERKFIPYMILESLKKYGLLERFTASVKSFANSINLAKASIGDANIKNYSLRKLSKILSTTKEEDAACSASTSGSGSGLGSGSSMVSDSVSISPRDSTVTNGDDKQSSKNAVQGKRELFDGNASVRAKLAFDVALQLSNSDGKPEPKSSEALENMFNAIRPFAKLVVSDVLELDIQIENLERQNSFRPVFLNYFKTTLYHRVRAVKFRIVLAENGFDLNTLSAIWAEKNIEGLDIALQSIGRLKSKDKAELLELLDSYFDPKKTTVKPVVKGNSNNNNNYRRRNRRGGRQSVKDARPSSSPSASTEFGAGGDKSRSVSSLPDSTTKTPSPNKPRMHRKRNSRQSLGATPNGLKVAAEISSSGVSELNNSAPPAVTISPVVAQPSPTPVAITASN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
235	Phosphorylation	VSISPRDSTVTNGDD EEECCCCCCCCCCCC	26.51	19429919
236	Phosphorylation	SISPRDSTVTNGDDK EECCCCCCCCCCCCC	35.32	19429919
436	Phosphorylation	SVKDARPSSSPSAST CHHHCCCCCCCCCCC	37.58	19429919
437	Phosphorylation	VKDARPSSSPSASTE HHHCCCCCCCCCCCC	49.29	19429919
438	Phosphorylation	KDARPSSSPSASTEF HHCCCCCCCCCCCCC	27.49	19429919
440	Phosphorylation	ARPSSSPSASTEFGA CCCCCCCCCCCCCCC	36.48	19429919
442	Phosphorylation	PSSSPSASTEFGAGG CCCCCCCCCCCCCCC	32.57	19429919
443	Phosphorylation	SSSPSASTEFGAGGD CCCCCCCCCCCCCCC	34.74	28490779
452	Phosphorylation	FGAGGDKSRSVSSLP CCCCCCCCCCCCCCC	34.23	19429919
454	Phosphorylation	AGGDKSRSVSSLPDS CCCCCCCCCCCCCCC	33.18	19429919
456	Phosphorylation	GDKSRSVSSLPDSTT CCCCCCCCCCCCCCC	27.66	19429919
457	Phosphorylation	DKSRSVSSLPDSTTK CCCCCCCCCCCCCCC	41.59	19429919
461	Phosphorylation	SVSSLPDSTTKTPSP CCCCCCCCCCCCCCC	35.72	19429919
465	Phosphorylation	LPDSTTKTPSPNKPR CCCCCCCCCCCCCCC	27.23	22817900
467	Phosphorylation	DSTTKTPSPNKPRMH CCCCCCCCCCCCCCC	46.46	1756733
482	Phosphorylation	RKRNSRQSLGATPNG CCCCCCHHCCCCCCH	27.88	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EXU_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EXU_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EXU_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JMJD6_DROME	PSR	physical	22036573
NCBP1_DROME	Cbp80	physical	22036573
CUP_DROME	cup	physical	14691132
GRK_DROME	grk	physical	23213441
BCD_DROME	bcd	physical	27376588
BCD_DROME	bcd	physical	7479884
IF4E_DROME	eIF-4E	physical	14691132

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-467, AND MASSSPECTROMETRY.
PubMed: 18327897