PTP10_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTP10_DROME
• UniProt AC: P35992
• Protein Name: Tyrosine-protein phosphatase 10D
• Gene Name: Ptp10D
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1990
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: May have a role in axon outgrowth and guidance..
• Protein Sequence: MLYQLSKATTRIRLKRQKAVPQHRWLWSLAFLAAFTLKDVRCADLAISIPNNPGLDDGASYRLDYSPPFGYPEPNTTIASREIGDEIQFSRALPGTKYNFWLYYTNFTHHDWLTWTVTITTAPDPPSNLSVQVRSGKNAIILWSPPTQGSYTAFKIKVLGLSEASSSYNRTFQVNDNTFQHSVKELTPGATYQVQAYTIYDGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPYPAGIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQAAFKGLVPGRAYNISVQTMSEDEISLPTTAQYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQVSVATTRRQSTVPRSNEPVAFFDFRDIAEPGKTFNVIVKTVSGKVTSWPATGDVTLRPLPVRNLRSINDDKTNTMIITWEADPASTQDEYRIVYHELETFNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESNETSIFVVTRPSSPIIEDLKSIRMGLNISWKSDVNSKQEQYEVLYSRNGTSDLRTQKTKESRLVIKNLQPGAGYELKVFAVSHDLRSEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPPESGEFTEYSIRYRTDSEQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSFGVESPVPQEVNTTVPPNPVSNIIQLVDSRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGILSGITSLYPRTMPLIQSDVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVPGRLYNITVWTVSGGVASLPIQRQDRLYPEPITQLHATNITDTEISLRWDLPKGEYNDFDIAYLTADNLLAQNMTTRNEITISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPGRVERFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDAGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKNASGLEMPSWLDVQSYSVWLPYQAIDPYYPFENRSVEDFTIGTENCDNHKIGYCNGPLKSGTTYRVKVRAFTGADKFTDTAYSFPIQTDQDNTSLIVAITVPLTIILVLLVTLLFYKRRRNNCRKTTKDSRANDNMSLPDSVIEQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVGPAREMHDNEGYEGQQVQLDENGDVVATIEGHLSHHDLQQAEAEAIDDENAAILHDDQQPLTSSFTGHHTHMPPTTSMSSFGGGGGGHTNVDAPDRXHSVVNQSDNNNSVVIVLVDNKPSSMICKDSKGGNIDVLESQQQQQQQQQQQPNQGGHNITTISAINGYNTLQHRRKSQLITFSSSSCDIKNSLSHEYINGSNGSAANGPPSSGSGSGSGPGSNRASRANVRLSFAEEDVMILPQNHSQQSNHQDDEVFTRRRSLLEVEIGVEVGEDGELAPHEMEEDLEEEDEDEELYMHDEFETHIDTKSNNANDDSGGGSYEDSHALHSSLGGSNRNSLEKDDDDIEVDVISTDVSCYDQLLGSSCNTRNGDDDDIATLVGDGDYSTTKLSKASRLSGAGVGGLVVSGGGGGTAIGGGIAVNGGGVLGNGVGSEAGGGIIYANPFMDDEGIAESGM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
75	N-linked_Glycosylation	PFGYPEPNTTIASRE CCCCCCCCCEEECCH	48.47	-
106	N-linked_Glycosylation	NFWLYYTNFTHHDWL EEEEEEECCCCCCEE	24.57	-
128	N-linked_Glycosylation	TAPDPPSNLSVQVRS ECCCCCCCEEEEEEC	41.95	-
169	N-linked_Glycosylation	SEASSSYNRTFQVND CCCCCCCCCEEEECC	38.16	-
212	N-linked_Glycosylation	SVAYTSRNFTTKPNT EEEEEECCCCCCCCC	38.08	-
229	N-linked_Glycosylation	KFIVWFRNETTLLVL EEEEEECCCCEEEEE	41.30	-
259	N-linked_Glycosylation	SIEPPDANDSVLYVE EECCCCCCCCEEEEE	49.85	-
289	N-linked_Glycosylation	LVPGRAYNISVQTMS CCCCCEEEEEEEECC	21.05	-
317	N-linked_Glycosylation	TVPLRPLNVTFDRDF ECCCCCCEEEECCCC	33.20	-
471	N-linked_Glycosylation	ESLLPGRNYSLSVQA HHHCCCCCEEEEEEE	36.34	-
486	N-linked_Glycosylation	VSKKMESNETSIFVV HHHHCCCCCCEEEEE	43.17	-
512	N-linked_Glycosylation	KSIRMGLNISWKSDV HHCCCCCCCEECCCC	22.10	-
533	N-linked_Glycosylation	YEVLYSRNGTSDLRT EEEEECCCCCCCCCC	52.75	-
588	N-linked_Glycosylation	VYPNPPRNMTIETVR ECCCCCCCCEEEEEE	37.41	-
668	N-linked_Glycosylation	SPVPQEVNTTVPPNP CCCCCCCCCCCCCCC	29.31	-
687	N-linked_Glycosylation	IQLVDSRNITLEWPK EEEEECCCCEEECCC	35.23	-
719	N-linked_Glycosylation	PGRVQTKNVSENKSA CCCCEECCCCCCCCH	46.03	-
723	N-linked_Glycosylation	QTKNVSENKSADDLS EECCCCCCCCHHHHH	35.76	-
823	N-linked_Glycosylation	RDKEKLANDTDRKVT CCHHHHCCCCCCCEE	64.25	-
841	N-linked_Glycosylation	LVPGRLYNITVWTVS ECCCCEEEEEEEEEE	28.22	-
874	N-linked_Glycosylation	ITQLHATNITDTEIS CCEEEEECCCCCEEE	35.63	-
908	N-linked_Glycosylation	ADNLLAQNMTTRNEI HHHHHHCCCCCCCCE	24.94	-
925	N-linked_Glycosylation	SDLRPHRNYTFTVVV HHCCCCCCEEEEEEE	36.84	-
1001	N-linked_Glycosylation	IAYTNINNLTDAGMQ EEEEECCCCCCCCCC	40.29	-
1104	N-linked_Glycosylation	VAEDDAKNASGLEMP EECCCCCCCCCCCCC	40.85	-
1136	N-linked_Glycosylation	DPYYPFENRSVEDFT CCCCCCCCCCCCCEE	41.74	-
1195	N-linked_Glycosylation	PIQTDQDNTSLIVAI CEEECCCCCEEEEEC	26.40	-
1240	Phosphorylation	SRANDNMSLPDSVIE CCCCCCCCCCHHHHH	42.90	25749252
1244	Phosphorylation	DNMSLPDSVIEQNRP CCCCCCHHHHHCCCC	24.05	25749252

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTP10_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTP10_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTP10_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTP10_DROME	Ptp10D	physical	7961789
ENA_DROME	ena	physical	10069336
EGFR_DROME	Egfr	physical	19675131
SAS_DROME	sas	physical	23764287

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.