SAS_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAS_DROME
• UniProt AC: Q04164
• Protein Name: Putative epidermal cell surface receptor
• Gene Name: sas
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1693
• Subcellular Localization: Apical cell membrane ; Single-pass type I membrane protein.
• Protein Description: Vital for larval development. [PubMed: 1339334 During salivary tube elongation, possibly modulates cellular adhesion between the apical surface and apical extracellular matrix, and acts as an apical membrane determinant that functions in apical membrane expansion independently of crb and Cad99C]
• Protein Sequence: MQTCRRRKASGGQSTIKWSRMCLATLCGLLLLGIQIERAASAPAGEDAAATTMPPLDTTTDAPDAVAATTTPATTAAEQSSSISSITTEAADGSTTSTTTTTEAANKSNATETDFTTNVPVASSLPEETSVRSTSIEPITSTEPTTTPRQETEGPDQHMVFSNTEPDQSHIQHIPLRDEHAESSGADDATTEMQRQREQDQQQNELNQISNEQDDVVKDLNNFRHPATLITASNSNSEENVEIESDKQVETTTTAVPAAATSTSTEATGTPPTGTPATSTSTVPNEREEDPYHVHILSENHDRLAEHEDYQMLSTSTEESSTTSTTSTTNSTTESGIVAGIVVSQENKATAEPSTATESTSISTSTTTAATAATSTTSRARAMHMNDPEDEAATTIMPDSESVPVINIVEGQHMLQQEDQKDEEEEGVVKESESSSTTEASTTTTEPSPFVAFAGEGRSAGGGNDIELFLHHNGSTHEQLMDLSDVSMDGDQNEGSSKTESSTTSTTTTTAQPETEMPKIVEITASGDTMQRECLANNKSYKHGELMERDCDERCTCNRGDWMCEPRCRGLSYPRGSQRSMANPNCLEKMVEEDECCRVMECSEPQLEPTVVATEGAAPSTNGTGESAVTLPTTDDEATPKPRTDCHYNSGVYKFRERLEIGCEQICHCAEGGVMDCRPRCPERNHTRLDKCVYVKDPKDVCCQLELCDVTLDDHEQQPTPLQSNNNEDPEEIDPFRFQEQARDAGGAKPTCTFKGAEYDVGQQFRDGCDQLCICNEQGIHCAKLECPSNFGLDVQDPHCIRWEPVPADFKPSPPNCCPESMRCVDNGTCSYQGVQIENWSPVPANLTGCDQHCYCENGRVECRAACPPVPALPPADLPCHPALARLLPIPDDECCKHWMCAPQIPKIGGAGQDEETEATSTHSSIPANETTTTTATANKSTSIPSKVPQIKKDEEKRPPASGAFYPTLDGKPPKSIGGLGIFEKPEKPEKAHKKVQHQQQQHQQQEQQEQQQHQNDVIFDGDRTEEQEEPLPPNGGFVPFQFGQQHPHQPHLGPYGFYNPVKPVYEDYNPYEPYDINPNGTPQGKPPPVPTSQSDLFNILGAEQPGHPVHPGHGGPPRIHPGQTQKDNHNLGPQVRIEQILQHLQQTVPGGPPPPPPHQQHQSLTPQLHPQQQQISQQHPGHYVPIVHSGVPPPPPGHGIAIVDGQTVAYESYPVIPGLGVPQHHPQQHQTTPQQHLQQTILPSSSTTSGLSTQASEHSLHQNQGKLAKQQQSGANNLQPDIEVHTLEAIDPRSIRIVFTVPQVYVNLHGRVELRYSNGPSNDTSTWEQQIFAPPEDLIATSQMEFDLPSLEPNSLYKVKITLILRDLNSQPTSSIYTVKTPPERTITPPPPFPDYRPDFQDIFKNVEDPELTVSETNASWLQLTWKKLGDDQMEYVDGVQLRYKELTGMIYSSTPLIHRTLTSYTIQNLQPDTGYEIGLYYIPLAGHGAELRAGHMIKVRTAQKVDVYGFDVTVNVTKVKTQSVEISWNGVPYPEDKFVHIYRAIYQSDAGKEDSSVFKVAKRDSTTGTLIMDLKPGTKYRLWLEMYLTNGNTKKSNVVNFITKPGGPATPGKTGKLLTAGTDQPVGDYYGPLVVVSVIAALAIMSTLALLLIITRRRVHQTASITPPRKSDAAYDNPSYKVEIQQETMNL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
106	N-linked_Glycosylation	TTTTEAANKSNATET EECHHHHHHCCCCCC	56.17	-
109	N-linked_Glycosylation	TEAANKSNATETDFT HHHHHHCCCCCCCCC	53.11	-
330	N-linked_Glycosylation	TSTTSTTNSTTESGI CCCCCCCCCCCCCEE	37.13	-
473	N-linked_Glycosylation	IELFLHHNGSTHEQL CEEEEECCCCCHHHH	35.05	-
538	N-linked_Glycosylation	QRECLANNKSYKHGE HHHHHHCCCCCCCCC	29.10	-
622	N-linked_Glycosylation	EGAAPSTNGTGESAV CCCCCCCCCCCCCCE	50.82	-
685	N-linked_Glycosylation	RPRCPERNHTRLDKC CCCCCCCCCCCCCCC	38.94	-
827	N-linked_Glycosylation	ESMRCVDNGTCSYQG CCCEEEECCCEEEEC	27.55	-
846	N-linked_Glycosylation	NWSPVPANLTGCDQH CCCCCCCCCCCCCCC	31.87	-
929	N-linked_Glycosylation	THSSIPANETTTTTA CCCCCCCCCCEECEE	41.62	-
939	N-linked_Glycosylation	TTTTATANKSTSIPS EECEEECCCCCCCCC	34.16	-
1323	N-linked_Glycosylation	RYSNGPSNDTSTWEQ EECCCCCCCCCCCEE	60.76	-
1419	N-linked_Glycosylation	ELTVSETNASWLQLT CCCEECCCCHHHHHH	28.11	-
1517	N-linked_Glycosylation	YGFDVTVNVTKVKTQ EEEEEEEEEEEEEEE	26.78	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAS_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAS_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAS_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTP10_DROME	Ptp10D	genetic	23764287
PTP69_DROME	Ptp69D	genetic	23764287
PTP10_DROME	Ptp10D	physical	23764287

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.