dbPTM

PTP69_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PTP69_DROME
UniProt AC	P16620
Protein Name	Tyrosine-protein phosphatase 69D
Gene Name	Ptp69D
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1462
Subcellular Localization	Membrane Single-pass type I membrane protein.
Protein Description	Possible cell adhesion receptor..
Protein Sequence	MALLYRRMSMLLNIILAYIFLCAICVQGSVKQEWAEIGKNVSLECASENEAVAWKLGNQTINKNHTRYKIRTEPLKSNDDGSENNDSQDFIKYKNVLALLDVNIKDSGNYTCTAQTGQNHSTEFQVRPYLPSKVLQSTPDRIKRKIKQDVMLYCLIEMYPQNETTNRNLKWLKDGSQFEFLDTFSSISKLNDTHLNFTLEFTEVYKKENGTYKCTVFDDTGLEITSKEITLFVMEVPQVSIDFAKAVGANKIYLNWTVNDGNDPIQKFFITLQEAGTPTFTYHKDFINGSHTSYILDHFKPNTTYFLRIVGKNSIGNGQPTQYPQGITTLSYDPIFIPKVETTGSTASTITIGWNPPPPDLIDYIQYYELIVSESGEVPKVIEEAIYQQNSRNLPYMFDKLKTATDYEFRVRACSDLTKTCGPWSENVNGTTMDGVATKPTNLSIQCHHDNVTRGNSIAINWDVPKTPNGKVVSYLIHLLGNPMSTVDREMWGPKIRRIDEPHHKTLYESVSPNTNYTVTVSAITRHKKNGEPATGSCLMPVSTPDAIGRTMWSKVNLDSKYVLKLYLPKISERNGPICCYRLYLVRINNDNKELPDPEKLNIATYQEVHSDNVTRSSAYIAEMISSKYFRPEIFLGDEKRFSENNDIIRDNDEICRKCLEGTPFLRKPEIIHIPPQGSLSNSDSELPILSEKDNLIKGANLTEHALKILESKLRDKRNAVTSDENPILSAVNPNVPLHDSSRDVFDGEIDINSNYTGFLEIIVRDRNNALMAYSKYFDIITPATEAEPIQSLNNMDYYLSIGVKAGAVLLGVILVFIVLWVFHHKKTKNELQGEDTLTLRDSLSRALFGRRNHNHSHFITSGNHKGFDAGPIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESLKRKPNEGKCKLEVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPRKCPRYWADDEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPTVDGEVPEVCRGIIELVDQAYNHYKNNKNSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSDLHHIAESTLD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	N-linked_Glycosylation	EWAEIGKNVSLECAS HHHHHCCCEEEEECC	24.32	-
58	N-linked_Glycosylation	AVAWKLGNQTINKNH CEEHHHCCCEECCCC	46.38	19349973
64	N-linked_Glycosylation	GNQTINKNHTRYKIR CCCEECCCCCEEEEE	36.96	-
82	Phosphorylation	LKSNDDGSENNDSQD CCCCCCCCCCCCHHH	44.11	27794539
85	N-linked_Glycosylation	NDDGSENNDSQDFIK CCCCCCCCCHHHHHH	46.38	-
87	Phosphorylation	DGSENNDSQDFIKYK CCCCCCCHHHHHHHH	33.50	27794539
109	N-linked_Glycosylation	VNIKDSGNYTCTAQT EEECCCCCEEEEEEC	32.65	-
119	N-linked_Glycosylation	CTAQTGQNHSTEFQV EEEECCCCCCEEEEE	32.21	-
162	N-linked_Glycosylation	LIEMYPQNETTNRNL HHHCCCCCCCCCCCC	44.04	-
191	N-linked_Glycosylation	FSSISKLNDTHLNFT HHHHHCCCCCEECEE	56.74	-
196	N-linked_Glycosylation	KLNDTHLNFTLEFTE CCCCCEECEEEEEEE	21.91	-
209	N-linked_Glycosylation	TEVYKKENGTYKCTV EEEEEHHCCEEEEEE	57.92	-
255	N-linked_Glycosylation	GANKIYLNWTVNDGN CCCEEEEEEEECCCC	18.53	-
288	N-linked_Glycosylation	TYHKDFINGSHTSYI EEEECCCCCCCCEEE	46.00	-
302	N-linked_Glycosylation	ILDHFKPNTTYFLRI ECCCCCCCCEEEEEE	45.72	-
429	N-linked_Glycosylation	GPWSENVNGTTMDGV CCCCCCCCCCEECCC	54.39	-
442	N-linked_Glycosylation	GVATKPTNLSIQCHH CCCCCCCCCEEEEEC	40.08	-
451	N-linked_Glycosylation	SIQCHHDNVTRGNSI EEEEECCCCCCCCCE	32.47	-
516	N-linked_Glycosylation	ESVSPNTNYTVTVSA HCCCCCCCEEEEEEE	36.80	-
613	N-linked_Glycosylation	YQEVHSDNVTRSSAY EHHHHCCCCCHHHHH	39.82	19349973
701	N-linked_Glycosylation	DNLIKGANLTEHALK CCCCCCCCHHHHHHH	57.05	19349973
755	N-linked_Glycosylation	GEIDINSNYTGFLEI CEEECCCCCCEEEEE	33.62	-
1372	Phosphorylation	IELVDQAYNHYKNNK HHHHHHHHHHHHCCC	9.24	22817900
1375	Phosphorylation	VDQAYNHYKNNKNSG HHHHHHHHHCCCCCC	16.27	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PTP69_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PTP69_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PTP69_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTP99_DROME	Ptp99A	genetic	8598046
PTP99_DROME	Ptp99A	genetic	10648238
LAR_DROME	Lar	genetic	11683993
PTP99_DROME	Ptp99A	genetic	12807778
ENA_DROME	ena	physical	10069336

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PTP69_DROME

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."; Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.; Nat. Biotechnol. 27:378-386(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-58; ASN-613 AND ASN-701,AND MASS SPECTROMETRY.	19349973 [Abstract]