| UniProt ID | PTP99_DROME | |
|---|---|---|
| UniProt AC | P35832 | |
| Protein Name | Tyrosine-protein phosphatase 99A | |
| Gene Name | Ptp99A | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 1301 | |
| Subcellular Localization |
Membrane Single-pass type I membrane protein. |
|
| Protein Description | May play a key role in signal transduction and growth control. May have a role in the establishment of the intersegmental and segmental nerves.. | |
| Protein Sequence | MPRPQHHALLRAMLKLLLFASIAEHCATALPTNSSNSPSSPSPFTVASLPPTTASSSSSPAVISTSSFDRNLADLVNPEAETSGSGWESLETEFNLATTVDSSTQKTAKEPVLGTAATSIEQQDQPPDVPATTLAFANAFPVPVAGEMGNGNGNYNDATPPYAAVDDNYVPSKPQNLTILDVSANSITMSWHPPKNQNGAIAGYHVFHIHDNQTGVEIVKNSRNSVETLIHFELQNLRPYTDYRVIVKAFTTKNEGEPSDQIAQRTDVGGPSAPAIVNLTCHSQESITIRWRRPYEFYNTIDFYIIKTRLAGQDTHRDIRINASAKELETAMILQNLTTNSYYEVKVAAATFSVINPKKIVLGKFSESRIIQLQPNCEKLQPLLRQSHNDYNLAVLVGIIFSCFGIILIIMAFFLWSRKCFHAAYYYLDDPPHHPNAPQVDWEVPVKIGDEIRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKNCTPYLEQQYKNIIQFQPKDIHIASAMKQVNSIKNRGAIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDINFAQFWPDEATPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPNSIYDFIVDVHERCNDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNILSFLPGNLNLLKRTALRTEFEDVTTATPDLYSKICSNGNVPQHVILQQQQLHMLQLQQQHLETQQQQQQQQQQQQQQQQTALNETVSTPSTDTNPSLLPILSLLPPTVAPLSSSSSTTPPTPSTPTPQPPQTIQLSSHSPSDLSHQISSTVANAASPVTPATASASAGATPTTPMTPTVPPTIPTIPSLASQNSLTLTNANFHTVTNNAADLMEHQQQQMLALMQQQTQLQQQYNTHPQQHHNNVGDLLMNNADNSPTASPTITNNNHITNNNVTSAAATDAQNLDIVG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 33 | N-linked_Glycosylation | CATALPTNSSNSPSS HHHHCCCCCCCCCCC | 41.31 | - | |
| 176 | N-linked_Glycosylation | YVPSKPQNLTILDVS CCCCCCCCCEEEEEE | 47.91 | - | |
| 212 | N-linked_Glycosylation | HVFHIHDNQTGVEIV EEEEEECCCCEEEEE | 27.44 | - | |
| 278 | N-linked_Glycosylation | PSAPAIVNLTCHSQE CCCCEEEEEEECCCC | 24.42 | - | |
| 322 | N-linked_Glycosylation | THRDIRINASAKELE CCCCHHCCCCHHHHH | 20.28 | - | |
| 336 | N-linked_Glycosylation | ETAMILQNLTTNSYY HHHHHHHCCCCCCCE | 35.59 | - | |
| 913 | Phosphorylation | IQSIQDDYELTVKML HHHCCCCCEEEEEEE | 22.56 | 27794539 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PTP99_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PTP99_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PTP99_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PTP69_DROME | Ptp69D | genetic | 8598046 | |
| PTP69_DROME | Ptp69D | genetic | 10648238 | |
| INSR_DROME | InR | physical | 21931847 | |
| PTP99_DROME | Ptp99A | physical | 23827685 | |
| ITBX_DROME | mys | physical | 21931847 | |
| ABL_DROME | Abl | physical | 21931847 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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