LAR_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LAR_DROME
• UniProt AC: P16621
• Protein Name: Tyrosine-protein phosphatase Lar
• Gene Name: Lar
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 2029
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Possible cell adhesion receptor (Probable). It possesses an intrinsic protein tyrosine phosphatase activity (PTPase). [PubMed: 2554325 It controls motor axon guidance]
• Protein Sequence: MGLQMTAARPIAALSLLVLSLLTWTHPTIVDAAHPPEIIRKPQNQGVRVGGVASFYCAARGDPPPSIVWRKNGKKVSGTQSRYTVLEQPGGISILRIEPVRAGRDDAPYECVAENGVGDAVSADATLTIYEGDKTPAGFPVITQGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVDMSNPRYSLKDGFLQIENSREEDQGKYECVAENSMGTEHSKATNLYVKVRRVPPTFSRPPETISEVMLGSNLNLSCIAVGSPMPHVKWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQIDSVSVVKVQSLPTAPTDVQISEVTATSVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISGIITMYYVVRALSPYTEYEFYVIAVNNIGRGPPSAPATCTTGETKMESAPRNVQVRTLSSSTMVITWEPPETPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTYANQAHHKRISNSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYVPGAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHGLGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDKSNLHKIPDQFLTDDLLPGRNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFDNYTN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
176	N-linked_Glycosylation	PNIYWIKNQTKVDMS CCEEEECCCCCCCCC	45.69	-
253	N-linked_Glycosylation	VMLGSNLNLSCIAVG HHCCCCCCEEEEEEC	33.87	-
298	N-linked_Glycosylation	INIQESANYTCIAAS HCCHHHCCCEEEEEC	41.76	-
553	N-linked_Glycosylation	VHYELYWNDTYANQA EEEEEEECCCCCCHH	20.42	-
597	Phosphorylation	SQRGEGATTPPIPVR CCCCCCCCCCCCCCC	51.17	22817900
605	Phosphorylation	TPPIPVRTKQYVPGA CCCCCCCCCCCCCCC	23.80	22817900
608	Phosphorylation	IPVRTKQYVPGAPPR CCCCCCCCCCCCCCC	15.35	22817900
616	N-linked_Glycosylation	VPGAPPRNITAIATS CCCCCCCCEEEEEEC	41.56	-
666	N-linked_Glycosylation	EATTMTLNMTSIVLD CCCEEEEECCHHHHH	23.63	-
721	N-linked_Glycosylation	DVKATPLNSTSIHVS CCCCCCCCCCEEEEE	44.43	-
774	N-linked_Glycosylation	VVDTLEFNVTGLQPD EEEEEEEEECCCCCC	22.52	-
915	N-linked_Glycosylation	TPGGPPSNITIRFQT CCCCCCCCEEEEEEC	40.99	-
962	N-linked_Glycosylation	HGLGSERNMTLRKAV CCCCCCCCHHHHHHH	24.60	-
1183	N-linked_Glycosylation	PFTTYNVNVSAIPSD CCCEEEEECEECCCC	20.56	-
1304	N-linked_Glycosylation	GSGDDYHNFTNRKLE CCCCCHHCCCCCCCH	38.93	-
1411	Phosphorylation	RRRQPCKTPDQAAVT CCCCCCCCCCHHHCC	38.52	22817900
1418	Phosphorylation	TPDQAAVTRPLMAAD CCCHHHCCCCEEHHH	23.11	22817900
1572	Phosphorylation	TATIVMMTRLEERTR HHEEEEEECCHHHCC	17.63	21402080

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LAR_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LAR_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LAR_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CADN_DROME	CadN	genetic	19766621
ENA_DROME	ena	genetic	11683993
SDC_DROME	Sdc	genetic	16213816
RAC1_DROME	Rac1	genetic	9425140
SYDE_DROME	RhoGAP100F	genetic	23238725
ITBX_DROME	mys	genetic	11553324
ABL_DROME	Abl	genetic	10069336
ENA_DROME	ena	physical	10069336
ENA_DROME	ena	physical	16476662
SDC_DROME	Sdc	physical	16476662
INSR_DROME	InR	physical	21931847
ITBX_DROME	mys	physical	21931847
ABL_DROME	Abl	physical	10069336
ABL_DROME	Abl	physical	21931847

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1572, AND MASSSPECTROMETRY.
PubMed: 18327897