SYDE_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYDE_DROME
• UniProt AC: Q9V9S7
• Protein Name: Rho GTPase-activating protein 100F
• Gene Name: RhoGAP100F
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1866
• Protein Description: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state..
• Protein Sequence: MQWKKKFTRLKAATGNSRVRRMLCCGRRKENGRSVPDVTASPGRAPPGPLPANQMPAMGNQQHHGNQQHHGNQQQHHGNQHSNHRGQSGSLSNAAGVKDPVMLQGDFRKVSGISSEIFRQIEAVENDHDPNTAAALEAVERRGEMIVRVLEPRCMGSKQAVDAAHKLMNKADARHTVQLVEIVKRPGQTLGLYIREGNGADRTDGVFISRIALESAVYNSGCLRVGDEILAVNLVDVTHMSLDDVVIIMSIPRRLVLAIRQRRGNRGTGSPGPPTLSRPEQKPPPVVVIKRDLRDEDLDETDRMPRPRSSRDRRTGDGREMTESRSRLGLGLNNYSPQSEQLDMYYNTRGGGGGAMGEPPNWGYKPPPPPSSVITEQPTKAHAFAPSHAYYQNAGTLESLAEKVHAFYPGQPGGPPVGPSRRMSTGTGNVGLAQQHARFPRSGSDQHLPRVEYSDYSNSLGRHSLLRSSLKPGTTGGAPMQVGVGGTLGRYGRYDQQRAGVSKYGPPSGGAQSLTRRSRPNLDYSSDTEATIGPRPSYYYYNRPAIGSMSRGSGGAGGGVGAASTAALLAGAADLNKFNSLPRERPGTRLQGIRSRMGDRLVDENDGNTSAPEFDVRRGRDLRQRITASPSIFTADEYRAWLRRAPSSSAIAEQMRMTRDMFAQPRAQRFSCSAENIHDALRNTESIYSSRNHILGTGTLDRNMGLTRPISALPVRSMSSQHIGGAGSIRSPSIRRMRQLLELSAGPASPSGSILSTGGHQSPAPTPSATLPRPHRQIDINPAEFAKYKLDKPIVDIGGISGMLWIHLLAGRGLRTAPEGAAGTATQGQTRDLYCVIECDRVHKARTVVRSGDLQFDWDESFELDLVGNKQLDVLVYSWDPQHRHKLCYRGAISLSSILRQSPLHQLALKVEPRGTIYIRMRHTDPLALYKRRGLPSLRAGYPTLFGADLETVVNRESKNAPGSAPVPIVLRRCVEEVERRGLDIIGLYRLCGSATKKRLLREAFERNSRAVELTPEHVPDINVITGVLKDYLRELPEPLFTRCLFQMTVDALAVCLPDDPEGNAKLMLSILDCLPRANRATLVFLLDHLSLVVSNSERNKMSAQALATVMGPPLMLHSASAQPGADIDHAQPIAVLKYLLQIWPQPQAQHQQMAQHMGGAAGAMMGGLVTAGSMSNMAGVASGRRGESTGQRGSKVSALPADRQQLLLQQQAQLMAAGNLLRSSTSVTNILSQGHPQLSATANNHLYQSVVGQLAQSHRALQQAVQQPYQLGGSVGSAIPDPSPLPLPGTPSPGSSSASTGSGSGSGKSTDTIKRGASPVSVKQVKIVDQPSSPYSIVMKKPPLQKDAPVEITTPTTQADTESTLGCKESNGTASRRGNVDFYDTHKTQAKSVVNEESSYSSKYTGSETKKIIPGNSSYTPSKANASGLSGGEDYKAMRNKSSATSSSSSSQATVLSAGSTATSAPTTSSDDSDDLVSYKSSASTNALLAQSQAMTTSQLMSKYLKREPRVQFTPIKSPESPSPPGSGDGLPKGTYQLVTPISGSSSKPGATTGAISKYTTGSVESSINANSQKLSSPSRLCNSKDSNSRTGTASSTTPATSMVSTGRRLFDSLASSSSSETETKTYIGGTTAASGAITTTIYTNDTKNSGSSSSKSGIGGGSGTGLGAVSGASSETRSFGSTLFGSSGLGNGNGSSHNHSSASPSPFTTTNGNGNHNTMHLYGTLPKNGTSTGAALFGGSANSSSYHSSASGSGAGTASSSGVSSMTGSTNSYDFYTSTSSTVSSSRPFANGGNNYHTLGTYRAQYAATNPFLDAFDEKPGSNGGNAHGEEKLGADKGHHRAAVMAFQSSGDSKNGSDEYDDIK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
719	Phosphorylation	ALPVRSMSSQHIGGA CCCCCCCCCCCCCCC	28.26	12537569
1311	Phosphorylation	GSGSGKSTDTIKRGA CCCCCCCCCCCCCCC	40.42	27794539
1319	Phosphorylation	DTIKRGASPVSVKQV CCCCCCCCCCCEEEE	28.76	27794539
1334	Phosphorylation	KIVDQPSSPYSIVMK EEECCCCCCCEEEEC	34.24	27794539
1522	Phosphorylation	TPIKSPESPSPPGSG CCCCCCCCCCCCCCC	33.78	27794539
1524	Phosphorylation	IKSPESPSPPGSGDG CCCCCCCCCCCCCCC	53.67	27794539
1578	Phosphorylation	ANSQKLSSPSRLCNS CCCCCCCCHHHHCCC	37.01	27794539
1724	Phosphorylation	NHNTMHLYGTLPKNG CCCEEEEEEECCCCC	8.06	18281928
1859	Phosphorylation	SGDSKNGSDEYDDIK CCCCCCCCCCCCCCC	36.34	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYDE_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYDE_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYDE_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-719, AND MASSSPECTROMETRY.
PubMed: 18327897