LA_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LA_DROME
• UniProt AC: P40796
• Protein Name: La protein homolog
• Gene Name: La
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 390
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcription termination by RNA polymerase III. Binds RNA and DNA. Binds to precursors of RNA polymerase III transcripts. May play a specialized role during fly development..
• Protein Sequence: MAEVAETPSVEAQEEVAQPAEAQVLEAKNGDAKKDPAPAAEEAAGGFTKQERAIIRQVEYYFGDANLNRDKFLREQIGKNEDGWVPLSVLVTFKRLASLSTDLSEIVAALNKSEEGLVEISEDKLSLRRHPERPIPEHNEERRKEIQERTAYAKGFPLDSQISELLDFAANYDKVVNLTMRKHYDKPTKSYKFKGSIFLTFETKDQAKAFLEQEKIVYKERELLRKWQVDYLKEKQEEYAQKNEKRKNKKEAKPEPAFELPKNAIVVFEGAPETSSREEIREAFEKIKDFEVAYIEFAKGETKGSVRLTEADAAEKYIAKVEEGKLKFKDEVSLSLRKATEEEEKEFIDKAIEFMKKRRDFTRNKGKRFNRKRHGGNDHKHGGGKKARGD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MAEVAETPSVEAQE -CCCCCCCCCHHHHH	15.89	19429919
9	Phosphorylation	AEVAETPSVEAQEEV CCCCCCCCHHHHHHH	39.75	19429919
49	Acetylation	EAAGGFTKQERAIIR HHCCCCCHHHHHHHH	48.15	21791702
233	Acetylation	KWQVDYLKEKQEEYA HHHHHHHHHHHHHHH	57.55	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LA_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEUR_DROME	neur	physical	14605208
RL13A_DROME	RpL13A	physical	14605208
CAPZB_DROME	cpb	physical	14605208
GALT1_DROME	GalNAc-T1	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-7 AND SER-9, AND MASSSPECTROMETRY.
PubMed: 17372656