dbPTM

RTEL1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RTEL1_DROME
UniProt AC	Q9W484
Protein Name	Regulator of telomere elongation helicase 1 homolog {ECO:0000255\|HAMAP-Rule:MF_03065}
Gene Name	CG4078
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	985
Subcellular Localization	Nucleus .
Protein Description	ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates..
Protein Sequence	MPESLIAGIPVHFPFEPYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQSEHQKQMVKMEKADFSGLGGGAPGGDLSELAKTMGRANNWGVPKVIYASRTHSQLTQAMRELKRTAYANMRSVVLGSRDQLCIHPEVMREQGNSNKTNMCKLRVHSKTCSFQMRVESRKDHPDLRGPTIMDIEDLVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPKARKANKIELGNTIVILDEAHNIEKICEESASVQIKSSDVAMAIEDVTHIMQVFASGESQDMAGDEPKDFTLDDLTLLKEMLLELEKAIDAIVVDNAVDGTTFPASMMYELLGKANFTYGNVATIVSLLDKLVQYLLVASQQMSIRKGGTFTLLSDLLTIVFANKEDVMSKVYASFKVHVLVEESKQGHGKQQGAKQQGGWLGKGTIAAATGLSKVAKIINFWCFNPGFGMEQLLNTQVRSVILTSGTLAPLKPLIAELAIPVAQHLENPHIVDQSQVYVKIIGTGPDRQQLISNYANRDNPKYISSLGQTILNVARIVPDGLLVFFPSYPMLNKCVDAWQASGLWADISCKKPIFLEPRSKDQFTSTMEEFYQAIRDSKGAVFMAVCRGKVSEGLDFADRNGRAVIITGLPFPPLKDPKVILKRRYLEANRTRENQLLSGQEWYNLDATRAVNQAIGRVIRHRNDYGAILLCDSRFKDASQVQQLSKWIRGHLGDRPQCSPFGPIVRELRQFFKNAEANMKLPDERETDSPLETVCKTEDEPLAAIPKVKREPGSNATFKSANESAIKVEMANSIKTWTPADYASAAGHKLGGAAPNAMDFMSRLDSNVSSIDFNCCTDSKSGSSGLVKIHKRERSSPTAPESSSQVTKKRYKLVENIKVEPSSSQAKEAPEERAAFLRELRSLVTQDQFRRFGKALLEYKNGTYESFQALMAILLDVLSAPKVRYMLVGMRKYLKNEHKDEFDRRVGNL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
712	Acetylation	LLCDSRFKDASQVQQ EEECCCCCCHHHHHH	51.80	21791702
765	Phosphorylation	PDERETDSPLETVCK CCCCCCCCCCCHHCC	38.51	22668510
872	Phosphorylation	IHKRERSSPTAPESS EEECCCCCCCCCCCC	32.27	21082442
874	Phosphorylation	KRERSSPTAPESSSQ ECCCCCCCCCCCCHH	57.71	17989248

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RTEL1_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RTEL1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RTEL1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ODR4_DROME	CG10616	physical	15575970
SINAL_DROME	sinah	physical	15575970
DFD_DROME	Dfd	physical	15575970

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RTEL1_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-874, AND MASSSPECTROMETRY.	18327897 [Abstract]