XPC_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: XPC_DROME
• UniProt AC: Q24595
• Protein Name: DNA repair protein complementing XP-C cells homolog
• Gene Name: Xpc {ECO:0000312|FlyBase:FBgn0004698}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1293
• Subcellular Localization: Nucleus .
• Protein Description: Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes (By similarity).; Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents..
• Protein Sequence: MSDEEEDSVSEGFSASEDEWKPSKDVKGGESSDDDDSDFDELQAEGGAAGSSGRSSAVAGKRGDHKAPSGIKGSSVKKRKPTGQSLRSKLYNKYRPPPKTFPTSPSQQKENTPRASGSKNAKTPNESGARNQHGPADSSSESSVEDYLVNPADLDLHSTFFAGGQKEKSPAPQFDCNAGITNLSDSGSEDNNESSFEDKAGNAFDFRGLLENANSLERTRDALSKRNVTATPPRSQAATMDVNALLALGENQNYQSVEVEEREGNQRKKAGRGAPAAPPTLDEPSRLSKTKSTRIKRHTKTRPVSTVVANAGDTDDSDFEEVADADLSSDQDDGETPNISGDLEIRVGLEGLRPTKEQKTQHELEMALKRRLNRDIKDRQILLHKVSLMCQIARSLKYNRLLSESDSLMQATLKLLPSRNAYPTERGTELKYLQSFVTWFKTSIKLLSPNLYSAQSPATKEAILEALLEQVKRKEARCKQDMIFIFIALARGMGMHCRLIVNLQPMPLRPAASDLIPIKLRPDDKNKSQTVESERESEDEKPKKDKKAGKPAEKESSKSTISKEAEKKNNAKKAEAKPLSKSTTKGSETTKSGTVPKVKKELSLSSKLVEKSKHQKAYTSSKSDTSFDEKPSTSSSSKCLKEEYSELGLSKKLLKPTLSSKLVLKSKNQSSFSSNKSDTSFEENPSTSSSSKSLKEETAKLSSSKLEDKKVASPAETKTKVQSSLLKRVTTQNISESGDSKKPKVAPVDTFSPVAGRTRRATVKPKTEEKPQVVGSPVIPKLMLSKVKQLNAKHSDTENASPANKHLQEQRNTRETRSRSKSPKVLISPSFLKKKSDGADSTSDPQKHQMAPETKARISPNFLSEALPARQLRSRGQKASSLAIPQLDGGDDVPLPKKRPKLEKLKNSQDSDEVFEPAKPVKKAPVLPKSVQNLRKDRRVMSTDDEGGSRLNRKTDASDMWVEVWSDVEEQWICIDLFKGKLHCVDTIRKNATPGLAYVFAFQDDQSLKDVTARYCASWSTTVRKARVEKAWLDETIAPYLGRRTKRDITEDDQLRRIHSDKPLPKSISEFKDHPLYVLERHLLKFQGLYPPDAPTLGFIRGEAVYSRDCVHLLHSREIWLKSARVVKLGEQPYKVVKARPKWDRLTRTVIKDQPLEIFGYWQTQEYEPPTAENGIVPRNAYGNVELFKDCMLPKKTVHLRLPGLMRICKKLNIDCANAVVGFDFHQGACHPMYDGFIVCEEFREVVTAAWEEDQQVQVLKEQEKYETRVYGNWKKLIKGLLIRERLKKKYNF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDEEEDSV ------CCHHHHHHH	66.10	27794539
31	Phosphorylation	KDVKGGESSDDDDSD CCCCCCCCCCCCCCC	42.20	19429919
32	Phosphorylation	DVKGGESSDDDDSDF CCCCCCCCCCCCCCH	40.53	19429919
37	Phosphorylation	ESSDDDDSDFDELQA CCCCCCCCCHHHHHH	47.36	19429919
104	Phosphorylation	PPKTFPTSPSQQKEN CCCCCCCCHHHCCCC	23.85	21082442
215	Phosphorylation	GLLENANSLERTRDA HHHHCHHHHHHHHHH	29.24	27626673
231	Phosphorylation	SKRNVTATPPRSQAA HHCCCCCCCCCHHHC	25.18	19060867
530	Phosphorylation	DDKNKSQTVESERES CCCCCCCCHHCHHHC	33.07	19429919
533	Phosphorylation	NKSQTVESERESEDE CCCCCHHCHHHCCCC	37.30	19429919
537	Phosphorylation	TVESERESEDEKPKK CHHCHHHCCCCCCCC	57.48	19429919
626	Phosphorylation	TSSKSDTSFDEKPST CCCCCCCCCCCCCCC	35.37	27794539
752	Phosphorylation	VAPVDTFSPVAGRTR CCCCCCCCCCCCCCC	22.13	28490779
776	Phosphorylation	EKPQVVGSPVIPKLM CCCCCCCCCHHHHHH	12.37	28490779
795	Phosphorylation	KQLNAKHSDTENASP HHHCHHCCCCCCCCH	45.59	21082442
801	Phosphorylation	HSDTENASPANKHLQ CCCCCCCCHHHHHHH	35.81	30478224
828	Phosphorylation	KSPKVLISPSFLKKK CCCCEEECHHHHCCC	15.44	19429919
830	Phosphorylation	PKVLISPSFLKKKSD CCEEECHHHHCCCCC	36.10	19429919
859	Phosphorylation	PETKARISPNFLSEA HHHHHCCCHHHHHHH	14.29	19429919
908	Phosphorylation	KLEKLKNSQDSDEVF HHHHHCCCCCCCCCC	33.50	25749252
911	Phosphorylation	KLKNSQDSDEVFEPA HHCCCCCCCCCCCCC	28.21	21082442
942	Phosphorylation	RKDRRVMSTDDEGGS HHCCCCCCCCCCCCC	26.31	19429919
943	Phosphorylation	KDRRVMSTDDEGGSR HCCCCCCCCCCCCCC	29.40	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of XPC_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of XPC_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of XPC_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RFC1_DROME	Gnf1	physical	22036573
OTP_DROME	otp	physical	25242320

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31; SER-32; SER-37;SER-533; SER-537; SER-908 AND SER-911, AND MASS SPECTROMETRY.
PubMed: 18327897