| UniProt ID | MOEH_DROME | |
|---|---|---|
| UniProt AC | P46150 | |
| Protein Name | Moesin/ezrin/radixin homolog 1 | |
| Gene Name | Moe | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 578 | |
| Subcellular Localization |
Cell junction, adherens junction . Cell membrane Peripheral membrane protein Cytoplasmic side . Cytoplasm, cytoskeleton . Cytoplasm . Nucleus, nucleoplasm . Chromosome . Nuclear localization is dependent on Nup98 and Rae1. Associated with the act |
|
| Protein Description | Involved in connections of major cytoskeletal structures to the plasma membrane. [PubMed: 8666669 Together with wgn, involved in control of axon targeting of R8 and R2-R5 photoreceptors, independent of egr] | |
| Protein Sequence | MSPKALNVRVTTMDAELEFAIQSTTTGKQLFDQVVKTIGLREVWFFGLQYTDSKGDSTWIKLYKKVMNQDVKKENPLQFRFRAKFYPEDVAEELIQDITLRLFYLQVKNAILTDEIYCPPETSVLLASYAVQARHGDHNKTTHTAGFLANDRLLPQRVIDQHKMSKDEWEQSIMTWWQEHRSMLREDAMMEYLKIAQDLEMYGVNYFEIRNKKGTDLWLGVDALGLNIYEQDDRLTPKIGFPWSEIRNISFSEKKFIIKPIDKKAPDFMFFAPRVRINKRILALCMGNHELYMRRRKPDTIDVQQMKAQAREEKNAKQQEREKLQLALAARERAEKKQQEYEDRLKQMQEDMERSQRDLLEAQDMIRRLEEQLKQLQAAKDELELRQKELQAMLQRLEEAKNMEAVEKLKLEEEIMAKQMEVQRIQDEVNAKDEETKRLQDEVEDARRKQVIAAEAAAALLAASTTPQHHHVAEDENENEEELTNGDAGGDVSRDLDTDEHIKDPIEDRRTLAERNERLHDQLKALKQDLAQSRDETKETANDKIHRENVRQGRDKYKTLREIRKGNTKRRVDQFENM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 61 | Acetylation | KGDSTWIKLYKKVMN CCCHHHHHHHHHHHC | 37.01 | 21791702 | |
| 140 | Acetylation | ARHGDHNKTTHTAGF HHCCCCCCCCCCCCH | 51.92 | 21791702 | |
| 254 | Acetylation | RNISFSEKKFIIKPI CCCCCCCCEEEEEEC | 52.35 | 21791702 | |
| 259 | Acetylation | SEKKFIIKPIDKKAP CCCEEEEEECCCCCC | 30.98 | 21791702 | |
| 300 | Phosphorylation | MRRRKPDTIDVQQMK HCCCCCCCCCHHHHH | 27.83 | 22817900 | |
| 380 | Acetylation | LKQLQAAKDELELRQ HHHHHHHHHHHHHHH | 55.54 | 21791702 | |
| 490 (in isoform 2) | Phosphorylation | - | 33.59 | 22668510 | |
| 498 | Phosphorylation | DVSRDLDTDEHIKDP CCCCCCCCCCCCCCH | 51.05 | 19429919 | |
| 511 | Phosphorylation | DPIEDRRTLAERNER CHHHHHHHHHHHHHH | 31.08 | 21082442 | |
| 524 | Acetylation | ERLHDQLKALKQDLA HHHHHHHHHHHHHHH | 46.14 | 21791702 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MOEH_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MOEH_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MOEH_DROME !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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