MOEH_DROME - dbPTM
MOEH_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MOEH_DROME
UniProt AC P46150
Protein Name Moesin/ezrin/radixin homolog 1
Gene Name Moe
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 578
Subcellular Localization Cell junction, adherens junction . Cell membrane
Peripheral membrane protein
Cytoplasmic side . Cytoplasm, cytoskeleton . Cytoplasm . Nucleus, nucleoplasm . Chromosome . Nuclear localization is dependent on Nup98 and Rae1. Associated with the act
Protein Description Involved in connections of major cytoskeletal structures to the plasma membrane. [PubMed: 8666669 Together with wgn, involved in control of axon targeting of R8 and R2-R5 photoreceptors, independent of egr]
Protein Sequence MSPKALNVRVTTMDAELEFAIQSTTTGKQLFDQVVKTIGLREVWFFGLQYTDSKGDSTWIKLYKKVMNQDVKKENPLQFRFRAKFYPEDVAEELIQDITLRLFYLQVKNAILTDEIYCPPETSVLLASYAVQARHGDHNKTTHTAGFLANDRLLPQRVIDQHKMSKDEWEQSIMTWWQEHRSMLREDAMMEYLKIAQDLEMYGVNYFEIRNKKGTDLWLGVDALGLNIYEQDDRLTPKIGFPWSEIRNISFSEKKFIIKPIDKKAPDFMFFAPRVRINKRILALCMGNHELYMRRRKPDTIDVQQMKAQAREEKNAKQQEREKLQLALAARERAEKKQQEYEDRLKQMQEDMERSQRDLLEAQDMIRRLEEQLKQLQAAKDELELRQKELQAMLQRLEEAKNMEAVEKLKLEEEIMAKQMEVQRIQDEVNAKDEETKRLQDEVEDARRKQVIAAEAAAALLAASTTPQHHHVAEDENENEEELTNGDAGGDVSRDLDTDEHIKDPIEDRRTLAERNERLHDQLKALKQDLAQSRDETKETANDKIHRENVRQGRDKYKTLREIRKGNTKRRVDQFENM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
61AcetylationKGDSTWIKLYKKVMN
CCCHHHHHHHHHHHC
37.0121791702
140AcetylationARHGDHNKTTHTAGF
HHCCCCCCCCCCCCH
51.9221791702
254AcetylationRNISFSEKKFIIKPI
CCCCCCCCEEEEEEC
52.3521791702
259AcetylationSEKKFIIKPIDKKAP
CCCEEEEEECCCCCC
30.9821791702
300PhosphorylationMRRRKPDTIDVQQMK
HCCCCCCCCCHHHHH
27.8322817900
380AcetylationLKQLQAAKDELELRQ
HHHHHHHHHHHHHHH
55.5421791702
490 (in isoform 2)Phosphorylation-33.5922668510
498PhosphorylationDVSRDLDTDEHIKDP
CCCCCCCCCCCCCCH
51.0519429919
511PhosphorylationDPIEDRRTLAERNER
CHHHHHHHHHHHHHH
31.0821082442
524AcetylationERLHDQLKALKQDLA
HHHHHHHHHHHHHHH
46.1421791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MOEH_DROME !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MOEH_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MOEH_DROME !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CRERF_DROMECG13624physical
15710747
MOEH_DROMEMoephysical
15710747
RS27A_DROMERpS27Aphysical
15710747
EXPA_DROMEexphysical
15710747
OTU_DROMEotuphysical
15710747
DOP1_DROMECG15099physical
15710747
SAYP_DROMEe(y)3physical
15710747
KRI1_DROMECG5645physical
15710747
CONT_DROMEContphysical
15710747
CAPZB_DROMEcpbphysical
15710747
FAT_DROMEftphysical
15710747
INSR_DROMEInRphysical
15710747
RLIP_DROMERlipphysical
15710747
RL22_DROMERpL22physical
15710747
SEM1A_DROMESema-1aphysical
15710747
TOP1_DROMETop1physical
15710747
ZFH1_DROMEzfh1physical
15710747
PDI_DROMEPdiphysical
22036573
HCD2_DROMEscuphysical
22036573
NLP_DROMENlpphysical
22036573
SH3BG_DROMESh3betaphysical
22036573
INO1_DROMEInosphysical
22036573
NACA_DROMENacalphaphysical
22036573
WDR1_DROMEflrphysical
22036573
TERA_DROMETER94physical
22036573
TRXR1_DROMETrxr-1physical
22036573
FAXC_DROMEfaxphysical
22036573
EF1D_DROMEeEF1deltaphysical
22036573
PGK_DROMEPgkphysical
22036573
IF5A_DROMEeIF-5Aphysical
22036573
FKB12_DROMEFK506-bp2physical
22036573
YC17_DROMECG16817physical
22036573
PSA6_DROMEProsalpha1physical
22036573
TALDO_DROMETalphysical
22036573
SMO_DROMEsmogenetic
16682173
RHO1_DROMERho1genetic
12511959
RHO1_DROMERho1genetic
16682173
RHO1_DROMERho1genetic
20404112
MYSN_DROMEzipgenetic
12511959
CRB_DROMEcrbphysical
12213838
PP1B_DROMEflwphysical
22133918

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MOEH_DROME

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Related Literatures of Post-Translational Modification

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