DOP1_DROME - dbPTM
DOP1_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DOP1_DROME
UniProt AC A1ZBE8
Protein Name Protein dopey-1 homolog
Gene Name CG15099
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 2599
Subcellular Localization
Protein Description May be involved in protein traffic between late Golgi and early endosomes..
Protein Sequence MESADALVEEQKLMAEAKYRTYMTNIDKALRNFEYSSEWADLISALGKLSKAISSNTQYQVIPRRLKIAKRLAQCMHPALPSGVHLKALETYSVIFSKTGPERLATEFIYSAGLFPLLGYAAMNVRPALLAIYETYFVPLGDKLRPALSGFLNGVLPGYDCGLDHFERISALLKQVCNAVNPMHFYTVLWESVANNAAIRLPAITYLLEHFNKRLDMQEQIYIMGHNREIMMSALCVCLNDSLILVQRNTLEFLLLGFPMHTVLLSEDDLVKLVTNGLNTILRRDMSLNRRLFSWLLGSEVAKNSPTYDTLSLDTSNAPLEEEPEPYFVKHSRHILIKALITTLRLSLECAPMDLKPYRIMLSLLDKAEIGSAVLDYVLHDIIRAMYISSGNAEALKSANLLFATFDPAYIWSYMTNMFEKACQQANSMQEKSQAGETSGKYACDVGSGDPCVLEICVLTEFLLETVSLEMYTETTRVYLPKVFLAITQLLSLHMDHISSNEITASLKLCMKIVSRVQPMITSPIKLNKLIEQSGGSSSDEKITMNSASDAGKTEAGAQGNSLEKSKSDSRLNQFAENTLHSADPNDEELIHRSASNQSVGRQSPNKKKAKSISRLSELDKDISASDTGQQSSSDLDTPRSIKKLKAKAKVPFIRSPKKQRPKDMVLIQSNTSAEVSDGPSAEEPKSAPPDQTPQFQLDEESRATQQRGFSILEKCIRQYEIFFEVYLSRKLLHIESEPKECSVKVQLQRTTSTIHTSNLFMAEQVLDHECPVRESQIERLFNLLRVDIVPRSKQLQRLLNRSLPLPASASELSSDSEAQEEKQQSLLIDGQTQRSVQQLAELQLSPSLRGAVKLAATLLVEMSTFPNCNKHVVLDKNEPELPNWLKVLCLVACFAQSDKELQVASITTLFDLISLLRSQIEHTTSPGVTFVVMLPLLKFGHVSYMEQHTRVFQLVSSILWDYLGTAGIDPAQIAALLHQLHSCLESGLVETVIGNRMQSQHLLQMQSQSRSDLGKAAIRNFQMERLAEAQLLCPTESTERLRESQARSFKKFELLWHLGRDKQTARGFEKTLLKVLDTLALPHYMSERTFVTNWLQASLLRGDLARLTKPLYKILLSASSKRVGIVHMQQLYRESETEVTPAFERDVYAISSEQGNVKYHHMETSSGNKKKSPIRNFPKKIFGVTLSGGKANKVSNFVSDKSTVATCSEATQDMNTIGLIINPLENANDFDDETDLEEPRIEIPHKETPLEQKLASAMDESEQPSQEQPANQPDNSLQYDQDITDHSDSSDFESDSELRETSIEKEDSITVSSSAGVSDDVKRFVGDCESVTDALTQHEKIKSRKTYRLTREKTPGENSLNSLEQKDHDSISELQADALPADEYFREDKKLGKRKKVLTSGEKKRLSCISKTSTDSNISGSHVEQPEQEEETEPGTESTINVEDKRRNLSLETSKLQPDMQKTLEKGKQNVEILRQNNAAAAAAAAAAAEEQISVRSSMKSTVSLTDAAHLYHNHLLIYLAIYDTRQTLYALQTLRNIICCDKRTFLCLSITTSFSSASLKQLLVRHRKSISGKGFDGSVGNSEYAQGYRGCMQLELLVTLCLFYARGYFQKESLDAQRQSPTLQDIVNNRRIQLESIELLTLICSELIEIVKGMGRGLANYIADLLARAKLQKVMLHCLNSSVCSYGLKGNTNSGSYAEQVLSFNDPQDDQLHADCFQLQLLRLLLAVIRLEHEVHQLRQDTPPAAGEDSAGNASPTRLAEGATANVKYLPNCLISQQPMFLAAVLGALQQERLRHLHRNWTDLVTSSLNCFSFGSLTNIVISVVHQLCSNLDRISKMGLPQQRHFPPDYVVSQLEALTILCHYCLLDNTQQTALSHLFNQAYPQTSSSAQSSSTGQLLNSIVHSFLSASESSTSAPAPRNPQLQAARNAVLSHLPRIMSSVAAIWDSELGQLRPVRQQLLEFLSPVSLHHGSNFLAAVAVTWQQRGIATNMNGLSIAEQFQRNSVLQACPAQLSLVSLVSSIRVMPMDSFVMTLHHVVRSPPPIHRPPAQLSIEVSALELFYFYMKSAPAPQLADAWSSLLALIRDGLNLTPPAQFALLMLLNEFVQRCPQMPFQDKKEVRELHDVTSRLVDSLSSVAGSCLEQTTWLRRNLAVKEDTDGLAKDNSVGGGGLQQYSLQAQSVLAAILSNLLDVAYGSQEKDKVVNIVTPLLYNITPYLKNHTARNVPFFYACSALLASLSGYQYTRKAWRKDMLDLLLDNAFFQMHLSCLPFWRMIMDSLMTYDNTTFRELMTRVSLSQAGSLNIFTSRDQEYEQRAMLLKRLAFVIYCSEFDQHNKYMPDIQEQLANSLRLVPMGPSVQAAVFLCFRVLLLRMSPDHVTSLWPIIIAEMVQVFLQMEQELKSESEERNQQLRLPSGIDVSWSAASGASNGYNSQTPMQHWRSVQLEACKLLELGCVLPATKLPHFQMYRWAFVGTEFDVHEEEVCLPNGSLENLATLPSALYVPHVRRVARLMDMKYTSQSPILQRPSNRHLMLHFQQLQSLQELYAFFTTLGISCPQPRNFADTENDVANCLKEIEEVLANDFLEKLPSITTPR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
534PhosphorylationLNKLIEQSGGSSSDE
HHHHHHHCCCCCCCC		32.1219429919
537PhosphorylationLIEQSGGSSSDEKIT
HHHHCCCCCCCCEEE		30.1419429919
538PhosphorylationIEQSGGSSSDEKITM
HHHCCCCCCCCEEEC		45.1219429919
539PhosphorylationEQSGGSSSDEKITMN
HHCCCCCCCCEEECC		52.0319429919
594PhosphorylationDEELIHRSASNQSVG
CHHHHHHHHCCCCCC		23.1427626673
599PhosphorylationHRSASNQSVGRQSPN
HHHHCCCCCCCCCCC		30.6922817900
604PhosphorylationNQSVGRQSPNKKKAK
CCCCCCCCCCHHHHH		29.1319429919
612PhosphorylationPNKKKAKSISRLSEL
CCHHHHHHHHHHHHH		30.5627794539
614PhosphorylationKKKAKSISRLSELDK
HHHHHHHHHHHHHCC		33.9719429919
617PhosphorylationAKSISRLSELDKDIS
HHHHHHHHHHCCCCC		34.7019429919
624PhosphorylationSELDKDISASDTGQQ
HHHCCCCCCCCCCCC		31.6719429919
626PhosphorylationLDKDISASDTGQQSS
HCCCCCCCCCCCCCC		28.9919429919
628PhosphorylationKDISASDTGQQSSSD
CCCCCCCCCCCCCCC		34.1019429919
632PhosphorylationASDTGQQSSSDLDTP
CCCCCCCCCCCCCCC		24.7522668510
633PhosphorylationSDTGQQSSSDLDTPR
CCCCCCCCCCCCCCH		24.4322668510
634PhosphorylationDTGQQSSSDLDTPRS
CCCCCCCCCCCCCHH		47.6519429919
638PhosphorylationQSSSDLDTPRSIKKL
CCCCCCCCCHHHHHH		28.0919429919
656PhosphorylationAKVPFIRSPKKQRPK
HCCCCCCCCCCCCCC		35.9319429919
687PhosphorylationPSAEEPKSAPPDQTP
CCCCCCCCCCCCCCC		57.6419429919
693PhosphorylationKSAPPDQTPQFQLDE
CCCCCCCCCCCCCCH		26.8319429919
751PhosphorylationVKVQLQRTTSTIHTS
EEEEEEECCCEEECC		16.4921082442
752PhosphorylationKVQLQRTTSTIHTSN
EEEEEECCCEEECCC		26.5121082442
753PhosphorylationVQLQRTTSTIHTSNL
EEEEECCCEEECCCE		25.4222817900
754PhosphorylationQLQRTTSTIHTSNLF
EEEECCCEEECCCEE		18.0621082442
809PhosphorylationRSLPLPASASELSSD
CCCCCCCCHHHHCCC		30.3219429919
811PhosphorylationLPLPASASELSSDSE
CCCCCCHHHHCCCHH		36.2519429919
814PhosphorylationPASASELSSDSEAQE
CCCHHHHCCCHHHHH		28.2219429919
815PhosphorylationASASELSSDSEAQEE
CCHHHHCCCHHHHHH		58.7519429919
817PhosphorylationASELSSDSEAQEEKQ
HHHHCCCHHHHHHHH		36.4619429919
1071AcetylationQTARGFEKTLLKVLD
HHHHHHHHHHHHHHH		42.0619608861
1173PhosphorylationSSGNKKKSPIRNFPK
CCCCCCCCCCCCCCC		34.1429892262
1186PhosphorylationPKKIFGVTLSGGKAN
CCCCEEEEECCCCCC		18.6529892262
1188PhosphorylationKIFGVTLSGGKANKV
CCEEEEECCCCCCCC		35.8121082442
1355PhosphorylationYRLTREKTPGENSLN
EECCCCCCCCCCCCC		31.6022817900
1360PhosphorylationEKTPGENSLNSLEQK
CCCCCCCCCCCHHHC		25.3219429919
1363PhosphorylationPGENSLNSLEQKDHD
CCCCCCCCHHHCCCC		38.2819429919
1371PhosphorylationLEQKDHDSISELQAD
HHHCCCCCHHHHHHH		25.2919429919
1373PhosphorylationQKDHDSISELQADAL
HCCCCCHHHHHHHCC		35.8819429919
1408PhosphorylationSGEKKRLSCISKTST
CCCHHHEEEEECCCC		17.2822817900
1413PhosphorylationRLSCISKTSTDSNIS
HEEEEECCCCCCCCC		30.0219429919
1414PhosphorylationLSCISKTSTDSNISG
EEEEECCCCCCCCCC		33.6719429919
1415PhosphorylationSCISKTSTDSNISGS
EEEECCCCCCCCCCC		48.9919429919
1417PhosphorylationISKTSTDSNISGSHV
EECCCCCCCCCCCCC		35.8319429919
1420PhosphorylationTSTDSNISGSHVEQP
CCCCCCCCCCCCCCC		38.1919429919
1422PhosphorylationTDSNISGSHVEQPEQ
CCCCCCCCCCCCCCC		19.9819429919
1451PhosphorylationEDKRRNLSLETSKLQ
HHHHHCCCHHHHCCC		27.9219429919
1757PhosphorylationEDSAGNASPTRLAEG
CCCCCCCCCCCCCCC		30.7019429919
1759PhosphorylationSAGNASPTRLAEGAT
CCCCCCCCCCCCCCC		35.5019429919
2525PhosphorylationDMKYTSQSPILQRPS
CCCCCCCCCCCCCCC		17.4219429919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DOP1_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DOP1_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DOP1_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DOP1_DROME !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DOP1_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-753; THR-1355; SER-1360;SER-1363; SER-1371 AND SER-2525, AND MASS SPECTROMETRY.

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