FKB12_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FKB12_DROME
• UniProt AC: P48375
• Protein Name: 12 kDa FK506-binding protein
• Gene Name: FK506-bp2
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 108
• Subcellular Localization: Cytoplasm .
• Protein Description: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Binds to ligand-free TGF beta type I receptor, from which it is released upon a ligand-induced, type II receptor mediated phosphorylation of the type I receptor. Binding is inhibitory to the signaling pathways of the TGF beta family ligands..
• Protein Sequence: MGVQVVPIAPGDGSTYPKNGQKVTVHYTGTLDDGTKFDSSRDRNKPFKFTIGKGEVIRGWDEGVAQLSVGQRAKLICSPDYAYGSRGHPGVIPPNSTLTFDVELLKVE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Acetylation	DSSRDRNKPFKFTIG CCCCCCCCCEEEEEC	53.37	21791702
48	Acetylation	RDRNKPFKFTIGKGE CCCCCCEEEEECCCC	50.56	21791702
53	Acetylation	PFKFTIGKGEVIRGW CEEEEECCCCEECCC	48.31	21791702
78	Phosphorylation	QRAKLICSPDYAYGS CCEEEEECCCCCCCC	17.51	25749252
81	Phosphorylation	KLICSPDYAYGSRGH EEEECCCCCCCCCCC	12.71	21082442
85	Phosphorylation	SPDYAYGSRGHPGVI CCCCCCCCCCCCCCC	23.55	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FKB12_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FKB12_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FKB12_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAN3_DROME	CG11486	physical	14605208
ENA_DROME	ena	physical	14605208
OR9A_DROME	Or9a	physical	14605208
TITIN_DROME	sls	physical	14605208
VINC_DROME	Vinc	physical	14605208
FLNA_DROME	cher	physical	14605208
CSW_DROME	csw	physical	14605208
CP312_DROME	Cyp312a1	physical	14605208
RL22_DROME	RpL22	physical	14605208
PSA4_DROME	Prosalpha3	physical	14605208
NLP_DROME	Nlp	physical	22036573
PDI_DROME	Pdi	physical	22036573
SH3BG_DROME	Sh3beta	physical	22036573
THIO2_DROME	Trx-2	physical	22036573
DOD_DROME	dod	physical	22036573
INO1_DROME	Inos	physical	22036573
CP2B_DROME	Capa	physical	22036573
HCD2_DROME	scu	physical	22036573
NACA_DROME	Nacalpha	physical	22036573
YC17_DROME	CG16817	physical	22036573
RS21_DROME	RpS21	physical	22036573
TCP4_DROME	Ssb-c31a	physical	22036573
BTHD_DROME	BthD	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.