PAN3_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAN3_DROME
• UniProt AC: Q95RR8
• Protein Name: PAN2-PAN3 deadenylation complex subunit PAN3 {ECO:0000255|HAMAP-Rule:MF_03181}
• Gene Name: PAN3 {ECO:0000255|HAMAP-Rule:MF_03181}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 790
• Subcellular Localization: Cytoplasm, P-body .
• Protein Description: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins..
• Protein Sequence: MCSTYGLLSFEFSDTAAMDPIFFSPTNGIPSESKLATYMNRQNVATPSGYGLNNGFSLLNLDSPLNKKSQVTPQSPEFIPTRLGSTPNFYAPYHNAPMQLSNGLNGVNGLTAAAAAAAAAAAAAAAAVPSSTSSASSASVTISKTANGGASMLALQKTASIASVTIAQQQPQHPQKQQQHPPSVGGGAVSAASAPIAISGAPPNPAAAPFVSSMSAQTPLKGRGAMMRQESPTAAMISGAGPGEKSPPHGMTPHGASPIPSALPTSVHQENVGGTIYFYPTANAQNSQPVVNSMVVDGTHPALHGVSAVAPMSAGVPAAMMYTGHVYPGPSSNVVTMQPKTLLESAFFMPDEMRAEVLARNEISNLIMDAAEAAQHALPLEVENYHALYPLEPPAQPLHAKLTFPATTYRATHNTTGYKYCLRRIHGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTTKAFGDNSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATIWSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISDITQFDPNASNPLALVNMHQQDDLTALGRLVLALACRCLQSVQRDNVQSSIDMVTRNYSTDLRNFIVYLFTTNNRRSVTDLMPMIGARFYTQLDALQSKIDMQEDELAKEMENGRLYRILVKLNSINERPDFNLDCTWSETGDRYMLKLFRDYLFHSVTEDGRPWLDHAHIVQCLNKLDAGSIERVQLMSRDEQSVLIVSYAELKNCLENAFSELMSSAAN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Phosphorylation	LNKKSQVTPQSPEFI CCCCCCCCCCCCCCC		22817900
75	Phosphorylation	KSQVTPQSPEFIPTR CCCCCCCCCCCCCCC		28490779
81	Phosphorylation	QSPEFIPTRLGSTPN CCCCCCCCCCCCCCC		22817900
160	Phosphorylation	LALQKTASIASVTIA EEEHHHHHHHEEEEH		21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAN3_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAN3_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAN3_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTH2_DROME	CG1307	physical	14605208
MOCS3_DROME	CG13090	physical	14605208
DOME_DROME	dome	physical	14605208
CH36_DROME	Cp36	physical	14605208
ER_DROME	e(r)	physical	14605208
Y678_DROME	CG2678	physical	14605208
SIR4_DROME	Sirt4	physical	14605208
CCNB_DROME	CycB	physical	14605208
DLL_DROME	Dll	physical	14605208
FD3_DROME	fd59A	physical	14605208
BAP60_DROME	Bap60	physical	14605208
MS57B_DROME	Mst57Db	physical	14605208
BUN1_DROME	bun	physical	14605208
BUN2_DROME	bun	physical	14605208
GBLP_DROME	Rack1	physical	14605208
SLCA_DROME	SclA	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.