dbPTM

RS21_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RS21_DROME
UniProt AC	O76927
Protein Name	40S ribosomal protein S21 {ECO:0000303\|PubMed:10022917, ECO:0000312\|EMBL:CAA08751.1}
Gene Name	RpS21
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	83
Subcellular Localization	Cytoplasm, cytosol . Cytoplasm . Rough endoplasmic reticulum . Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Protein Description	May be an associated component of the ribosome rather than a core structural subunit. May act as a translation initiation factor. Has a role in regulation of cell proliferation in the hematopoietic organs and the imaginal disks of larva..
Protein Sequence	MENDAGENVDLYVPRKCSASNRIIHAKDHASVQLSIVDVDPETGRQTDGSKTYAICGEIRRMGESDDCIVRLAKKDGIITKNF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
81	Acetylation	KKDGIITKNF----- HHCCCEECCC-----	46.04	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RS21_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RS21_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RS21_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIR2_DROME	Sir2	physical	14605208
THIO2_DROME	Trx-2	physical	22036573
HPF1_DROME	CG1218	physical	22036573
APLF_DROME	CG6171	physical	22036573
BTHD_DROME	BthD	physical	22036573
FTF1B_DROME	Hr39	physical	22036573
GMPPB_DROME	CG1129	physical	22036573
SH3BG_DROME	Sh3beta	physical	22036573
WDR82_DROME	Wdr82	physical	22036573
RSSA_DROME	sta	genetic	10022917
RSSA_DROME	sta	physical	10022917

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RS21_DROME

Related Literatures of Post-Translational Modification