APLF_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APLF_DROME
• UniProt AC: A8JR14
• Protein Name: Aprataxin and PNK-like factor
• Gene Name: CG6171
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 255
• Protein Description: Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro..
• Protein Sequence: MSATDASTADSGAKRKSSEDITHNCNANFGAENGLRKRVKSEEPVASIKDETNPEVPMKIKAEPVENADEPTSTTPAIKIKAEPADNGNSPAAAMVKTEPTNSNAQDAADESTVSSSSIRTSCRFGIRCYRRNPAHRSAEAHPGDQDYRRPNFPAPPLGTPACPFGNACYRRNPVHFQDYSHPADFNSAQNIRNRLRQRRAQRQNDDDSGTDEEDEPFGGDNDRDADYRPGADINEDEDDELEFDSQPISGDDYD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	DSGAKRKSSEDITHN CCCCCCCCHHHCCCC	42.89	19429919
18	Phosphorylation	SGAKRKSSEDITHNC CCCCCCCHHHCCCCC	42.18	19429919
22	Phosphorylation	RKSSEDITHNCNANF CCCHHHCCCCCCCCC	21.25	19429919
41	Phosphorylation	GLRKRVKSEEPVASI CHHHHCCCCCCCCCC	44.31	19429919
209	Phosphorylation	QRQNDDDSGTDEEDE HHHCCCCCCCCCCCC	51.06	19429919
211	Phosphorylation	QNDDDSGTDEEDEPF HCCCCCCCCCCCCCC	44.16	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of APLF_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APLF_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APLF_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HPF1_DROME	CG1218	physical	22036573
SLU7_DROME	Slu7	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.