SLU7_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SLU7_DROME
• UniProt AC: Q9VAQ7
• Protein Name: Pre-mRNA-splicing factor Slu7
• Gene Name: Slu7
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 574
• Subcellular Localization: Nucleus.
• Protein Description: Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron..
• Protein Sequence: MSSGPMRTPVSQIILSKHDQDAEEEPKKKSREDWRKAKELEEARKAGTAPAAVDEEGRDINPHIPQYISNAPWYYGSAGPTLKHQRPQHEDEQGQLDKRAPKGLNTARIITKFRKGACENCGAVTHKRKDCLERPRKVQAKYAESIVVHDEHLVNEAAVNYDEKRDRWSSYDPANHREIIEEYEKVEEAKRQLKAEKLKNDPDAEISDEEGNEDKYVDEVDMPGTKVDSKQRITVRNLRIREDTAKYLRNLDPNSAYYDPKTRSMRDNPNPAVPEEEAEFAGENFVRFSGDTTAQATAQLFAWEAHGKGVDVHLLAEPTKLELLQKEYEQKKEQFKSSTKTHIVEKYGGEEHLQVPPKSLLLAQTEEYIEYSRSGKVIKGVEKPKARSIYEEDVYINNHTTVWGSFWNAGRWGYKCCKSFIKNSYCVGMQEPEGYSEHHSTSSTAAATTEPAAQSQFKVPEVPPERPTSEVDSASSSEPSSSEEEEVKPEKKKTKKKSKKREKKKKAKEQRKQKGKNKETKDKDKTKEKDIPEELDDRKRAYNSMYDVKAPTEDEIEEWKKKRPRAEDPMLQFM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	GPMRTPVSQIILSKH CCCCCCHHHHHHCCC	19.50	21082442
207	Phosphorylation	NDPDAEISDEEGNED CCCCCCCCCCCCCCC	30.40	19429919
216	Phosphorylation	EEGNEDKYVDEVDMP CCCCCCCCCCEECCC	26.00	18327897
261	Acetylation	NSAYYDPKTRSMRDN CCCCCCCCCCCCCCC	54.39	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SLU7_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SLU7_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SLU7_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207 AND TYR-216, ANDMASS SPECTROMETRY.
PubMed: 18327897