dbPTM

HPF1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HPF1_DROME
UniProt AC	Q9VNI3
Protein Name	Histone PARylation factor 1-like {ECO:0000305}
Gene Name	CG1218
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	449
Subcellular Localization
Protein Description
Protein Sequence	MPKEDCKYWDKCYQQNPAHLSKYNHPKKQQEHEVDGAEGKKVAPKRSASSQSGEQKKEEQTEPVNKDKSNTSASSTEMVNKDTAKGSYEAETEELHKEAMSNISGKNYMEILEKRIRLSVQKEYDNLCESNEFIRHKFLVEMPPDFYEFWKFVGSLKIDPAKPKDAGLEHLDKVFQLQLVGPFEFLAGKFHGAKLGEPGDYLRHWRFYYDPPEFQTIFVRRGTGIHYGYWRDVPQDKENLLIARNDSAKGCQFQFVAGNAFDAFLYYLEHDFAATPFSCGQLAGTKKAVAKYLSDNSLELAQLDRLQRERNKRVVAKTFHRAGIVVPFDQKTEVGYRPLAVSDSELKKMLAMLERKDVDNGAAKQAVLEKLQPVANAANIAVDESDFGSALELGIDMFCSGHKELHMLASSLLVPAYSMLSRPQFIAIAKAHMEQRSREDNLSIFDVLK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
47	Phosphorylation	KKVAPKRSASSQSGE CCCCCCCCCCCCCCC	19429919
49	Phosphorylation	VAPKRSASSQSGEQK CCCCCCCCCCCCCCH	19429919
50	Phosphorylation	APKRSASSQSGEQKK CCCCCCCCCCCCCHH	19429919
52	Phosphorylation	KRSASSQSGEQKKEE CCCCCCCCCCCHHHH	19429919
72	Phosphorylation	NKDKSNTSASSTEMV CCCCCCCCCCCCCEE	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HPF1_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HPF1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HPF1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LACB2_DROME	CG12375	physical	14605208
THIO2_DROME	Trx-2	physical	22036573
SLU7_DROME	Slu7	physical	22036573
PARP1_HUMAN	PARP1	physical	27067600

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HPF1_DROME

Related Literatures of Post-Translational Modification