dbPTM

CONT_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CONT_DROME
UniProt AC	Q9VN14
Protein Name	Contactin
Gene Name	Cont
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1390
Subcellular Localization	Cell membrane Lipid-anchor, GPI-anchor . Cell junction, septate junction . Component of epithelial septate junctions. Nrx is required for its cell surface localization.
Protein Description	Required for organization of septate junctions and paracellular barrier functions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion..
Protein Sequence	MLAKIGLLASILVLNLVGQITPQFSENLPDPDPQSGQQPQNYQPSYNKDYSPRYNPLYTGQQSADPNQFDNTLVDGQSPNTYKGYYDGRAGGGGLGGNVVGPGNNLGGLGPQYDPFNRNSIGSAGVSYRDAYTDEDNFCPEHWVSFRQTCYRFIRSPKRNWAEAKKICKAHNADLINVDNVEKHSFILKNLILQNQRQNRFFISARQTGPLNWVNDDNTQLVQIEDSFSMDEQVPLENEDLHDNRFLVQNDLNNQNINNPNQFYNSLPGTVNQRNQNNLRGFIGPNQPYGDNRYVRDRVVYAFSKKRDRWMFMPAYEIELNLFICESKVLYSSDNVNIKLDDKRPYHYGLDINDMERIPRGPYFVKQPNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPLAQDRYTISGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNLKRSAETSEMNWGKSIFCDPPQHYPDVRYYWARDYFPNFVEEDQRVFVSRDGALYFSFIETVDRANYSCTVQTLVSDTGRNGPFFPLRVTPNSNYQALIFANTFPKVFPEAPVAGDEIRLECMAFGYPIPSYNWTRQGLPLQRNAYTINYGRVLIIQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQFTIPLKDMIKDYNSDVTFICEAFAIPDANYTWYKNAERLDPANINRDRYIIQDNVLTIKFLEKDKDDAMYQCGAQNQLKTSFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDGQVIGSGGHRRILPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHCEAAFDELLDIAYVWKHNGEVLKNNHDGTGRIIVDWNRLTVHNTSMRDAGDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAIRYYNILGRTNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYEDKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIEWASDEIKKQDHMGVAVVNIPLNNYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCFNVTWQPIDMSRENIRGKLIGHRLKYWKTTHQEEDSVYYLSRTTRNWALIVGLQPDTYYFVKVMAYNAAGEGPESERFEERTYRKAPQKPPSSVHVYGINPSTVRVVWRYVSPSQDEEPVEGYKVRIWESDQNMITANNTIVPIGQKLESYINNLTPGKSYNMRVLAYSNGGDGRMSSPTLHFQMGKTTRNGANTRHGHNINTALILSTLLLISTFLYTSQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
369	N-linked_Glycosylation	PYFVKQPNDTTFDVN CCCCCCCCCCEEECC	57.68	19349973
537	N-linked_Glycosylation	IETVDRANYSCTVQT EEECCCCCCEEEEEE	30.09	-
604	N-linked_Glycosylation	GYPIPSYNWTRQGLP CCCCCCCCCCCCCCC	37.67	-
618	Phosphorylation	PLQRNAYTINYGRVL CCCCCEEEEECCEEE	10.59	22668510
621	Phosphorylation	RNAYTINYGRVLIIQ CCEEEEECCEEEEEE	11.49	22668510
629	N-linked_Glycosylation	GRVLIIQNATTNDNG CEEEEEEECCCCCCC	28.92	-
631	Phosphorylation	VLIIQNATTNDNGEY EEEEEECCCCCCCCE	33.41	22668510
633	N-linked_Glycosylation	IIQNATTNDNGEYSC EEEECCCCCCCCEEE	36.07	19349973
638	Phosphorylation	TTNDNGEYSCTITNP CCCCCCCEEEEEECC	15.50	22668510
648	Phosphorylation	TITNPRKTLMKSIYI EEECCCCEEEEEEEE	33.11	22668510
691	N-linked_Glycosylation	AFAIPDANYTWYKNA ECCCCCCCCCEECCH	41.99	-
774	N-linked_Glycosylation	VYAVYNGNTTIVCDP EEEEECCCEEEEECC	30.34	-
912	N-linked_Glycosylation	WNRLTVHNTSMRDAG CCCEEECCCCCCCCC	29.52	17893096
986	N-linked_Glycosylation	ILGRTNWNRTWVNVS EECCCCCCCCEEEEC	33.31	-
991	N-linked_Glycosylation	NWNRTWVNVSTHVQA CCCCCEEEECHHHHH	17.37	-
1166	N-linked_Glycosylation	KPIALAYNSTCFNVT CCEEEEECCCEEEEE	25.82	-
1171	N-linked_Glycosylation	AYNSTCFNVTWQPID EECCCEEEEEEEECC	32.24	-
1307	N-linked_Glycosylation	DQNMITANNTIVPIG CCCEECCCCEEEECH	37.21	17893096
1362	GPI-anchor	GKTTRNGANTRHGHN CCCCCCCCCCCCCCC	20.12	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CONT_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CONT_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CONT_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NRG_DROME	Nrg	physical	15459097
NRG_DROME	Nrg	physical	16554482
NRX4_DROME	Nrx-IV	physical	15459097
NRX4_DROME	Nrx-IV	physical	16554482
NRX4_DROME	Nrx-IV	physical	22022470

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CONT_DROME

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."; Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.; Nat. Biotechnol. 27:378-386(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-369; ASN-633 AND ASN-912,AND MASS SPECTROMETRY.	19349973 [Abstract]
"Identification of N-glycosylated proteins from the central nervoussystem of Drosophila melanogaster."; Koles K., Lim J.-M., Aoki K., Porterfield M., Tiemeyer M., Wells L.,Panin V.; Glycobiology 17:1388-1403(2007). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-912 AND ASN-1307, AND MASSSPECTROMETRY.	17893096 [Abstract]