IF5A_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IF5A_DROME
• UniProt AC: Q9GU68
• Protein Name: Eukaryotic translation initiation factor 5A
• Gene Name: eEF5 {ECO:0000312|FlyBase:FBgn0285952}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 159
• Subcellular Localization: Cytoplasm.
• Protein Description: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis..
• Protein Sequence: MAELDDQFETTDSGASTTYPMQCSALRKNGFVMLKSRPCKIVEMSTSKTGKHGHAKVHMVGIDIFSNKKYEDICPSTHNMDVPNVKREDLQLIAISDDSFLTLMTESGDLREDLKVPEGELGEQLRLDFDSGKDLLCTVLKACGEECVIAIKTNTALDK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Acetylation	MQCSALRKNGFVMLK EECHHHHHCCEEEEE	63.37	21791702
35	Acetylation	KNGFVMLKSRPCKIV HCCEEEEECCCEEEE	26.73	21791702
45	Phosphorylation	PCKIVEMSTSKTGKH CEEEEEEECCCCCCC	18.94	19429919
46	Phosphorylation	CKIVEMSTSKTGKHG EEEEEEECCCCCCCC	32.69	19429919
47	Phosphorylation	KIVEMSTSKTGKHGH EEEEEECCCCCCCCC	22.40	19429919
48	Acetylation	IVEMSTSKTGKHGHA EEEEECCCCCCCCCE	62.48	21791702
51	Hypusine	MSTSKTGKHGHAKVH EECCCCCCCCCEEEE	52.20	-
51	Other	MSTSKTGKHGHAKVH EECCCCCCCCCEEEE	52.20	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IF5A_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IF5A_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IF5A_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTP61_DROME	Ptp61F	physical	14605208
SH3BG_DROME	Sh3beta	physical	22036573
NACA_DROME	Nacalpha	physical	22036573
DOHH_DROME	nero	genetic	19546244

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.