dbPTM

DOHH_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DOHH_DROME
UniProt AC	Q9V9U4
Protein Name	Deoxyhypusine hydroxylase {ECO:0000255\|HAMAP-Rule:MF_03101}
Gene Name	nero {ECO:0000255\|HAMAP-Rule:MF_03101}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	302
Subcellular Localization	Endoplasmic reticulum membrane Peripheral membrane protein Cytoplasmic side . In larval imaginal disk and Garland cells.
Protein Description	Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor (By similarity). Essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis. Has a role in eIF-5A-mediated translational control..
Protein Sequence	MVSQQQIEAIGGVLNNKERPLKERFRALFTLKNIGGGAAIEAISKAFDDDSALLKHELAYCLGQMQDAQALDILTKVLKDTTQEPMVRHEAAEAMGAIGHPDVLPILEEYKQDPVVEVAETCAIALDRVRWLQSGQKVDDSNPYASVDPSPPTAGDKSVTELKAIYLDAQQSLFDRYRAMFSLRNLRTEESVLAIAEGLKDSSALFRHEVAFVLGQLQEPCSIPFLQENLEDRLENEMVRHECAEALGAIATEDCIQILNRYAEDDKRVVKESCVIALDMCEYENSPEFQYADGLAKLDATK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
3	Phosphorylation	-----MVSQQQIEAI -----CCCHHHHHHH	22.45	29892262

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DOHH_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DOHH_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DOHH_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DOHH_DROME !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DOHH_DROME

Related Literatures of Post-Translational Modification