CRERF_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRERF_DROME
• UniProt AC: Q9VC61
• Protein Name: Protein CREBRF homolog {ECO:0000305}
• Gene Name: REPTOR {ECO:0000303|PubMed:25920570, ECO:0000312|FlyBase:FBgn0039209}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 755
• Subcellular Localization: Nucleus . Cytoplasm . Transolcation from the cytoplasm to the nucleus is promoted by dephosphorylation and inhibited by phosphorylation.
• Protein Description: Transcriptional regulator that acts in the TORC1 signaling pathway to regulate energy homeostasis and promote survival during nutrient deprivation. Upon TORC1 inhibition resulting from nutrient stress, it is recruited into the nucleus where along with RETPOR-BP it maintains energy homeostasis by regulating the expression of target stress response genes including those involved in glycogenesis and triglyceride biosynthesis. It also appears to negatively regulate some aspects of TORC1-dependent larval growth..
• Protein Sequence: MTENQLYPMSSEFFDTGSNSSSNTLKYDLYSLGSTVVGAALPTLTINTGYGSSSSNNNNTNNNNNNSSSHSSSSNCSTSTTNTCNVMLSTTAITIPRSSNHNQIHHHPYQQSDLQTPRHHPSPLHTLPSMTHQQNQLQQQQQQQHHNQQQQLQQSHLALGELSDFGLDALDAASLSPTLLQDVSLSAVSPLSTTLYNGNTSGAGSSNGIGSGSGGYFTPDMSHSLSLNVVSEQVLLQEATTPNELLYEMTPNSNAMWSDISSAIIHTKHEPFSLDDDYIFPNDKAEIQAADLSDLNGGDFLDVIGNIEDFLPQTAVTQSVNFLLSPQAQGQDALVAPPMELLQQQQQNHQQLQVGSLPQLQTLLTLSQQQQSNSSSTSPYEIYHSTPQKPQQQQLSASFSPGSQASQSPLTPPPPPHANRPQYQMVKSRNMQELIKKGFPMSSPPERSILSQSAALSPGGSSGFGSSASGNSTTTSNQTSGSAVRKSFGYQSAVENSQLSRLSSSAPTHLGLEHIWMRREPRQHLLSTGSLAEAESFSSLSTGSVLSPDGIDFSQDDEDDNSSENSDNYDDCSSDNGLSEDEDETRTSTPNHLSSSKGKERFFWQYNVQAKGPKGKRLVFQSKLEDPHVLNEVTDPVFSPTCSVRGIKVYKHSGKARKGDGNDLTPNARKLHNIGKELDKLSRTINDMTPVSELPFNVRPKSRKEKNKLASRACRLKKKAQHEANKIKLFGLEIEHSEFNVKAVEISYNPSIFVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
273	Phosphorylation	HTKHEPFSLDDDYIF CCCCCCCCCCCCCCC	41.42	19429919
442	Phosphorylation	IKKGFPMSSPPERSI HHCCCCCCCCCHHHH	39.67	25920570
443	Phosphorylation	KKGFPMSSPPERSIL HCCCCCCCCCHHHHH	37.92	19060867
487	Phosphorylation	SGSAVRKSFGYQSAV CCHHHHHHHCCCCHH	17.22	19429919
490	Phosphorylation	AVRKSFGYQSAVENS HHHHHHCCCCHHHCH	9.40	18511481
503	Phosphorylation	NSQLSRLSSSAPTHL CHHHHHHHCCCCCCC	22.57	19429919
504	Phosphorylation	SQLSRLSSSAPTHLG HHHHHHHCCCCCCCC	34.80	19429919
505	Phosphorylation	QLSRLSSSAPTHLGL HHHHHHCCCCCCCCC	34.59	19429919
508	Phosphorylation	RLSSSAPTHLGLEHI HHHCCCCCCCCCCCE	29.46	19429919
527	Phosphorylation	EPRQHLLSTGSLAEA CHHHHHHHCCCHHHH	36.76	25920570
530	Phosphorylation	QHLLSTGSLAEAESF HHHHHCCCHHHHHCC	25.21	25920570
589	Phosphorylation	EDETRTSTPNHLSSS CCCCCCCCCCCCCCC	27.74	19060867
595	Phosphorylation	STPNHLSSSKGKERF CCCCCCCCCCCCCEE	42.29	25920570
596	Phosphorylation	TPNHLSSSKGKERFF CCCCCCCCCCCCEEE	41.89	25920570
665	Phosphorylation	KGDGNDLTPNARKLH CCCCCCCCCCHHHHH	19.84	25920570
676	Acetylation	RKLHNIGKELDKLSR HHHHHHHHHHHHHHH	51.84	21791702
689	Phosphorylation	SRTINDMTPVSELPF HHHHCCCCCHHHCCC	24.33	19429919
692	Phosphorylation	INDMTPVSELPFNVR HCCCCCHHHCCCCCC	34.32	19429919
787 (in isoform 2)	Phosphorylation	-		22668510
788 (in isoform 2)	Phosphorylation	-		27626673

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
527	S	Phosphorylation	Kinase	TORC1	-	Uniprot
530	S	Phosphorylation	Kinase	TORC1	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRERF_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRERF_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FZO_DROME	fzo	physical	14605208
2AAA_DROME	Pp2A-29B	physical	25920570
1433Z_DROME	14-3-3zeta	physical	25920570
1433E_DROME	14-3-3epsilon	physical	25920570
PP11_DROME	Pp1alpha-96A	physical	25920570
TOR_DROME	Tor	physical	25920570
PP12_DROME	Pp1-87B	physical	25920570

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.