RLIP_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RLIP_DROME
• UniProt AC: Q9VDG2
• Protein Name: RalA-binding protein 1
• Gene Name: Rlip {ECO:0000312|EMBL:AAF55832.1}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 625
• Protein Description: Participates in receptor endocytosis during interphase, is also involved in mitotic processes when endocytosis is switched off..
• Protein Sequence: MDFDSPEEKEFPGLYASEAADAKSRKSKEESDFSEDHDHSKKDLLIGRRKDKKEKGKDRGYAALEGESSPEEELDTKSPSKSKKSKTFKFTSSKSKEKREKSRDKSEKDSKHAEEEPSVSHKVKEKERDKEKDRDEPKKKDKEEKRKEKDKKADKKDKKDKKSKQLSQQQDDVSAAEEVLALGYPVFGVSVSLATERSRCHDGVDIPLVVRDCIDFLQDHLKCEQIYKIEPIKTRLMHFKRLYNNREHDSAVDELNLPTACSLLKLFLRELPEPLLTTDLVARFEEVASHPKVTTQQAELQQLLEQLPKCNRTLLAWVLLHFDAVIQQERHNKLNAQSLAMLLSPTLQMSHRLMVALLCHCNNLFADVQLIKYVPPLTSTSPKLPDTPEDIQTELRKQDSLLSQIHSEMNAGFITKKREEQLWEVQRIITQLKRKLRTFEKKQEKTAEEVDNSSSAPPAVASEDTTDSKPAGTPAVSTNNSISQEEPKTDTLTPKDAPNDFTIDPSTGFILLPKSNPHRENLLRLQIEYDELMEWQNELKARIVAERNEVYRLKQLYEQQSINSQMASLASGSQAPPESDYERIIEHYTRENALLEHKKNMLGMELKEERRACIALQVELRLQQF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MDFDSPEEKEFP ---CCCCCHHHHCCC	33.92	27794539
27	Phosphorylation	ADAKSRKSKEESDFS HHHHHHCCHHHCCCC	44.16	19429919
31	Phosphorylation	SRKSKEESDFSEDHD HHCCHHHCCCCCCCC	45.08	19429919
34	Phosphorylation	SKEESDFSEDHDHSK CHHHCCCCCCCCCCH	47.29	19429919
40	Phosphorylation	FSEDHDHSKKDLLIG CCCCCCCCHHHHHHC	47.67	19429919
61	Phosphorylation	EKGKDRGYAALEGES HHCCCCCCHHHCCCC	6.92	19429919
68	Phosphorylation	YAALEGESSPEEELD CHHHCCCCCCHHHCC	63.15	19429919
69	Phosphorylation	AALEGESSPEEELDT HHHCCCCCCHHHCCC	31.84	21082442
76	Phosphorylation	SPEEELDTKSPSKSK CCHHHCCCCCCCCCC	46.15	19429919
78	Phosphorylation	EEELDTKSPSKSKKS HHHCCCCCCCCCCCC	36.18	19429919
80	Phosphorylation	ELDTKSPSKSKKSKT HCCCCCCCCCCCCCC	57.56	19429919
430	Phosphorylation	WEVQRIITQLKRKLR HHHHHHHHHHHHHHH	26.02	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RLIP_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RLIP_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RLIP_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RALA_DROME	Rala	physical	14605208
RL4_DROME	RpL4	physical	15710747
SIMA_DROME	sima	physical	15710747
CCNB_DROME	CycB	physical	12775724

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68 AND SER-69, AND MASSSPECTROMETRY.
PubMed: 18327897