SIMA_DROME - dbPTM
SIMA_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SIMA_DROME
UniProt AC Q24167
Protein Name Protein similar
Gene Name sima
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1507
Subcellular Localization Cytoplasm . Nucleus . Cytoplasmic in normoxia, nuclear translocation in response to hypoxia.
Protein Description Functions as a transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters..
Protein Sequence MVSLIDTIEAAAEKQKQSQAVVTNTSASSSSCSSSFSSSPPSSSVGSPSPGAPKTNLTASGKPKEKRRNNEKRKEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKDEPQQNSGVSTHHRDLFVRLKCTLTSRGRSINIKSASYKVIHITGHLVVNAKGERLLMAIGRPIPHPSNIEIPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGETSRYRFLGKYGGYCWILSQATIVYDKLKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQKEQHHQAAETEKEPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAEKTIEETKTIATIPPVTATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTASVLRPSPAPPLTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISSSNQQLQIAQQTQLQNPQQPAQDMSKGFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDINSLDSTTCSTTASGQHYQSPSSSSTSAPSNTSSSNNSYANSPLSPLTPNSTATASNPSHQQQQQHHNQQQQQQQQQQHHPQHHDNSNSSSNIDPLFNYREESNDTSCSQHLHSPSITSKSPEDSSLPSLCSPNSLTQEDDFSFEAFAMRAPYIPIDDDMPLLTETDLMWCPPEDLQTMVPKEIDAIQQQLQQLQQQHHQQYAGNTGYQQQQQQPQLQQQHFSNSLCSSPASTVSSLSPSPVQQHHQQQQAAVFTSDSSELAALLCGSGNGTLSILAGSGVTVAEECNERLQQHQQQQQQTSGNEFRTFQQLQQELQLQEEQQQRQQQQQQQQQQQQQQQLLSLNIECKKEKYDVQMGGSLCHPMEDAFENDYSKDSANLDCWDLIQMQVVDTEPVSPNAASPTPCKVSAIQLLQQQQQLQQQQQQQQNIILNAVPLITIQNNKELMQQQQQQQQQQQQEQLQQPAIKLLNGASIAPVNTKATIRLVESKPPTTTQSRMAKVNLVPQQQQHGNKRHLNSATGAGNPVESKRLKSGTLCLDVQSPQLLQQLIGKDPAQQQTQAAKRAGSERWQLSAESKQQKQQQQQSNSVLKNLLVSGRDDDDSEAMIIDEDNSLVQPIPLGKYGLPLHCHTSTSSVLRDYHNNPLISGTNFQLSPVFGGSDSSGGDGETGSVVSLDDSVPPGLTACDTDASSDSGIDENSLMDGASGSPRKRLSSTSNSTNQAESAPPALDVETPVTQKSVEEEFEGGGSGSNAPSRKTSISFLDSSNPLLHTPAMMDLVNDDYIMGEGGFEFSDNQLEQVLGWPEIA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
489PhosphorylationAKPLQLESEKAEKTI
CCCCCCCHHHHHHHH		53.6527794539
1041PhosphorylationQQQQQLLSLNIECKK
HHHHHHHHHCHHHCC		28.1422817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SIMA_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SIMA_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SIMA_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HNF4_DROMEHnf4physical
14605208
ARNT_DROMEtgophysical
9403694
DYL1_DROMEctpphysical
27626673
SQH_DROMEsqhphysical
27626673
RL7A_DROMERpL7Aphysical
27626673
RL17_DROMERpL17physical
27626673
RS6_DROMERpS6physical
27626673
HSP7C_DROMEHsc70-3physical
27626673
CLH_DROMEChcphysical
27626673
IF5_DROMEeIF5physical
27626673
HANG_DROMEhangphysical
27626673
BRX1_DROMECG11583physical
27626673
RS5A_DROMERpS5aphysical
27626673
RS10B_DROMERpS10bphysical
27626673
FLII_DROMEfliIphysical
27626673
PENG_DROMEpenphysical
27626673
RLA1_DROMERpLP1physical
27626673
RL15_DROMERpL15physical
27626673
RL27A_DROMERpL27Aphysical
27626673
EIF3I_DROMETrip1physical
27626673
PSDE_DROMERpn11physical
27626673
DX39B_DROMEHel25Ephysical
27626673
IF4A_DROMEeIF-4aphysical
27626673
GBLP_DROMERack1physical
27626673
RL13_DROMERpL13physical
27626673
CAND1_DROMECand1physical
27626673
CFA20_DROMECG5343physical
27626673
RL9_DROMERpL9physical
27626673
NFS1_DROMECG12264physical
27626673
EF2_DROMEEF2physical
27626673
RL31_DROMERpL31physical
27626673
1433Z_DROME14-3-3zetaphysical
27626673
RS11_DROMERpS11physical
27626673
ISWI_DROMEIswiphysical
27626673
EIF3M_DROMETango7physical
27626673
RS23_DROMERpS23physical
27626673
MLF_DROMEMlfphysical
27626673
RLA2_DROMERpLP2physical
27626673
PTRO_DROMEPatroninphysical
27626673
EIF3B_DROMEeIF3-S9physical
27626673
RL18A_DROMERpL18Aphysical
27626673
41_DROMEcoraphysical
27626673
CAPZA_DROMEcpaphysical
27626673
DCAF1_DROMEmahjphysical
27626673
RTF1_DROMERtf1physical
27626673
RS16_DROMERpS16physical
27626673
ATPA_DROMEblwphysical
27626673
RL23_DROMERpL23physical
27626673
FBRL_DROMEFibphysical
27626673
TBB3_DROMEbetaTub60Dphysical
27626673
MYSN_DROMEzipphysical
27626673
GALE_DROMEGalephysical
27626673
Y2199_DROMECG2199physical
27626673
PUF68_DROMEpUf68physical
27626673
SPTCA_DROMEalpha-Specphysical
27626673
RFC2_DROMERfC4physical
27626673
ROP_DROMERopphysical
27626673
RL18_DROMERpL18physical
27626673
ACADM_DROMECG12262physical
27626673
DBR1_DROMEldbrphysical
27626673
RL14_DROMERpL14physical
27626673
RS17_DROMERpS17physical
27626673
U520_DROMEl(3)72Abphysical
27626673
BRM_DROMEbrmphysical
27626673
EIF3A_DROMEeIF3-S10physical
27626673
GMPPB_DROMECG1129physical
27626673
RFC1_DROMEGnf1physical
27626673
CPR1_DROMECG12163physical
27626673
RL13A_DROMERpL13Aphysical
27626673
T2FA_DROMETfIIFalphaphysical
27626673
ARNT_DROMEtgophysical
9409674
RRP15_DROMECG3817physical
27626673
GYS_DROMEGlySphysical
27626673
CAF1_DROMECaf1physical
27626673
KPYK_DROMEPyKphysical
27626673
TCPA_DROMET-cp1physical
27626673
PRS4_DROMERpt2physical
27626673
SYEP_DROMEAats-gluprophysical
27626673
NCD_DROMEncdphysical
27626673
RS7_DROMERpS7physical
27626673
MODU_DROMEmodphysical
27626673
MA205_DROMEMap205physical
27626673
ATPB_DROMEATPsyn-betaphysical
27626673
RL10_DROMERpL10physical
27626673
RS15A_DROMERpS15Aaphysical
27626673
LOLA1_DROMElolaphysical
27626673
LOLA2_DROMElolaphysical
27626673
LOLA3_DROMElolaphysical
27626673
LOLA4_DROMElolaphysical
27626673
LOLA6_DROMElolaphysical
27626673
LOLA5_DROMElolaphysical
27626673
VATA2_DROMEVha68-2physical
27626673
NSUN2_DROMENsun2physical
27626673
COPB2_DROMEbetaCOPphysical
27626673
LDH_DROMEImpL3physical
27626673
TTF2_DROMEldsphysical
27626673
POE_DROMEpoephysical
27626673
ATC1_DROMECa-P60Aphysical
27626673
CWC15_DROMEc12.1physical
27626673
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SIMA_DROME

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Related Literatures of Post-Translational Modification

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