MLF_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MLF_DROME
• UniProt AC: Q9NKV0
• Protein Name: Myeloid leukemia factor
• Gene Name: Mlf
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 376
• Subcellular Localization: Cytoplasm .
• Protein Sequence: MSLFGALMGDFDDDLGLMNNHMNHTMNAMNMQMRSMNRLMNSFMPDPFMQVSPFDQGFQQNALMERPQMPAMPAMGLFGMPMMPNFNRLLNADIGGNSGASFCQSTVMTMSSGPDGRPQIYQASTSTKTGPGGVRETRRTVQDSRTGVKKMAIGHHIGERAHIIEKEQDMRSGQLEERQEFINLEEGEAEQFDREFTSRASRGAVQSRHHAGGMQAIMPARPAAHTSTLTIEPVEDDDDDDDDCVIQEQQPVRSSAGRHYSSAPTAPQNSGNIATAAAPTPTSSPTTYDTSNGNNNNYVSSRRSYLRNGHGHSLATPRRPLRTPPSSPLATVSTSPSIHPHPYAANPRRQQRAVKHFHTEDEAASSYKAVKRGKKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
166	Acetylation	ERAHIIEKEQDMRSG HHHEEHHHHHHHHCC	50.71	21791702
260	Phosphorylation	RSSAGRHYSSAPTAP CCCCCCCCCCCCCCC	11.71	19060867
260 (in isoform 2)	Phosphorylation	-	11.71	21082442
280	Phosphorylation	IATAAAPTPTSSPTT CCEECCCCCCCCCCC	34.18	22817900
323	Phosphorylation	TPRRPLRTPPSSPLA CCCCCCCCCCCCCCC	47.43	19429919
326	Phosphorylation	RPLRTPPSSPLATVS CCCCCCCCCCCCEEE	45.88	19429919
327	Phosphorylation	PLRTPPSSPLATVST CCCCCCCCCCCEEEC	29.70	19429919
331	Phosphorylation	PPSSPLATVSTSPSI CCCCCCCEEECCCCC	23.75	19429919
333	Phosphorylation	SSPLATVSTSPSIHP CCCCCEEECCCCCCC	20.86	19429919
334	Phosphorylation	SPLATVSTSPSIHPH CCCCEEECCCCCCCC	40.08	19429919
335	Phosphorylation	PLATVSTSPSIHPHP CCCEEECCCCCCCCC	14.78	19429919
337	Phosphorylation	ATVSTSPSIHPHPYA CEEECCCCCCCCCCC	33.04	19429919
343	Phosphorylation	PSIHPHPYAANPRRQ CCCCCCCCCCCHHHH	18.47	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MLF_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MLF_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MLF_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DNAJ1_DROME	DnaJ-1	physical	15710747
PRD_DROME	prd	physical	15710747
LOZEN_DROME	lz	genetic	22411814

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-323, AND MASSSPECTROMETRY.
PubMed: 18327897