dbPTM

DNAJ1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DNAJ1_DROME
UniProt AC	Q24133
Protein Name	DnaJ protein homolog 1
Gene Name	DnaJ-1
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	334
Subcellular Localization	Cytoplasm.
Protein Description
Protein Sequence	MGKDFYKILGLERKASDDEIKKAYRKLALKYHPDKNKSPQAEERFKEIAEAYEVLSDKKKRDIFDNYGEDGLKGGQPGPDGGGQPGAYTYQFHGDPRATFAQFFGSSDPFGAFFTGGDNMFSGGQGGNTNEIFWNIGGDDMFAFNAQAPSRKRQQDPPIEHDLFVSLEEVDKGCIKKMKISRMATGSNGPYKEEKVLRITVKPGWKAGTKITFPQEGDSAPNKTPADIVFIIRDKPHSLFKREGIDLKYTAQISLKQALCGALVSVPTLQGSRIQVNPNHEIIKPTTTRRINGLGLPVPKEPSRRGDLIVSFDIKFPDTLAPSLQNQLSELLPN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	LGLERKASDDEIKKA HCCHHCCCHHHHHHH	48.94	19429919
30	Acetylation	AYRKLALKYHPDKNK HHHHHHHHHCCCCCC	35.59	19608861
38	Phosphorylation	YHPDKNKSPQAEERF HCCCCCCCHHHHHHH	31.47	22817900
187	Phosphorylation	ISRMATGSNGPYKEE HCEECCCCCCCCCCE	33.97	18327897

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DNAJ1_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DNAJ1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DNAJ1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERF1_DROME	eRF1	physical	14605208
OAZ_DROME	Oda	physical	14605208
ANLN_DROME	scra	physical	14605208
MED10_DROME	MED10	physical	14605208
ARCH_DROME	CG6353	physical	14605208
MLF_DROME	Mlf	physical	14605208
SAP47_DROME	Sap47	physical	14605208
PGPLE_DROME	PGRP-LE	physical	22036573
HSP83_DROME	Hsp83	genetic	24091676

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DNAJ1_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187, AND MASSSPECTROMETRY.	18327897 [Abstract]