ERF1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ERF1_DROME
• UniProt AC: Q9VPH7
• Protein Name: Eukaryotic peptide chain release factor subunit 1
• Gene Name: eRF1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 438
• Subcellular Localization: Cytoplasm.
• Protein Description: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA..
• Protein Sequence: MSGEETSADRNVEIWKIKKLIKSLEMARGNGTSMISLIIPPKDQISRVSKMLADEFGTASNIKSRVNRLSVLGAITSVQHRLKLYTKVPPNGLVIYCGTIVTEEGKEKKVNIDFEPFKPINTSLYLCDNKFHTEALTALLADDNKFGFIVMDGNGALFGTLQGNTREVLHKFTVDLPKKHGRGGQSALRFARLRMEKRHNYVRKVAEVATQLFITNDKPNIAGLILAGSADFKTELSQSDMFDPRLQSKVIKLVDVSYGGENGFNQAIELAAESLQNVKFIQEKKLIGRYFDEISQDTGKYCFGVEDTLRALELGSVETLICWENLDIQRYVLKNHANSTSTTVLHLTPEQEKDKSHFTDKESGVEMELIESQPLLEWLANNYKMFGATLEIITDKSQEGSQFVRGFGGIGGILRYKVDFQSMQLDELDNDGFDLDDY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Phosphorylation	KSRVNRLSVLGAITS HHHHHHHHHHHHHHC	16.44	21082442
339	Phosphorylation	VLKNHANSTSTTVLH HHHHCCCCCCEEEEE	25.23	19429919
340	Phosphorylation	LKNHANSTSTTVLHL HHHCCCCCCEEEEEC	29.87	19429919
341	Phosphorylation	KNHANSTSTTVLHLT HHCCCCCCEEEEECC	23.15	19429919
342	Phosphorylation	NHANSTSTTVLHLTP HCCCCCCEEEEECCH	22.47	19429919
343	Phosphorylation	HANSTSTTVLHLTPE CCCCCCEEEEECCHH	22.34	22668510

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ERF1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ERF1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ERF1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SAP47_DROME	Sap47	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-341, AND MASSSPECTROMETRY.
PubMed: 18327897