HNF4_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HNF4_DROME
• UniProt AC: P49866
• Protein Name: Transcription factor HNF-4 homolog
• Gene Name: Hnf4
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 704
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptionally controlled transcription factor. Important for the differentiation of various specialized cell types that arise from both endoderm and mesoderm. May have a role in early gut formation. Plays an essential role in lipid catabolism, regulating lipid mobilization and beta-oxidation in response to nutrient deprivation..
• Protein Sequence: MMKHPQDLSVTDDQQLMKVNKVEKMEQELHDPESESHIMHADALASAYPAASQPHSPIGLALSPNGGGLGLSNSSNQSSENFALCNGNGNAGSAGGGSASSGSNNNNSMFSPNNNLSGSGSGTNSSQQQLQQQQQQQSPTVCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRISCRRTSNDDPDPGNGLSVISLVKAENESRQSKAGAAMEPNINEDLSNKQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSMHLKDVLLLSNNCVITRHCPDPLVSPNLDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESRGRFGEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEMLLGGELADNPLPLSPPNQSNDYQSPTHTGNMEGGNQVNSSLDSLATSGGPGSHSLDLEVQHIQALIEANSADDSFRAYAASTAAAAAAAVSSSSSAPASVAPASISPPLNSPKSQHQHQQHATHQQQQESSYLDMPVKHYNGSRSGPLPTQHSPQRMHPYQRAVASPVEVSSGGGGLGLRNPADITLNEYNRSEGSSAEELLRRTPLKIRAPEMLTAPAGYGTEPCRMTLKQEPETGY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MMKHPQDLSV -----CCCCCCCCCC	11.50	21791702
3	Acetylation	-----MMKHPQDLSV -----CCCCCCCCCC	11.50	-
224	Phosphorylation	DRISCRRTSNDDPDP HHHCCCCCCCCCCCC	57.44	19429919
225	Phosphorylation	RISCRRTSNDDPDPG HHCCCCCCCCCCCCC	51.41	19429919
616	Phosphorylation	SRSGPLPTQHSPQRM CCCCCCCCCCCCCCC	40.85	19429919
619	Phosphorylation	GPLPTQHSPQRMHPY CCCCCCCCCCCCCCC	34.52	19429919
632	Phosphorylation	PYQRAVASPVEVSSG CCCCCCCCCEEECCC	40.44	19429919
671	Phosphorylation	AEELLRRTPLKIRAP HHHHHHCCCCCCCCC		22817900
682	Phosphorylation	IRAPEMLTAPAGYGT CCCCHHHCCCCCCCC		22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HNF4_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HNF4_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HNF4_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIR2_DROME	Sir2	physical	27058248

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.