CAND1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAND1_DROME
• UniProt AC: Q9VKY2
• Protein Name: Cullin-associated NEDD8-dissociated protein 1
• Gene Name: Cand1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1248
• Protein Description: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes (Probable)..
• Protein Sequence: MASHQYHQIANLLEKMTSTDKDFRFMATNDLMTELQKDSIILDDESEKKVVRMVLKLLEDKNGEVQNLAVKCLGPLVNKVKEIQVETIVDSLCANMMSNTEQLRDISSIGLKTVIAELPQSSNSLAPNVCQRITGKLSTAIEKEDVSVKLESLDILADLLSRFGEFLVPFHSTILKALMPQLASSRQAVRKRTIVALSFLLIQANSNAYNGVIDHLLDGLENPPNPAAIRTYIQCLASICRQAGHRLCNHIDRSMLLLSQYSQRDDDELREFCLQACEAFVMRCPDAINPHIPMILELCLNYITYDPNYNYETDDGDTGNAMDTEDDEYVDSEEYSDDDDMSWKVRRAAAKCLEVLISTRQELVEDFYRSLSPALIARFKEREENVKSDIFHAYVALLKNTRLTDDVANDHDSMDQVSGPTSLLIEQLPLIVKAIQPLMREKSMKTRQDCFLLLRELLNSLPGALGPYLDSIVPGISYSLNDKSSTSNMKIESLGFLYSLLQGHPPHVFHPHIPLLVPLVVTSVFDPFYKIATEALLVLQQLVKVIRPLEPNAAKSDFDAPSFVGQVYSCTLQKLKVTDVDQEVKERAIACMGQIIANMGDMLQNELAVCLPIFMERLKNEVTRLSSVKALTLIAASSLRIDLTPILHDVLPALGTFLRKNHRALKLHSLDLINKIVINYSSNFEANLLQTAIVEIPPLISDSDLHVAQYSLTLLSTVARRQPQALVGIHEQFLRSVLILVRSPLLQGSALNCTLELFQALVQTQLSGLDYHSLVSKLMAPVLGGNGDVKSRATAGAPSEVVQLHKQAYHSSAKCIAALTQQCPQVATPLATKLITDLQKRNDTEIIFCLLTIGEIGRHFDLSSIQVLPQTIIECFGATSEDVKAAASHALGAVSVGSLQTYLPLILHEIEVQPKRQYLLLHSLKEVISSLSVSPSGLAQLLPSVPSIWDQLFKHCECSEEGSRNVVAECLGKLVLVNPDELLPQLQQALRSESATMRTVVVSSVKFTISDQPQPIDVLLKQNIGEFLFALRDPEPQVRRVALVAFNSAVHNKPSLVRDLLPTLLPWLYSETKVKSELIREVEMGPFKHTVDDGLDIRKAAFECMYTLLEQGLDRVDVMQFLDHVQAGLCDHYDIKMLTYLMTARLAILCPDKVLLRLDQFIQQLRDTCTHKVKANSVKQEYEKQDELKRSALRAVSALSQIPKANKNQQLVDFLKSIKETPELNKIFEYIQKDSITGSSDIIVMDQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
87	Phosphorylation	VKEIQVETIVDSLCA CHHCCHHHHHHHHHH		22817900
98	Phosphorylation	SLCANMMSNTEQLRD HHHHHHCCCHHHHHH		22817900
1204	Acetylation	SALSQIPKANKNQQL HHHHCCCCCCCCHHH		21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAND1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAND1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAND1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OSTC_DROME	CG9662	physical	22036573
KRH2_DROME	Kr-h2	physical	22036573
CUL1_DROME	Cul1	physical	20691177
RDX_DROME	rdx	physical	20691177

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.