DCAF1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCAF1_DROME
• UniProt AC: Q9W2F2
• Protein Name: Protein mahjong
• Gene Name: mahj
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1544
• Subcellular Localization: Nucleus.
• Protein Description: Probable substrate recognition component of tsome E3 ubiquitin-protein ligase complex (By similarity). Plays a key role in cell competition via its interaction with l(2)gl..
• Protein Sequence: MSEGSGSENAAAAEAAAEAEAATEAALMAEAVAVAYQSDEEEQPEAEDMPEQAGDNQEEDAAEQQDGGEPEADEDADADDAMSVENAENESDSGGNAEETAAADRRQATKKELTQIIDKWEQQQTQNGYDPVPTLRSLAEIFEREKDVYRRKDPDPLDSRHPYRADPSCQYGLLLKLLFRKDTFMGKLLNDYLRENYFSRQNVSRSSLELNILACRLILEIMPGMETSAVFQTAEGDGTINRIYSWAEDSIEPLQSYATGLLAEAMEVSDIAINFRDLNIRLVPKMIKRLHMLLAISKSATSDVNTSMHNLSADSSTAGMLSWVACASNASAPQSPQHNGSGLGASSSQHGDASNMSILFENSRDAFSVSRYYKRMYIPLHPATADTSQMLIMRFLTSLGEYQEFLAMAFENNVMQLIFGYLENLDRRDTCLAYEVLKYLASLLCHKKFALEFISHGGLELLLKVPRPSLATTGVSIAIYYLAYCEDAMERICSMQRPLISELVRYALWILGRCHDSSKCHATMFFSLSFQFKVILDEFDAQDGLRKLYNVISVLKILDPSHNDSDNDSDFNEDVECASRQMVRHVCVALKRYMEAHFFYKYNSFLCQTNAASPAPSSAHYFNQNPTVAAKLTFDQLNDQIRTLQEHTSIRAHWQPVDQLMKLGGITMLLRIIAFSYDWVNSGRSETVRSALDVLSVCCIIPRVYVVLCERLLMLDKTTTSGFCSVLGAAAGEISSDAEVIKSALAVLCHCVCSPIIRKDSGTSLIKFGTSSRKNKANHKYAEELIERVWESVCSNNGIVVLLSLMQTKGPITDADCIRGMACRALAGLARSDRVRQIVSKLPLFASGQLQTLMRDPILQEKRAEHVIFQKYALELLERVSGKTKPLNNPLDPSLSNMHKANVIAQTRIQYNKQQLYQLIFEHLESNGLSQTAQMLQREVGLPLQTPTTRSFHQSPFDYKSLPSGSSSLSRNRLRSRMQDVNAAIMGNGDLNRSFGEDSSPAGAGGSNAGDGVSIPNFSSLNTTQTPIKIRRTDRSSVSRSIQKQAMEPGGMSVGLAEDGQLHPKRITLNTIVTEYLTNQHSLCNNPVTTCPQFDLYEPHKCPDPKPSRLLSSNYNLTSRHARTQAGFNTSRFDRRYVHTHFSPWRSIRSADYEDLEFTCCDLAGKYIIVGTQQGDGRVFNMNDGVEQFFSNCHNFSVDAIKANRAGDLVITSSFWRTPTSILWSIADDEFKLKLRLPDVTYCEFSQTVQDRLLGTQNECATLFDINTGSKVASFTPTIPNLYTKNRATLCRTDELILSDGVLWDVRSGKEIHKFDKFNQCISGVFHPNCLEIIANTEVWDLRTFHLLQTVPVLDQRNCTFSPMHVIYGASLGADRDHDMETTTYDTSFNVLDAYDYSSIATIDVKRNINDLSVSANGSLIAVVEDYSGYESKQETYVKIYAVGVKKSERSEEEDDEEVPESDEDGSDTGSENTFAIGQNLLGFPLLRNLHGSDNDDEDLDEDDDDGEPLDSDDDSDDDDGSDNGDDDGDFDVLEYFDRSSSDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
368	Phosphorylation	ENSRDAFSVSRYYKR ECCCCCHHHHHHHHH	22.39	19429919
561	Phosphorylation	VLKILDPSHNDSDND HHHHCCCCCCCCCCC	34.29	19429919
565	Phosphorylation	LDPSHNDSDNDSDFN CCCCCCCCCCCCCCC	43.56	19429919
569	Phosphorylation	HNDSDNDSDFNEDVE CCCCCCCCCCCHHHH	50.81	19429919
613	Phosphorylation	LCQTNAASPAPSSAH CCCCCCCCCCCCCCC	21.13	21082442
770	Phosphorylation	TSLIKFGTSSRKNKA CCEEEECCCCCCCCC	27.02	22817900
946	Phosphorylation	EVGLPLQTPTTRSFH HHCCCCCCCCCCCCC	30.22	28490779
955	Phosphorylation	TTRSFHQSPFDYKSL CCCCCCCCCCCCCCC	20.97	22817900
994	Phosphorylation	GNGDLNRSFGEDSSP CCCCCCCCCCCCCCC	36.21	21082442
1000	Phosphorylation	RSFGEDSSPAGAGGS CCCCCCCCCCCCCCC	30.96	21082442
1026	Phosphorylation	SSLNTTQTPIKIRRT CCCCCCCCCEEEEEC	25.53	30478224

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCAF1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCAF1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCAF1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-565; SER-569 ANDSER-955, AND MASS SPECTROMETRY.
PubMed: 18327897