dbPTM

NSUN2_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NSUN2_DROME
UniProt AC	Q9W4M9
Protein Name	tRNA (cytosine(34)-C(5))-methyltransferase
Gene Name	Nsun2
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	746
Subcellular Localization	Nucleus, nucleolus.
Protein Description	RNA methyltransferase that methylates tRNAs. Methylates cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Required for short-term memory..
Protein Sequence	MGRNQKQNFFAARKRQKRENGPKRTDRQAQPYEEIKRDNAFFIKYYQLQKICATDEEWTQFLASIRDNLPTTFRVTGFKDEAKALLSIIETQLFTEYVRAVAELHQKAPEDVERPLCLPWYPNGLAYQLHLTRKDIRRSEPLYRLHNFLIVETTAGGISRQEAVSMIPPIVLDVRPTDKVLDMCAAPGSKTAQLIEALHAAPEEHKIPPGFVLANDVDNNRCYMLVHQAKRLNSPCLLVTNHDSSVFPNLVTTKPDGSKAILKFDKILCDVPCSGDGTLRKNPDIWLKWNLAQAYNLHGIQYRIVRRGAEMLEVGGRLVYSTCSLNPIENEAVLQRIIKDADGALELVDAGHLVPGLKYKPGMTDWKLATKEVDQIFTRFEEVPESLHTIIRPGMFPLPADEMAKIGLEKCLRVLPHLQDSGGFFVAVLEKRRQLSFEKNDVVELVKLNETAKQPAAEPQVDADGKPIEEKSVPWGPQRKKRRLHGYKEDPYVFFGENDPDYQAIKEFYQLDESLSQRCLLTRCVTEKKKNIYYCSEPIRDLVLNNENNIKIINTGVKTFVRCENRHTVHPFRLAQEGLQTSNAFMGASRRIQVEREDLVMMLNCTDPTQPPSTHELKKETQERCKELGVGSCILKYVDQRFTLYTVGWRGTSSLRAYVQKDETIHILRLLGADLSKFETNKYEDARVAAAAAADAEVGKSAEAEADSSGDGDATESTFSGSGAIDVTVAAETTGTPMDTEVVATS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
451	Phosphorylation	ELVKLNETAKQPAAE EEEECCCCCCCCCCC	37.77	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NSUN2_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NSUN2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NSUN2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NSUN2_DROME

Related Literatures of Post-Translational Modification