dbPTM

DBR1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DBR1_DROME
UniProt AC	Q9VSD7
Protein Name	Lariat debranching enzyme
Gene Name	ldbr
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	534
Subcellular Localization	Nucleus.
Protein Description	Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis (By similarity)..
Protein Sequence	MKIAVEGCAHGELERIYDTIEGIEKVGGTKIDLLLCCGDFQSTRNLEDLQTMAVPKKYLDMCSFYKYYSGELVAPVLTIFIGGNHEASNYLQELPYGGWVAPNIYYLGYAGVVNVNGVRIAGISGIFKGHDFLRGHHEFPPYTDSTCRSVYHVRQLEVFRLKQISGRVDIFLSHDWPTGIYEYGNKAQLLRKKPFFAADMESGKLGSQPLEELLKAVQPAYWFAAHLHCKFAALVPHNHSQKLGDAESSSSSSSSEDEDEEREKVKKAAPVPPPSKSVPVTKFLALDKCLPRRAFLQVVEVPSDPIEGTPRLEYDAEWLAILHSTNHLISVKENYYYLPGKKAGEFTERSNFTPTEEELEAVTAKFQKLQVPENFERTVPAFDPAEQSDYKHMFVDQPKVQLNPQSNTFCATLGIDDPLCLVLLANGLDLPAVGATECKDRETKSSKLQAVEEDVAEPLVTPTKRKLNLSLPAPTTAAADTTDENVIDLPEEEAEEAIIATETPHVEEPASVPASPNVKKLKRRNQNIYQAQED

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
461	Phosphorylation	DVAEPLVTPTKRKLN HHHCCCCCCCCCCCC	32.68	22668510
463	Phosphorylation	AEPLVTPTKRKLNLS HCCCCCCCCCCCCCC	33.83	28490779

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DBR1_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DBR1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DBR1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DBR1_DROME

Related Literatures of Post-Translational Modification