RS6_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RS6_DROME
• UniProt AC: P29327
• Protein Name: 40S ribosomal protein S6
• Gene Name: RpS6
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 248
• Protein Description: May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA..
• Protein Sequence: MKLNVSYPATGCQKLFEVVDEHKLRVFYEKRMGQVVEADILGDEWKGYQLRIAGGNDKQGFPMKQGVLTHGRVRLLLKKGHSCYRPRRTGERKRKSVRGCIVDANMSVLALVVLKKGEKDIPGLTDTTIPRRLGPKRASKIRKLYNLSKEDDVRRFVVRRPLPAKDNKKATSKAPKIQRLITPVVLQRKHRRIALKKKRQIASKEASADYAKLLVQRKKESKAKREEAKRRRSASIRESKSSVSSDKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
143	Acetylation	KRASKIRKLYNLSKE HHHHHHHHHHCCCCH	59.81	21791702
182	Phosphorylation	PKIQRLITPVVLQRK HHHHHHHHHHHHHHH	18.02	21082442
204	Acetylation	KKRQIASKEASADYA HHHHHHCHHHCHHHH	48.56	21791702
212	Acetylation	EASADYAKLLVQRKK HHCHHHHHHHHHHHH	35.80	21791702
233	Phosphorylation	EEAKRRRSASIRESK HHHHHHHHHHHHHHH	25.26	19429919
235	Phosphorylation	AKRRRSASIRESKSS HHHHHHHHHHHHHHH	24.35	19429919
239	Phosphorylation	RSASIRESKSSVSSD HHHHHHHHHHHCCCC	28.17	19429919
241	Phosphorylation	ASIRESKSSVSSDKK HHHHHHHHHCCCCCC	45.30	19429919
242	Phosphorylation	SIRESKSSVSSDKK- HHHHHHHHCCCCCC-	29.74	19429919
244	Phosphorylation	RESKSSVSSDKK--- HHHHHHCCCCCC---	34.46	19429919
245	Phosphorylation	ESKSSVSSDKK---- HHHHHCCCCCC----	51.82	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RS6_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RS6_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RS6_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CP9F2_DROME	Cyp9f2	physical	14605208
GNAS_DROME	Galphas	physical	14605208
NOL9_DROME	CG8414	physical	14605208
RL22_DROME	RpL22	physical	24129492
RL24_DROME	RpL24	physical	24129492

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233; SER-235; SER-239;SER-242; SER-244 AND SER-245, AND MASS SPECTROMETRY.
PubMed: 18327897